Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death (Q33948501)

30 July 2017

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title

Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death (English)

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30 July 2017

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Herceg Z

1

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PubMed ID

11376691

30 July 2017

Wang ZQ

series ordinal

2

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PubMed ID

11376691

30 July 2017

language of work or name

English

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publication date

1 June 2001

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30 July 2017

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30 July 2017

477

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30 July 2017

1-2

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30 July 2017

97-110

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Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks

30 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Analysis of poly(ADP-ribose) glycohydrolase activity in nuclear extracts from mammalian cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

ADP-ribosylation reactions

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Inhibitors of poly(adenosine diphosphate-ribose) synthesis: effect on other metabolic processes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Mutant cells defective in poly(ADP-ribose) synthesis due to stable alterations in enzyme activity or substrate availability

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

(ADP-ribose)n participates in DNA excision repair

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Role of poly(ADP-ribose) formation in DNA repair

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Deletion mutants of poly(ADP-ribose) polymerase support a model of cyclic association and dissociation of enzyme from DNA ends during DNA repair

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Expression of human poly(ADP-ribose) polymerase in Saccharomyces cerevisiae

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Overexpression of human poly(ADP-ribose) polymerase in transfected hamster cells leads to increased poly(ADP-ribosyl)ation and cellular sensitization to gamma irradiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Inhibition of cell proliferation in Saccharomyces cerevisiae by expression of human NAD+ ADP-ribosyltransferase requires the DNA binding domain ("zinc fingers")

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Functional expression of human poly(ADP-ribose) polymerase in Schizosaccharomyces pombe results in mitotic delay at G1, increased mutation rate, and sensitization to radiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Requirement for the Xrcc1 DNA base excision repair gene during early mouse development

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Inhibition of gene-specific repair of alkylation damage in cells depleted of poly(ADP-ribose) polymerase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Involvement of poly(ADP-ribose) polymerase in base excision repair

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Poly(ADP-ribose) catabolism in mammalian cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Histone shuttling by poly ADP-ribosylation

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

3-Aminobenzamide synergistically increases sister-chromatid exchanges in cells exposed to methyl methanesulfonate but not to ultraviolet light

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Stimulation of intrachromosomal homologous recombination in mammalian cells by an inhibitor of poly(ADP-ribosylation)

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Micronuclei and 3AB index in human and canine lymphocytes after in vitro X-irradiation

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

trans-dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against gamma-irradiation and N-methyl-N'-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyomavirus replicon

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

A dominant-negative mutant of human poly(ADP-ribose) polymerase affects cell recovery, apoptosis, and sister chromatid exchange following DNA damage

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Extrachromosomal recombination occurs efficiently in cells defective in various DNA repair systems

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

PARP is important for genomic stability but dispensable in apoptosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Chromosomal aberrations in PARP(-/-) mice: genome stabilization in immortalized cells by reintroduction of poly(ADP-ribose) polymerase cDNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

A p53-dependent mouse spindle checkpoint

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Abnormal centrosome amplification in the absence of p53.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Poly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Defective induction but normal activation and function of p53 in mouse cells lacking poly-ADP-ribose polymerase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Compensatory expression of p73 in PARP-deficient mouse fibroblasts as response to a reduced level of regularly spliced wild-type p53 protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Poly(ADP-ribose) polymerase inhibitors preserve oxidized nicotinamide adenine dinucleotide and adenosine 5'-triphosphate pools in DNA-damaged cells: mechanism of stimulation of unscheduled DNA synthesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Apoptosis induced by adenosine in human leukemia HL-60 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Possible involvement of poly(ADP-ribosyl) polymerase in triggering stress-induced apoptosis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Cell death protection by 3-aminobenzamide and other poly(ADP-ribose)polymerase inhibitors: different effects on human natural killer and lymphokine activated killer cell activities.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

3-Aminobenzamide protects cells from UV-B-induced apoptosis by acting on cytoskeleton and substrate adhesion.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Reactive oxygen intermediate(s) (ROI): common mediator(s) of poly(ADP-ribose)polymerase (PARP) cleavage and apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Complete inhibition of poly(ADP-ribose) polymerase activity prevents the recovery of C3H10T1/2 cells from oxidative stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Inhibition of apoptosis of a PARP(-)/(-)cell line transfected with PARP DNA-binding domain mutants.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Nitric oxide toxicity in islet cells involves poly(ADP-ribose) polymerase activation and concomitant NAD+ depletion.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

DNA repair: PARP - another guardian angel?

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Cellular responses to DNA damage in the absence of Poly(ADP-ribose) polymerase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis. Lesson from an uncleavable mutant

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Function of poly(ADP-ribose) polymerase in response to DNA damage: gene-disruption study in mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Protective effects of poly (ADP-ribose) synthase inhibitors in zymosan-activated plasma induced paw edema

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

The response of Parp knockout mice against DNA damaging agents.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Caspases: killer proteases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Granzyme B/Perforin-Mediated Apoptosis of Jurkat Cells Results in Cleavage of Poly(ADP-ribose) Polymerase to the 89-kDa Apoptotic Fragment and Less Abundant 64-kDa Fragment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Different cleavage pattern for poly(ADP-ribose) polymerase during necrosis and apoptosis in HL-60 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Intact cell evidence for the early synthesis, and subsequent late apopain-mediated suppression, of poly(ADP-ribose) during apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Transient poly(ADP-ribosyl)ation of nuclear proteins and role of poly(ADP-ribose) polymerase in the early stages of apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Apoptosis in the absence of poly-(ADP-ribose) polymerase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Cell death: the significance of apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Apoptosis: lessons from in vitro systems

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Failure of poly(ADP-ribose) polymerase cleavage by caspases leads to induction of necrosis and enhanced apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900111-7

10.1016/S0027-5107(01)00111-7

7 January 2021

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

11376691