Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity. (Q33949866)

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3 December 2019

title

Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity (English)

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3 December 2019

1

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3 December 2019

author name string

Kjalke M

series ordinal

2

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3 December 2019

Olsen OH

series ordinal

3

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3 December 2019

language of work or name

English

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publication date

6 November 2001

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Proceedings of the National Academy of Sciences of the United States of America

3 December 2019

published in

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3 December 2019

volume

98

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3 December 2019

issue

24

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3 December 2019

page(s)

13583-13588

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Substitution of valine for leucine 305 in factor VIIa increases the intrinsic enzymatic activity.

3 December 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61084

Binding of Zn2+ to a Ca2+ loop allosterically attenuates the activity of factor VIIa and reduces its affinity for tissue factor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61084

Peptide exosite inhibitors of factor VIIa as anticoagulants

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61084

Crystal structure of active site-inhibited human coagulation factor VIIa (des-Gla)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61084

Structure of human factor VIIa and its implications for the triggering of blood coagulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61084

Regulation of the catalytic function of coagulation factor VIIa by a conformational linkage of surface residue Glu 154 to the active site

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61084

Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61084

Platelet activity of high-dose factor VIIa is independent of tissue factor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61084

Incorporation of an active site inhibitor in factor VIIa alters the affinity for tissue factor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61084

Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61084

Structural changes in factor VIIa induced by Ca2+ and tissue factor studied using circular dichroism spectroscopy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61084

Site-directed mutagenesis but not gamma-carboxylation of Glu-35 in factor VIIa affects the association with tissue factor.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61084

The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61084

Roles of the membrane-interactive regions of factor VIIa and tissue factor. The factor VIIa Gla domain is dispensable for binding to tissue factor but important for activation of factor X.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61084

Amino acid sequence and posttranslational modifications of human factor VIIa from plasma and transfected baby hamster kidney cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61084

Recombinant human extrinsic pathway inhibitor. Production, isolation, and characterization of its inhibitory activity on tissue factor-initiated coagulation reactions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61084

The coagulation cascade: initiation, maintenance, and regulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61084

Residue Met(156) contributes to the labile enzyme conformation of coagulation factor VIIa

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.241339498

Factor VIIa modified in the 170 loop shows enhanced catalytic activity but does not change the zymogen-like property

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.241339498

Substitution of aspartic acid for methionine-306 in factor VIIa abolishes the allosteric linkage between the active site and the binding interface with tissue factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.241339498

Molecular mechanism of tissue factor-mediated acceleration of factor VIIa activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.241339498

Activation and active site occupation alter conformation in the region of the first epidermal growth factor-like domain of human factor VII

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.241339498

Platelet procoagulant complex assembly in a tissue factor-initiated system

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.241339498

Ca2+ binding to the first epidermal growth factor-like domain of factor VIIa increases amidolytic activity and tissue factor affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.241339498

Chemical cross-linking of activated coagulation factor VII with soluble tissue factor: calcium ions are not essential for full amidolytic activity of the factor VIIa-tissue factor complex after complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.241339498

Thermal effects on an enzymatically latent conformation of coagulation factor VIIa

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.241339498

Identification of regions of bovine factor VII essential for binding to tissue factor

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11698657

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Influence of the gamma-carboxyglutamic acid-rich domain and hydrophobic stack of factor VIIa on tissue factor binding

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11698657

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The effect of active site-inhibited factor VIIa on tissue factor-initiated coagulation using platelets before and after aspirin administration

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11698657

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.241339498

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11698657%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11698657%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

1 reference