Forced evolution of glutathione S-transferase to create a more efficient drug detoxication enzyme. (Q33950629)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7667259%20AND%20SRC:MED&resulttype=core&format=json

23 October 2019

title

Forced evolution of glutathione S-transferase to create a more efficient drug detoxication enzyme (English)

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23 October 2019

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1

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23 October 2019

author name string

W E Fahl

series ordinal

2

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23 October 2019

language of work or name

English

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publication date

1 August 1995

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7667259%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

23 October 2019

published in

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23 October 2019

volume

92

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23 October 2019

issue

18

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23 October 2019

page(s)

8140-8144

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Tyrosine 115 participates both in chemical and physical steps of the catalytic mechanism of a glutathione S-transferase.

23 October 2019

cites work

1 reference

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5 July 2018

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Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes

5 July 2018

1 reference

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Snapshots along the reaction coordinate of an SNAr reaction catalyzed by glutathione transferase

5 July 2018

1 reference

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Structure and function of the xenobiotic substrate binding site of a glutathione S-transferase as revealed by X-ray crystallographic analysis of product complexes with the diastereomers of 9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene

5 July 2018

1 reference

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Studies on the metabolism of benzo[a]pyrene and dose-dependent differences in the mutagenic profile of its ultimate carcinogenic metabolite

5 July 2018

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Glutathione-associated enzymes in anticancer drug resistance.

5 July 2018

1 reference

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Mammalian glutathione S-transferase: regulation of an enzyme system to achieve chemotherapeutic efficacy.

5 July 2018

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High-dose cisplatin therapy in ovarian cancer.

5 July 2018

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Glutathione S-transferases in nitrogen mustard-resistant and -sensitive cell lines.

5 July 2018

1 reference

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Cellular heterogeneity and drug resistance in two ovarian adenocarcinoma cell lines derived from a single patient.

5 July 2018

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Amplification and increased expression of alpha class glutathione S-transferase-encoding genes associated with resistance to nitrogen mustards

5 July 2018

1 reference

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Glutathione transferases--structure and catalytic activity

5 July 2018

1 reference

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A reliable method for random mutagenesis: the generation of mutant libraries using spiked oligodeoxyribonucleotide primers

5 July 2018

1 reference

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The spontaneous and glutathione S-transferase-mediated reaction of chlorambucil with glutathione

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41111

Expression of recombinant glutathione S-transferase pi, Ya, or Yb1 confers resistance to alkylating agents

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41111

NMR studies of the conjugation of mechlorethamine with glutathione.

5 July 2018

1 reference

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The enzymes of detoxication

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41111

Expression in Escherichia coli of rat liver cytosolic glutathione S-transferase Yc cDNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41111

The three-dimensional structure of class pi glutathione S-transferase in complex with glutathione sulfonate at 2.3 A resolution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41111

Theta, a new class of glutathione transferases purified from rat and man

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41111

Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41111

The three-dimensional structure of a glutathione S-transferase from the mu gene class. Structural analysis of the binary complex of isoenzyme 3-3 and glutathione at 2.2-A resolution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41111

Site-directed mutagenesis of glutathione S-transferase YaYa. Important roles of tyrosine 9 and aspartic acid 101 in catalysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41111

Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41111

Glutathione peroxidase activity in selenium-deficient rat liver

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41111

Kinetic analysis of the reaction of melphalan with water, phosphate, and glutathione.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41111

Glutathione and glutathione-dependent enzymes in ovarian adenocarcinoma cell lines derived from a patient before and after the onset of drug resistance: intrinsic differences and cell cycle effects.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41111

Structural studies on human glutathione S-transferase pi. Substitution mutations to determine amino acids necessary for binding glutathione

29 October 2018

1 reference

12 December 2020

Mutational substitution of residues implicated by crystal structure in binding the substrate glutathione to human glutathione S-transferase pi

1 reference

12 December 2020

Three-dimensional structure of class π glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8 Å resolution

1 reference

12 December 2020

Selective modification of glutathione metabolism

1 reference

12 December 2020

Characterization of melphalan-glutathione adducts whose formation is catalyzed by glutathione transferases

1 reference

12 December 2020

Structural studies on human glutathione S-transferase pi. Family of native-specific monoclonal antibodies used to block catalysis

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.92.18.8140

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7667259%20AND%20SRC:MED&resulttype=core&format=json

23 October 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7667259%20AND%20SRC:MED&resulttype=core&format=json

23 October 2019

1 reference