Chemical proteomics-based analysis of off-target binding profiles for rosiglitazone and pioglitazone: clues for assessing potential for cardiotoxicity. (Q33961458)

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English	Chemical proteomics-based analysis of off-target binding profiles for rosiglitazone and pioglitazone: clues for assessing potential for cardiotoxicity.	scientific article

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scholarly article

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13 February 2020

Chemical proteomics-based analysis of off-target binding profiles for rosiglitazone and pioglitazone: clues for assessing potential for cardiotoxicity (English)

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13 February 2020

(RS)-rosiglitazone

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Mohamed F El-Mansy

2

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13 February 2020

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Brian R Hoffmann

1

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13 February 2020

Daniel S Sem

3

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13 February 2020

Andrew S Greene

4

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publication date

28 September 2012

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13 February 2020

Journal of Medicinal Chemistry

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13 February 2020

55

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13 February 2020

19

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13 February 2020

8260-8271

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13 February 2020

Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery

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5 July 2018

Cardiac ion channel modulation by the hypoglycaemic agent rosiglitazone

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5 July 2018

Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies

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5 July 2018

Visualize: a free and open source multifunction tool for proteomics data analysis

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5 July 2018

Thiazolidinediones and risk of heart failure in patients with or at high risk of type 2 diabetes mellitus: a meta-analysis and meta-regression analysis of placebo-controlled randomized clinical trials.

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5 July 2018

Effects of rosiglitazone on the configuration of action potentials and ion currents in canine ventricular cells

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5 July 2018

Rosiglitazone inhibits Kv4.3 potassium channels by open-channel block and acceleration of closed-state inactivation

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5 July 2018

Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

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5 July 2018

Thiazolidinediones up-regulate insulin-like growth factor-1 receptor via a peroxisome proliferator-activated receptor gamma-independent pathway

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5 July 2018

Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazone

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5 July 2018

7-Chloroarctinone-b as a new selective PPARgamma antagonist potently blocks adipocyte differentiation

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5 July 2018

Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA

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5 July 2018

Thiazolidinedione drugs block cardiac KATP channels and may increase propensity for ischaemic ventricular fibrillation in pigs

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5 July 2018

SIK2 can be activated by deprivation of nutrition and it inhibits expression of lipogenic genes in adipocytes

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5 July 2018

Suppression of 11beta-hydroxysteroid dehydrogenase type 1 with RNA interference substantially attenuates 3T3-L1 adipogenesis

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5 July 2018

Uncertain effects of rosiglitazone on the risk for myocardial infarction and cardiovascular death

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5 July 2018

Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

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5 July 2018

Glitazones induce astroglioma cell death by releasing reactive oxygen species from mitochondria: modulation of cytotoxicity by nitric oxide

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5 July 2018

Deficiency of mitochondrial ATP synthase of nuclear genetic origin

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5 July 2018

Receptor-independent actions of PPAR thiazolidinedione agonists: is mitochondrial function the key?

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5 July 2018

Inhibition of cell proliferation by potential peroxisome proliferator-activated receptor (PPAR) gamma agonists and antagonists.

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5 July 2018

Mitochondrial respiratory chain dysfunction, a non-receptor-mediated effect of synthetic PPAR-ligands: biochemical and pharmacological implications

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5 July 2018

Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association

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5 July 2018

Mechanisms of troglitazone hepatotoxicity

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5 July 2018

Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2

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5 July 2018

Troglitazone and pioglitazone attenuate agonist-dependent Ca2+ mobilization and cell proliferation in vascular smooth muscle cells

1 reference

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5 July 2018

Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma

1 reference

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5 July 2018

15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma

1 reference

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5 July 2018

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

1 reference

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5 July 2018

Risk of cardiovascular events and all-cause mortality in patients treated with thiazolidinediones in a managed-care population

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29 October 2018

Opposite effects of pioglitazone and rosiglitazone on mitochondrial respiration in skeletal muscle of patients with type 2 diabetes.

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29 October 2018

Commentary on 'Case series of liver failure associated with rosiglitazone and pioglitazone' by James Floyd et al.

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29 October 2018

Commentary on 'Case series of liver failure associated with rosiglitazone and pioglitazone' by Floyd et al.

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29 October 2018

Activation of PPARgamma by rosiglitazone attenuates intestinal Cl- secretion.

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29 October 2018

Cl- -channel is essential for LDL-induced cell proliferation via the activation of Erk1/2 and PI3k/Akt and the upregulation of Egr-1 in human aortic smooth muscle cells.

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29 October 2018

Chemical proteomics-based drug design: target and antitarget fishing with a catechol-rhodanine privileged scaffold for NAD(P)(H) binding proteins

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29 October 2018

Rosiglitazone and cardiovascular risk.

1 reference

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29 October 2018

Acute pulmonary edema due to rosiglitazone use in a patient with diabetes mellitus.

1 reference

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29 October 2018

Novel PPARgamma agonists GI 262570, GW 7845, GW 1929, and pioglitazone decrease calcium channel function and myogenic tone in rat mesenteric arteries

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29 October 2018

Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?

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29 October 2018

Rosiglitazone Activates Renal Sodium- and Water-Reabsorptive Pathways and Lowers Blood Pressure in Normal Rats

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29 October 2018

Peroxisome proliferator-activated receptor gamma thiazolidinedione agonists increase glucose metabolism in astrocytes

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29 October 2018

Comparative actions of insulin sensitizers on ion channels in vascular smooth muscle

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29 October 2018

Regulation of mitochondrial ATP synthase activity in human myocardium.

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29 October 2018

Effects of pioglitazone on calcium channels in vascular smooth muscle.

1 reference

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29 October 2018

Differential effects of insulin-sensitizers troglitazone and rosiglitazone on ion currents in rat vascular myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22970990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paradoxically decreased HDL-cholesterol levels associated with rosiglitazone therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22970990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RETRACTED: Rosiglitazone and pioglitazone aggravate doxorubicin-induced cardiomyopathy in Wistar rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22970990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Troglitazone inhibits voltage-dependent calcium currents in guinea pig cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22970990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thiazolidinediones and the risk of edema: a meta-analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22970990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM301204R

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13 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22970990%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22970990%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

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