Role for homodimerization in growth deregulation by E2a fusion proteins (Q33964971)

30 July 2017

title

Role for homodimerization in growth deregulation by E2a fusion proteins (English)

1 reference

30 July 2017

R Bayly

1

1 reference

30 July 2017

D P LeBrun

series ordinal

2

1 reference

30 July 2017

language of work or name

English

0 references

publication date

1 August 2000

1 reference

Molecular and Cellular Biology

30 July 2017

published in

1 reference

30 July 2017

volume

20

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30 July 2017

issue

16

1 reference

30 July 2017

page(s)

5789-5796

1 reference

CREB-binding protein and p300: molecular integrators of hematopoietic transcription.

30 July 2017

cites work

1 reference

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5 July 2018

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A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex

5 July 2018

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Disrupted differentiation and oncogenic transformation of lymphoid progenitors in E2A-HLF transgenic mice

5 July 2018

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Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia

5 July 2018

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Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation

5 July 2018

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Identification of a novel molecular partner of the E2A gene in childhood leukemia

5 July 2018

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Two candidate downstream target genes for E2A-HLF

5 July 2018

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The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF

5 July 2018

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Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity

5 July 2018

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p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene

5 July 2018

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Notch inhibition of E47 supports the existence of a novel signaling pathway

5 July 2018

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The Tal1 oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains

5 July 2018

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Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins

5 July 2018

1 reference

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E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas

5 July 2018

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Cell transformation mediated by homodimeric E2A-HLF transcription factors

5 July 2018

1 reference

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The Hox cooperativity motif of the chimeric oncoprotein E2a-Pbx1 is necessary and sufficient for oncogenesis

5 July 2018

1 reference

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Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation

5 July 2018

1 reference

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The TAL1/Scl basic helix-loop-helix protein blocks myogenic differentiation and E-box dependent transactivation

5 July 2018

1 reference

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Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

Intradimerically tethered DNA topoisomerase II is catalytically active in DNA transport

5 July 2018

1 reference

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DNA-binding by oncoprotein E2a-Pbx1 is important for blocking differentiation but dispensable for fibroblast transformation.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

The AD1 transactivation domain of E2A contains a highly conserved helix which is required for its activity in both Saccharomyces cerevisiae and mammalian cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

Thermodynamic characterization of the structural stability of the coiled-coil region of the bZIP transcription factor GCN4.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

An immediate early human gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

Dimerization of leucine zippers analyzed by random selection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

The E2A gene product contains two separable and functionally distinct transcription activation domains

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

Id proteins control growth induction in mammalian cells

5 July 2018

1 reference

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E2A-Pbx1, the t(1;19) translocation protein of human pre-B-cell acute lymphocytic leukemia, causes acute myeloid leukemia in mice

5 July 2018

1 reference

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Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

Regulation of G1 progression by E2A and Id helix-loop-helix proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

Inhibition of cellular differentiation by the SCL/tal oncoprotein: transcriptional repression by an Id-like mechanism.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

Uses for GAL4 expression in mammalian cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

E2A-HLF-mediated cell transformation requires both the trans-activation domains of E2A and the leucine zipper dimerization domain of HLF.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

HLH forced dimers: tethering MyoD to E47 generates a dominant positive myogenic factor insulated from negative regulation by Id.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

B cell differentiation: role of E2A and Pax5/BSAP transcription factors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

Oncogene jun encodes a sequence-specific trans-activator similar to AP-1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

The JUN oncoprotein, a vertebrate transcription factor, activates transcription in yeast.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

Separation of DNA binding from the transcription-activating function of a eukaryotic regulatory protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

The DNA-binding domains of the jun oncoprotein and the yeast GCN4 transcriptional activator protein are functionally homologous

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

DNA binding specificity of homeodomains

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

DNA recognition by GAL4: structure of a protein-DNA complex.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

Chimeric c-Jun containing an heterologous homodimerization domain transforms primary chick embryo fibroblasts.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

An amino-terminal fragment of GAL4 binds DNA as a dimer

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86056

The gene for enhancer binding proteins E12/E47 lies at the t(1;19) breakpoint in acute leukemias

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10913162

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Yeast GCN4 as a probe for oncogenesis by AP-1 transcription factors: transcriptional activation through AP-1 sites is not sufficient for cellular transformation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10913162

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.20.16.5789-5796.2000

1 reference

30 July 2017

1 reference

30 July 2017

1 reference