Reduction of target gene expression by a modified U1 snRNA. (Q33967927)

30 July 2017

title

Reduction of target gene expression by a modified U1 snRNA. (English)

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30 July 2017

S A Beckley

1

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30 July 2017

P Liu

2

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30 July 2017

M L Stover

3

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30 July 2017

S I Gunderson

4

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30 July 2017

A C Lichtler

5

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30 July 2017

D W Rowe

6

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30 July 2017

language of work or name

English

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publication date

1 April 2001

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Molecular and Cellular Biology

30 July 2017

published in

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30 July 2017

volume

21

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30 July 2017

issue

8

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30 July 2017

page(s)

2815-2825

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Tracking COL1A1 RNA in osteogenesis imperfecta. splice-defective transcripts initiate transport from the gene but are retained within the SC35 domain

30 July 2017

cites work

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Two problems in antisense biotechnology: in vitro delivery and the design of antisense experiments

5 July 2018

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Fourteen residues of the U1 snRNP-specific U1A protein are required for homodimerization, cooperative RNA binding, and inhibition of polyadenylation.

5 July 2018

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A nuclear 3'-5' exonuclease involved in mRNA degradation interacts with Poly(A) polymerase and the hnRNA protein Npl3p

5 July 2018

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Double-target antisense U7 snRNAs promote efficient skipping of an aberrant exon in three human beta-thalassemic mutations

5 July 2018

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mRNA localization signals can enhance the intracellular effectiveness of hammerhead ribozymes

5 July 2018

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Analysis of mammalian cis-regulatory DNA elements by homologous recombination

5 July 2018

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Utilization of splicing elements and polyadenylation signal elements in the coupling of polyadenylation and last-intron removal

5 July 2018

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Ten years of gene targeting: targeted mouse mutants, from vector design to phenotype analysis

5 July 2018

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Gene repair using chimeric RNA/DNA oligonucleotides

5 July 2018

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Design, characterization and testing of tRNA3Lys-based hammerhead ribozymes

5 July 2018

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Processing of endogenous pre-mRNAs in association with SC-35 domains is gene specific

5 July 2018

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Factors governing the activity in vivo of ribozymes transcribed by RNA polymerase III.

5 July 2018

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Antisense RNA: function and fate of duplex RNA in cells of higher eukaryotes.

5 July 2018

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U1 snRNP inhibits pre-mRNA polyadenylation through a direct interaction between U1 70K and poly(A) polymerase

5 July 2018

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Extending the cleavage rules for the hammerhead ribozyme: mutating adenosine15.1 to inosine15.1 changes the cleavage site specificity from N16.2U16.1H17 to N16.2C16.1H17.

5 July 2018

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Inhibition of human immunodeficiency virus type 1 replication by nuclear chimeric anti-HIV ribozymes in a human T lymphoblastoid cell line

5 July 2018

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Identification of a novel, non-snRNP protein complex containing U1A protein.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Inhibition of fibrillin 1 expression using U1 snRNA as a vehicle for the presentation of antisense targeting sequence

5 July 2018

1 reference

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In vivo selection of RNAs that localize in the nucleus

5 July 2018

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The expression cassette determines the functional activity of ribozymes in mammalian cells by controlling their intracellular localization.

5 July 2018

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A suboptimal 5' splice site is a cis-acting determinant of nuclear export of polyomavirus late mRNAs

5 July 2018

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Involvement of U1 small nuclear ribonucleoproteins (snRNP) in 5' splice site-U1 snRNP interaction

5 July 2018

1 reference

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U1 small nuclear RNA chimeric ribozymes with substrate specificity for the Rev pre-mRNA of human immunodeficiency virus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Role of polyadenylation in nucleocytoplasmic transport of mRNA

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Nuclear retention of COL1A1 messenger RNA identifies null alleles causing mild osteogenesis imperfecta

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Nucleoplasmic organization of small nuclear ribonucleoproteins in cultured human cells.

5 July 2018

1 reference

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The human U1 snRNP-specific U1A protein inhibits polyadenylation of its own pre-mRNA.

5 July 2018

1 reference

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A three-dimensional view of precursor messenger RNA metabolism within the mammalian nucleus

5 July 2018

1 reference

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Defective splicing of mRNA from one COL1A1 allele of type I collagen in nondeforming (type I) osteogenesis imperfecta

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Disruption of base pairing between the 5' splice site and the 5' end of U1 snRNA is required for spliceosome assembly

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Importance of exocyclic base functional groups of central core guanosines for hammerhead ribozyme activity

5 July 2018

1 reference

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Mechanisms for selecting 5' splice sites in mammalian pre-mRNA splicing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Specific inhibition of expression of a human collagen gene (COL1A1) with modified antisense oligonucleotides. The most effective target sites are clustered in double-stranded regions of the predicted secondary structure for the mRNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Sequences homologous to 5' splice sites are required for the inhibitory activity of papillomavirus late 3' untranslated regions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Association of nuclear matrix antigens with exon-containing splicing complexes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Exon recognition in vertebrate splicing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

The human immunodeficiency virus type 1 Rev protein and the Rev-responsive element counteract the effect of an inhibitory 5' splice site in a 3' untranslated region

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Single base discrimination for ribonuclease H-dependent antisense effects within intact human leukaemia cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

U1 Small Nuclear RNAs with Altered Specificity Can Be Stably Expressed in Mammalian Cells and Promote Permanent Changes in Pre-mRNA Splicing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Transcription of a gene for human U1 small nuclear RNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Heterogeneity of human U1 snRNAs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

An E. coli beta-galactosidase cassette suitable for study of eukaryotic expression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Bacterial beta-galactosidase as a marker of Rous sarcoma virus gene expression and replication

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Differential effects of polyadenylation regions on gene expression in mammalian cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Poly(A), poly(A) binding protein and the regulation of mRNA stability

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Regulation by HIV Rev depends upon recognition of splice sites

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Multiple domains of U1 snRNA, including U1 specific protein binding sites, are required for splicing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Exon definition may facilitate splice site selection in RNAs with multiple exons

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Efficient site-directed mutagenesis using uracil-containing DNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Who's on first? The U1 snRNP-5' splice site interaction and splicing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

U1 and U2 small nuclear RNAs are present in nuclear speckles

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Control of the functional activity of an antisense RNA by a tetracycline-responsive derivative of the human U6 snRNA promoter

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Retrovirally expressed anti-HIV ribozymes confer a selective survival advantage on CD4+ T cells in vitro

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Stem-loop 1 of the U1 snRNP plays a critical role in the suppression of HIV-1 polyadenylation.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Suppression of the 5' splice site mutation in the Nagase analbuminemic rat with mutated U1snRNA.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

The HIV-1 5' LTR poly(A) site is inactivated by U1 snRNP interaction with the downstream major splice donor site.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Gene therapy for human immunodeficiency virus infection: genetic antiviral strategies and targets for intervention

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

True genes for human U1 small nuclear RNA. Copy number, polymorphism, and methylation.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86911

Designing ribozymes for the inhibition of gene expression

29 October 2018

1 reference

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In vitro selection of an allosteric ribozyme that transduces analytes to amplicons

1 reference

12 December 2020

Synergistic stimulation of HIV-1 rev-dependent export of unspliced mRNA to the cytoplasm by hnRNP A1

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12 December 2020

An improved fluor diffusion assay for chloramphenicol acetyltransferase gene expression

1 reference

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The human U1A snRNP protein regulates polyadenylation via a direct interaction with poly(A) polymerase

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Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide

1 reference

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Involvement of the carboxyl terminus of vertebrate poly(A) polymerase in U1A autoregulation and in the coupling of splicing and polyadenylation

1 reference

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Formation of a catalytically active dimer by tRNA(Val)-driven short ribozymes

1 reference

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Performance and limits of the mixed-phase assay for chloramphenicol acetyltransferase at low [3H]acetyl-CoA concentration

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Direct interaction of the U1 snRNP-A protein with the upstream efficiency element of the SV40 late polyadenylation signal

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Poly(A) site selection in the HIV-1 provirus: inhibition of promoter-proximal polyadenylation by the downstream major splice donor site

1 reference

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Interaction between the U1 snRNP-A protein and the 160-kD subunit of cleavage-polyadenylation specificity factor increases polyadenylation efficiency in vitro

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The U1 small nuclear RNA-protein complex selectively binds a 5' splice site in vitro

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Analysis of cytoplasmic and nuclear messenger RNA in fibroblasts from patients with type I osteogenesis imperfecta

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12 December 2020

Hierarchy for 5′ splice site preference determined in vivo

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Simple, inexpensive preparation of T1/T2 ribonuclease suitable for use in RNase protection experiments

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The effects of 5'-capping, 3'-polyadenylation and leader composition upon the translation and stability of mRNA in a cell-free extract derived from the yeast Saccharomyces cerevisiae

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10.1128/MCB.21.8.2815-2825.2001

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DOI

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30 July 2017

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30 July 2017

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