Approaches to discovery and characterization of inhibitors of amyloid beta-peptide polymerization (Q33971304)

30 July 2017

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title

Approaches to discovery and characterization of inhibitors of amyloid beta-peptide polymerization (English)

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30 July 2017

M A Findeis

1

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PubMed ID

10899433

30 July 2017

language of work or name

English

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publication date

1 July 2000

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30 July 2017

9

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Biochimica et Biophysica Acta

inferred from page(s)

published in

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30 July 2017

1502

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30 July 2017

1

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30 July 2017

76-84

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Alzheimer's disease: genotypes, phenotypes, and treatments

30 July 2017

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7 January 2021

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7 January 2021

Missense on the membrane

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7 January 2021

Amyloid, the presenilins and Alzheimer's disease

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7 January 2021

Amyloid beta-peptide is produced by cultured cells during normal metabolism

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7 January 2021

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

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7 January 2021

A role for the beta-amyloid precursor protein in memory?

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7 January 2021

Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice.

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7 January 2021

In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity

1 reference

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7 January 2021

Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid-mediated cell death

1 reference

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7 January 2021

Amyloid beta protein-induced neuronal cell death: neurotoxic properties of aggregated amyloid beta protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900034-X

7 January 2021

Alzheimer's disease. Amyloid ox-tox transducers.

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7 January 2021

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

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7 January 2021

Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils

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7 January 2021

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

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7 January 2021

Neuron loss in APP transgenic mice

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7 January 2021

Therapeutic approaches related to amyloid-beta peptide and Alzheimer's disease

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7 January 2021

Inhibition of amyloid formation: a strategy to delay the onset of Alzheimer's disease.

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7 January 2021

Cognitive enhancement therapy for Alzheimer's disease. The way forward

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7 January 2021

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

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7 January 2021

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

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7 January 2021

Design and testing of inhibitors of fibril formation

1 reference

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7 January 2021

Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution

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7 January 2021

Thioflavine T interaction with amyloid β-sheet structures

1 reference

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7 January 2021

Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavin T1.

1 reference

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7 January 2021

In vitro growth of Alzheimer's disease beta-amyloid plaques displays first-order kinetics.

1 reference

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7 January 2021

Arrest of beta-amyloid fibril formation by a pentapeptide ligand

1 reference

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7 January 2021

On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants

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7 January 2021

Recognition sequence design for peptidyl modulators of beta-amyloid aggregation and toxicity.

1 reference

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7 January 2021

Structure of beta-crystallite assemblies formed by Alzheimer beta-amyloid protein analogues: analysis by x-ray diffraction.

1 reference

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7 January 2021

Conformation and fibrillogenesis of Alzheimer A beta peptides with selected substitution of charged residues.

1 reference

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7 January 2021

Observation of metastable Abeta amyloid protofibrils by atomic force microscopy

1 reference

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7 January 2021

Atomic force microscopic imaging of seeded fibril formation and fibril branching by the Alzheimer's disease amyloid-beta protein.

1 reference

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7 January 2021

In situ atomic force microscopy study of Alzheimer's beta-amyloid peptide on different substrates: new insights into mechanism of beta-sheet formation

1 reference

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7 January 2021

Watching amyloid fibrils grow by time-lapse atomic force microscopy

1 reference

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7 January 2021

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1 reference

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7 January 2021

Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red.

1 reference

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7 January 2021

Development of small molecule probes for the Beta-amyloid protein of Alzheimer's Disease

1 reference

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7 January 2021

Chrysamine-G, a lipophilic analogue of Congo red, inhibits A beta-induced toxicity in PC12 cells

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7 January 2021

Neurofibrillary tangles and senile plaques in brain of elderly leprosy patients

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7 January 2021

Existence of senile plaques in the brains of elderly leprosy patients

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7 January 2021

Rifampicin prevents the aggregation and neurotoxicity of amyloid beta protein in vitro.

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7 January 2021

Inhibition of amyloid beta protein aggregation and neurotoxicity by rifampicin. Its possible function as a hydroxyl radical scavenger.

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7 January 2021

Interaction of the anthracycline 4'-iodo-4'-deoxydoxorubicin with amyloid fibrils: inhibition of amyloidogenesis

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7 January 2021

Effectiveness of anthracycline against experimental prion disease in Syrian hamsters.

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7 January 2021

Inhibition of fibril formation in beta-amyloid peptide by a novel series of benzofurans

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7 January 2021

Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides

1 reference

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7 January 2021

Modified-peptide inhibitors of amyloid beta-peptide polymerization.

1 reference

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7 January 2021

Inhibition of Alzheimer's amyloidosis by peptides that prevent beta-sheet conformation

1 reference

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7 January 2021

Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy.

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7 January 2021

A strategy for designing inhibitors of beta-amyloid toxicity

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7 January 2021

Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease

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7 January 2021

Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease

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7 January 2021

Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E.

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7 January 2021

Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease

1 reference

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7 January 2021

Seeding of A beta fibril formation is inhibited by all three isotypes of apolipoprotein E.

1 reference

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7 January 2021

An ApoE-Abeta inhibition complex in Abeta fibril extension

1 reference

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7 January 2021

Disaggregation of Alzheimer beta-amyloid by site-directed mAb.

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7 January 2021

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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7 January 2021

beta-Cyclodextrin interacts with the Alzheimer amyloid beta-A4 peptide

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7 January 2021

Nicotine inhibits amyloid formation by the beta-peptide.

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7 January 2021

Inhibition of Alzheimer beta-fibrillogenesis by melatonin

1 reference

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7 January 2021

Inhibiting transthyretin conformational changes that lead to amyloid fibril formation

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7 January 2021

Cellular mechanisms of beta-amyloid production and secretion

1 reference

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7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

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7 January 2021

Endogenous proteins controlling amyloid beta-peptide polymerization. Possible implications for beta-amyloid formation in the central nervous system and in peripheral tissues

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7 January 2021

Aggregation and disaggregation of senile plaques in Alzheimer disease

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7 January 2021

Familial amyloid polyneuropathy

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7 January 2021

Resolution of heart failure in patients with AL amyloidosis

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7 January 2021

10.1016/S0925-4439(00)00034-X

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

10899433