The estrogen-related receptor α inverse agonist XCT 790 is a nanomolar mitochondrial uncoupler (Q33975144)

30 July 2017

title

The estrogen-related receptor α inverse agonist XCT 790 is a nanomolar mitochondrial uncoupler (English)

1 reference

30 July 2017

Banu Eskiocak

1

1 reference

30 July 2017

Aktar Ali

series ordinal

2

1 reference

30 July 2017

Michael A White

series ordinal

3

1 reference

30 July 2017

language of work or name

English

0 references

publication date

14 July 2014

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30 July 2017

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30 July 2017

volume

53

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30 July 2017

issue

29

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30 July 2017

page(s)

4839-4846

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Development of a stable cell line with an intact PGC-1α/ERRα axis for screening environmental chemicals.

30 July 2017

cites work

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The biarylpyrazole compound AM251 alters mitochondrial physiology via proteolytic degradation of ERRα

5 July 2018

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The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer

5 July 2018

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Protein kinase C epsilon affects mitochondrial function through estrogen-related receptor alpha

5 July 2018

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5 July 2018

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Functional parsing of driver mutations in the colorectal cancer genome reveals numerous suppressors of anchorage-independent growth

5 July 2018

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Kinase suppressor of ras 1 (KSR1) regulates PGC1α and estrogen-related receptor α to promote oncogenic Ras-dependent anchorage-independent growth

5 July 2018

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The cannabinoid receptor inverse agonist AM251 regulates the expression of the EGF receptor and its ligands via destabilization of oestrogen-related receptor α protein

5 July 2018

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Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

5 July 2018

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PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types

5 July 2018

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WNT11 Expression Is Induced by Estrogen-Related Receptor α and β-Catenin and Acts in an Autocrine Manner to Increase Cancer Cell Migration

5 July 2018

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A Role for the orphan nuclear receptor estrogen-related receptor alpha in endometrial stromal cell decidualization and expression of genes implicated in energy metabolism.

5 July 2018

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5 July 2018

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PGC-1alpha coactivates estrogen-related receptor-alpha to induce the expression of glucokinase

5 July 2018

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5 July 2018

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The art of the chemical probe

5 July 2018

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Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation

5 July 2018

1 reference

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Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro

5 July 2018

1 reference

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Peroxisome proliferator-activated receptor gamma coactivator-1alpha enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase

5 July 2018

1 reference

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5 July 2018

1 reference

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Modulating estrogen receptor-related receptor-alpha activity inhibits cell proliferation

5 July 2018

1 reference

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A crowdsourcing evaluation of the NIH chemical probes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116149

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116149

The orphan receptor ERRalpha interferes with steroid signaling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116149

AMPK phosphorylation of raptor mediates a metabolic checkpoint

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116149

Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-alpha degradation by the estrogen receptor-related receptor-alpha inverse agonist XCT790.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116149

Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins

5 July 2018

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Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor alpha

5 July 2018

1 reference

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Regulation of PPARgamma coactivator 1alpha (PGC-1alpha) signaling by an estrogen-related receptor alpha (ERRalpha) ligand

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116149

Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle

5 July 2018

1 reference

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PPARgamma coactivator 1beta/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116149

The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha).

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116149

Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116149

The molecular mechanism of action of the proton ionophore FCCP (carbonylcyanide p-trifluoromethoxyphenylhydrazone).

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116149

PGC-1β regulates mouse carnitine-acylcarnitine translocase through estrogen-related receptor α.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116149

The nuclear receptor ERRalpha is required for the bioenergetic and functional adaptation to cardiac pressure overload.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116149

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116149

A polymorphic autoregulatory hormone response element in the human estrogen-related receptor alpha (ERRalpha) promoter dictates peroxisome proliferator-activated receptor gamma coactivator-1alpha control of ERRalpha expression.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116149

Estrogen receptor-related receptor α regulation by interleukin-1β in prostaglandin E(2)- and cAMP-dependent pathways in osteoarthritic chondrocytes

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24999922

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Location and function of three sites phosphorylated on rat acetyl-CoA carboxylase by the AMP-activated protein kinase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24999922

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The kinetic mechanism by which CCCP (carbonyl cyanidem-Chlorophenylhydrazone) transports protons across membranes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24999922

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/BI500737N

1 reference

30 July 2017

1 reference

30 July 2017

1 reference