The immune response modifier imiquimod requires STAT-1 for induction of interferon, interferon-stimulated genes, and interleukin-6. (Q33976658)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10103191%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

title

The immune response modifier imiquimod requires STAT-1 for induction of interferon, interferon-stimulated genes, and interleukin-6 (English)

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12 November 2019

author name string

R L Bottrel

1

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12 November 2019

Y L Yang

2

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12 November 2019

D E Levy

3

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12 November 2019

M Tomai

4

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12 November 2019

L F Reis

5

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12 November 2019

language of work or name

English

0 references

publication date

1 April 1999

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Antimicrobial Agents and Chemotherapy

12 November 2019

published in

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12 November 2019

volume

43

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12 November 2019

issue

4

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12 November 2019

page(s)

856-861

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Mice lacking the gamma interferon receptor have an impaired granulomatous reaction to Schistosoma mansoni infection

12 November 2019

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1 reference

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5 July 2018

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5 July 2018

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A phase I clinical trial of imiquimod, an oral interferon inducer, administered daily.

5 July 2018

1 reference

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Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

5 July 2018

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Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase

5 July 2018

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Generation of nitric oxide and induction of major histocompatibility complex class II antigen in macrophages from mice lacking the interferon gamma receptor

5 July 2018

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Induction by interleukin-6 of interferon regulatory factor 1 (IRF-1) gene expression through the palindromic interferon response element pIRE and cell type-dependent control of IRF-1 binding to DNA.

5 July 2018

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Functional role of type I and type II interferons in antiviral defense

5 July 2018

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Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide.

5 July 2018

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Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes

5 July 2018

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CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major

5 July 2018

1 reference

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Mice from a genetically resistant background lacking the interferon gamma receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4+ T cell response

5 July 2018

1 reference

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Interferon regulatory factor 1 is required for mouse Gbp gene activation by gamma interferon

5 July 2018

1 reference

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Posttherapy suppression of genital herpes simplex virus (HSV) recurrences and enhancement of HSV-specific T-cell memory by imiquimod in guinea pigs

5 July 2018

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A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

5 July 2018

1 reference

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A novel interferon-inducible domain: structural and functional analysis of the human interferon regulatory factor 1 gene promoter

5 July 2018

1 reference

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Tuberculosis and cancer: parallels in host responses and therapeutic approaches?

5 July 2018

1 reference

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Stimulation of interferon and cytokine gene expression by imiquimod and stimulation by Sendai virus utilize similar signal transduction pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89217

Requirement for transcription factor IRF-1 in NO synthase induction in macrophages.

5 July 2018

1 reference

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The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon

5 July 2018

1 reference

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Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

5 July 2018

1 reference

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Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells

5 July 2018

1 reference

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Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89217

Induction of beta 2-interferon by tumor necrosis factor: a homeostatic mechanism in the control of cell proliferation.

5 July 2018

1 reference

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Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89217

Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes

5 July 2018

1 reference

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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

5 July 2018

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The murine 2-5A synthetase locus: three distinct transcripts from two linked genes

5 July 2018

1 reference

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IL-6 receptor and mechanism of signal transduction

5 July 2018

1 reference

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Interferon regulatory factor-1 (IRF-1) activates the synthetic IRF-1-responsive sequence (GAAAGT)4 in Saccharomyces cerevisiae

5 July 2018

1 reference

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Interferon-dependent signaling pathways: DNA elements, transcription factors, mutations, and effects of viral proteins

5 July 2018

1 reference

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The interferon system. A bird's eye view of its biochemistry

5 July 2018

1 reference

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Critical role of a common transcription factor, IRF-1, in the regulation of IFN-beta and IFN-inducible genes

5 July 2018

1 reference

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Interferon priming. Effects on interferon messenger RNA

5 July 2018

1 reference

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Signaling steps involving the cytoplasmic domain of the interferon-gamma receptor alpha-subunit are not species-specific.

5 July 2018

1 reference

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Involvement of the IRF-1 transcription factor in antiviral responses to interferons

29 October 2018

1 reference

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IL-12 stimulates an antiviral type 1 cytokine response but lacks adjuvant activity in IFN-gamma-receptor-deficient mice

29 October 2018

1 reference

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Development of antimalaria immunity in mice lacking IFN-gamma receptor.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89217

Tumor necrosis factor acts synergistically with autocrine interferon-beta and increases interferon-beta mRNA levels in human fibroblasts

29 October 2018

1 reference

12 December 2020

Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor

1 reference

12 December 2020

Immune response in mice that lack the interferon-gamma receptor

1 reference

12 December 2020

Identification and characterization of an interferon (IFN)-stimulated response element-IFN-stimulated gene factor 3-independent signaling pathway for IFN-alpha

1 reference

12 December 2020

Identifiers

DOI

10.1128/AAC.43.4.856

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10103191%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10103191%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

PubMed publication ID

10103191

1 reference