Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I). (Q33980059)

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30 December 2019

title

Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I) (English)

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2

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author name string

Adrian J Lambert

series ordinal

1

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language of work or name

English

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publication date

15 July 2004

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Journal of Biological Chemistry

30 December 2019

published in

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volume

279

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30 December 2019

page(s)

39414-39420

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issue

38

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Mitochondrial formation of reactive oxygen species

30 December 2019

cites work

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DeltaPsi(m)-Dependent and -independent production of reactive oxygen species by rat brain mitochondria

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Effect of glutathione depletion on sites and topology of superoxide and hydrogen peroxide production in mitochondria.

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The NADH:ubiquinone oxidoreductase (complex I) from Escherichia coli

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The site of production of superoxide radical in mitochondrial Complex I is not a bound ubisemiquinone but presumably iron-sulfur cluster N2.

21 January 2018

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Localization of the site of oxygen radical generation inside the complex I of heart and nonsynaptic brain mammalian mitochondria.

21 January 2018

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Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane

21 January 2018

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Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:ubiquinone oxidoreductase).

21 January 2018

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Superoxide production by the mitochondrial respiratory chain

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Characterization of the complex I-associated ubisemiquinone species: toward the understanding of their functional roles in the electron/proton transfer reaction

21 January 2018

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Energy-dependent Complex I-associated ubisemiquinones in submitochondrial particles.

21 January 2018

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EPR characterization of ubisemiquinones and iron-sulfur cluster N2, central components of the energy coupling in the NADH-ubiquinone oxidoreductase (complex I) in situ

21 January 2018

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Proton-translocation by membrane-bound NADH:ubiquinone-oxidoreductase (complex I) through redox-gated ligand conduction

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M406576200

1 reference

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30 December 2019

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