Virion instability of human immunodeficiency virus type 1 reverse transcriptase (RT) mutated in the protease cleavage site between RT p51 and the RT RNase H domain (Q33987368)

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English	Virion instability of human immunodeficiency virus type 1 reverse transcriptase (RT) mutated in the protease cleavage site between RT p51 and the RT RNase H domain	scientific article

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scholarly article

1 reference

Europe PubMed Central

30 July 2017

Virion instability of human immunodeficiency virus type 1 reverse transcriptase (RT) mutated in the protease cleavage site between RT p51 and the RT RNase H domain (English)

1 reference

Europe PubMed Central

30 July 2017

1 reference

based on heuristic

inferred from title

author name string

Michael E Abram

1

1 reference

Europe PubMed Central

30 July 2017

Michael A Parniak

2

1 reference

Europe PubMed Central

30 July 2017

language of work or name

0 references

publication date

1 September 2005

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Europe PubMed Central

30 July 2017

number of pages

10

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based on heuristic

inferred from page(s)

Journal of Virology

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Europe PubMed Central

30 July 2017

79

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Europe PubMed Central

30 July 2017

18

1 reference

Europe PubMed Central

30 July 2017

11952-11961

1 reference

Europe PubMed Central

30 July 2017

Initial cleavage of the human immunodeficiency virus type 1 GagPol precursor by its activated protease occurs by an intramolecular mechanism

1 reference

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5 July 2018

The dimer interfaces of protease and extra-protease domains influence the activation of protease and the specificity of GagPol cleavage

1 reference

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5 July 2018

Defining HIV-1 protease substrate selectivity

1 reference

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A tight-binding mode of inhibition is essential for anti-human immunodeficiency virus type 1 virucidal activity of nonnucleoside reverse transcriptase inhibitors

1 reference

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Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes

1 reference

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Interaction of human immunodeficiency virus type 1 Vif with Gag and Gag-Pol precursors: co-encapsidation and interference with viral protease-mediated Gag processing

1 reference

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Replication of phenotypically mixed human immunodeficiency virus type 1 virions containing catalytically active and catalytically inactive reverse transcriptase

1 reference

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5 July 2018

How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease

1 reference

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Homodimeric reverse transcriptases from rous sarcoma virus mutated within the polymerase or RNase H active site of one subunit are active

1 reference

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Comparison of human immunodeficiency virus type 1 Pr55(Gag) and Pr160(Gag-pol) processing intermediates that accumulate in primary and transformed cells treated with peptidic and nonpeptidic protease inhibitors

1 reference

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The thumb domain of the P51-subunit is essential for activation of HIV reverse transcriptase

1 reference

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Molecular characterization of proteolytic processing of the Pol proteins of human foamy virus reveals novel features of the viral protease.

1 reference

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Effect of HIV constructs containing protease-reverse transcriptase fusion proteins on viral replication

1 reference

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An enzymatically active chimeric HIV-1 reverse transcriptase (RT) with the RNase-H domain of murine leukemia virus RT exists as a monomer

1 reference

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Inhibition of the ribonuclease H and DNA polymerase activities of HIV-1 reverse transcriptase by N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone

1 reference

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Lack of integrase can markedly affect human immunodeficiency virus type 1 particle production in the presence of an active viral protease

1 reference

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5 July 2018

Proteolytic processing and particle maturation

1 reference

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5 July 2018

Predicting human immunodeficiency virus protease cleavage sites in proteins by a discriminant function method

1 reference

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5 July 2018

Human immunodeficiency virus, type 1 protease substrate specificity is limited by interactions between substrate amino acids bound in adjacent enzyme subsites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

5 July 2018

In vivo processing of Pr160gag-pol from human immunodeficiency virus type 1 (HIV) in acutely infected, cultured human T-lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

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Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex

1 reference

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5 July 2018

Proteolytic activity of novel human immunodeficiency virus type 1 proteinase proteins from a precursor with a blocking mutation at the N terminus of the PR domain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

5 July 2018

The activity of the protease of human immunodeficiency virus type 1 is initiated at the membrane of infected cells before the release of viral proteins and is required for release to occur with maximum efficiency.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

5 July 2018

Kinetics and mechanism of autoprocessing of human immunodeficiency virus type 1 protease from an analog of the Gag-Pol polyprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

5 July 2018

Domains upstream of the protease (PR) in human immunodeficiency virus type 1 Gag-Pol influence PR autoprocessing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

5 July 2018

Generation and characterization of murine monoclonal antibodies reactive against N-terminal and other regions of HIV-1 reverse transcriptase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

5 July 2018

Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

5 July 2018

Human immunodeficiency virus type 1 (HIV-1) recombinant reverse transcriptase. Asymmetry in p66 subunits of the p66/p66 homodimer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

5 July 2018

Human immunodeficiency virus type-1 reverse transcriptase and ribonuclease H as substrates of the viral protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

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Molecular biological characterization of the human foamy virus reverse transcriptase and ribonuclease H domains

1 reference

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5 July 2018

Trans-dominant inhibitory human immunodeficiency virus type 1 protease monomers prevent protease activation and virion maturation

1 reference

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5 July 2018

Structural studies of avian myeloblastosis virus: comparison of polypeptides in virion and core component by dodecyl sulfate-polyacrylamide gel electrophoresis

1 reference

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5 July 2018

A single subunit from avian myeloblastosis virus with both RNA-directed DNA polymerase and ribonuclease H activity

1 reference

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5 July 2018

Proteolytic processing of polyproteins in the replication of RNA viruses

1 reference

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5 July 2018

Mutational analysis of human immunodeficiency virus type 1 protease suggests functional homology with aspartic proteinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

5 July 2018

HIV-1 reverse transcriptase: crystallization and analysis of domain structure by limited proteolysis.

1 reference

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Active site mutagenesis of the AIDS virus protease and its alleviation by trans complementation

1 reference

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Characterization of human immunodeficiency virus type 1 reverse transcriptase by using monoclonal antibodies: role of the C terminus in antibody reactivity and enzyme function.

1 reference

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Identification and characterization of HIV-specific RNase H by monoclonal antibody

1 reference

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Murine leukemia virus pol gene products: analysis with antisera generated against reverse transcriptase and endonuclease fusion proteins expressed in Escherichia coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

5 July 2018

Mutational analysis of a native substrate of the human immunodeficiency virus type 1 proteinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

5 July 2018

Mutating P2 and P1 residues at cleavage junctions in the HIV-1 pol polyprotein. Effects on hydrolysis by HIV-1 proteinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

5 July 2018

Analysis of retroviral protease cleavage sites reveals two types of cleavage sites and the structural requirements of the P1 amino acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

5 July 2018

Subunit-selective mutagenesis indicates minimal polymerase activity in heterodimer-associated p51 HIV-1 reverse transcriptase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

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Proteolytic release and crystallization of the RNase H domain of human immunodeficiency virus type 1 reverse transcriptase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

5 July 2018

Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

5 July 2018

Site-directed mutagenesis of the conserved Asp-443 and Asp-498 carboxy-terminal residues of HIV-1 reverse transcriptase

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Characterization of the human immunodeficiency virus type-1 reverse transcriptase enzyme produced in yeast

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Dimerization of human immunodeficiency virus type 1 reverse transcriptase. A target for chemotherapeutic intervention.

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5 July 2018

Identification of a human immunodeficiency virus-1 protease cleavage site within the 66,000 Dalton subunit of reverse transcriptase

1 reference

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Different requirements for productive interaction between the active site of HIV-1 proteinase and substrates containing -hydrophobic*hydrophobic- or -aromatic*pro- cleavage sites

1 reference

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1 reference

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Human immunodeficiency virus type 1 gag-protease fusion proteins are enzymatically active

1 reference

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Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro

1 reference

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5 July 2018

Conformational changes of HIV reverse transcriptase subunits on formation of the heterodimer: correlation with kcat and Km.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

5 July 2018

Purification and characterization of heterodimeric human immunodeficiency virus type 1 (HIV-1) reverse transcriptase produced by in vitro processing of p66 with recombinant HIV-1 protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

5 July 2018

Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

1 reference

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5 July 2018

Retroviral integrase functions as a multimer and can turn over catalytically

1 reference

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A competition immunoassay for characterizing the reverse transcriptase of mammalian RNA tumor viruses

1 reference

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RNA-dependent DNA polymerase of avian sarcoma virus B77. I. Isolation and partial characterization of the alpha, beta2, and alphabeta forms of the enzyme

1 reference

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5 July 2018

Quantitation of avian RNA tumor virus reverse transcriptase by radioimmunoassay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

5 July 2018

Proteolytic processing of an HIV-1 pol polyprotein precursor: insights into the mechanism of reverse transcriptase p66/p51 heterodimer formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

29 October 2018

Human immunodeficiency virus type 1 capsid protein is a substrate of the retroviral proteinase while integrase is resistant toward proteolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

29 October 2018

Isolation and characterization of Rous sarcoma virus recombinant reverse transcriptase dimers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

29 October 2018

Characterization of human immunodeficiency virus type-1 (HIV-1) particles that express protease-reverse transcriptase fusion proteins

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1212597

29 October 2018

Chimeric HIV-1 and feline immunodeficiency virus reverse transcriptases: critical role of the p51 subunit in the structural integrity of heterodimeric lentiviral DNA polymerases

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29 October 2018

Single-step purification of recombinant wild-type and mutant HIV-1 reverse transcriptase.

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29 October 2018

Extensive regions of pol are required for efficient human immunodeficiency virus polyprotein processing and particle maturation.

1 reference

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29 October 2018

The differential processing of homodimers of reverse transcriptases from human immunodeficiency viruses type 1 and 2 is a consequence of the distinct specificities of the viral proteases.

1 reference

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29 October 2018

Strand displacement activity of the human immunodeficiency virus type 1 reverse transcriptase heterodimer and its individual subunits.

1 reference

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29 October 2018

Biosynthesis and analysis of a genetically engineered HIV-1 reverse transcriptase/endonuclease polyprotein in Escherichia coli

1 reference

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29 October 2018

A molecular clone of HTLV-III with biological activity.

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29 October 2018

A soluble active mutant of HIV-1 integrase: involvement of both the core and carboxyl-terminal domains in multimerization

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12 December 2020

based on heuristic

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Studies on the symmetry and sequence context dependence of the HIV-1 proteinase specificity

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https://pubmed.ncbi.nlm.nih.gov/16140771

12 December 2020

based on heuristic

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HIV protease substrate conformation: modulation by cyclophilin A

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https://pubmed.ncbi.nlm.nih.gov/16140771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reverse Transcriptase Associated with Avian Sarcoma-Leukosis Viruses. I. Comparison of Intra-Virion Content of Multiple Enzyme Forms1

1 reference

https://pubmed.ncbi.nlm.nih.gov/16140771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence specificity of retroviral proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16140771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JVI.79.18.11952-11961.2005

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

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