Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488 (Q33990598)

30 July 2017

title

Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488 (English)

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30 July 2017

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ChEBI release 2020-05-28

Andrew Woodland

3

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Ruth Brenk

Ruth Brenk

9

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Paul G. Wyatt

Paul G Wyatt

14

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Ian H. Gilbert

Ian H Gilbert

13

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Alan Fairlamb

Alan H Fairlamb

10

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Daniel Spinks

4

Daniel Spinks

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30 July 2017

6

Iain T Collie

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30 July 2017

5

Irene Hallyburton

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8

Suzanne Norval

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11

Julie A Frearson

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30 July 2017

Victoria C Smith

1

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Laura A T Cleghorn

2

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N Yi Mok

7

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Kevin D Read

12

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30 July 2017

publication date

10 August 2011

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volume

6

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issue

10

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30 July 2017

page(s)

1832-1840

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Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

30 July 2017

cites work

1 reference

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5 July 2018

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Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial

5 July 2018

1 reference

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Kinetoplastids: related protozoan pathogens, different diseases

5 July 2018

1 reference

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Human African trypanosomiasis: pharmacological re-engagement with a neglected disease.

5 July 2018

1 reference

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Drug discovery and development for neglected parasitic diseases

5 July 2018

1 reference

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The treatment of human African trypanosomiasis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229842

Benzeneacetamide amines: structurally novel non-m.mu. opioids

5 July 2018

1 reference

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Highly selective kappa opioid analgesics. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide and N-[(2-aminocyclohexyl)aryloxy]acetamide derivatives

5 July 2018

1 reference

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Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229842

Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FCMDC.201100278

Chemoenzymatic preparation of optically active trans-cyclohexane-1,2-diamine derivatives: an efficient synthesis of the analgesic U-(-)-50,488.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FCMDC.201100278

Comparison of Shape-Matching and Docking as Virtual Screening Tools

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FCMDC.201100278

Scaffold-hopping potential of ligand-based similarity concepts

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21834094

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/CMDC.201100278

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30 July 2017

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30 July 2017

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