Current and future use of genomics data in toxicology: opportunities and challenges for regulatory applications (Q33992544)

30 July 2017

Current and future use of genomics data in toxicology: opportunities and challenges for regulatory applications (English)

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30 July 2017

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Amber K Goetz

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30 July 2017

Bhanu P Singh

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30 July 2017

Michael Battalora

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30 July 2017

Joseph M Breier

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30 July 2017

Jason P Bailey

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30 July 2017

Amechi C Chukwudebe

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30 July 2017

Erik R Janus

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30 July 2017

language of work or name

English

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publication date

5 August 2011

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Regulatory Toxicology and Pharmacology

30 July 2017

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30 July 2017

61

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30 July 2017

141-153

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30 July 2017

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Improved scoring of functional groups from gene expression data by decorrelating GO graph structure

30 July 2017

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Toxicity profiles in mice treated with hepatotumorigenic and non-hepatotumorigenic triazole conazole fungicides: Propiconazole, triadimefon, and myclobutanil.

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Submission of microarray data to public repositories

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Gene expression in two hepatic cell lines, cultured primary hepatocytes, and liver slices compared to the in vivo liver gene expression in rats: possible implications for toxicogenomics use of in vitro systems

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IPCS framework for analyzing the relevance of a noncancer mode of action for humans

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Hepatic gene expression changes throughout the day in the Fischer rat: implications for toxicogenomic experiments.

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Interlaboratory evaluation of genomic signatures for predicting carcinogenicity in the rat.

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Optimal sampling of rat liver tissue for toxicogenomic studies

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Elucidating the molecular characteristics of organogenesis in human embryos

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Genomic analysis of alachlor-induced oncogenesis in rat olfactory mucosa

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Voluntary exploratory data submissions to the US FDA and the EMA: experience and impact

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Low dose effects of chemicals as assessed by the flow cytometric in vivo micronucleus assay

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Rat toxicogenomic study reveals analytical consistency across microarray platforms

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Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells

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Expression profiling--best practices for data generation and interpretation in clinical trials

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Repeatability of published microarray gene expression analyses

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Multiple-laboratory comparison of microarray platforms

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KEGG: kyoto encyclopedia of genes and genomes

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Ontological analysis of gene expression data: current tools, limitations, and open problems

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Applications of microarrays with toxicologically relevant genes (tox genes) for the evaluation of chemical toxicants in Sprague Dawley rats in vivo and human hepatocytes in vitro

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Expression monitoring by hybridization to high-density oligonucleotide arrays

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Toxicogenomic Study of Triazole Fungicides and Perfluoroalkyl Acids in Rat Livers Predicts Toxicity and Categorizes Chemicals Based on Mechanisms of Toxicity

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Comparison of DNA-adduct and tissue-available dose levels of MeIQx in human and rodent colon following administration of a very low dose

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Discrimination of tumorigenic triazole conazoles from phenobarbital by transcriptional analyses of mouse liver gene expression

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How can toxicogenomics inform risk assessment?

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Performance comparison of one-color and two-color platforms within the MicroArray Quality Control (MAQC) project

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Toxicogenomics in risk assessment: an overview of an HESI collaborative research program

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Current and future applications of toxicogenomics: Results summary of a survey from the HESI Genomics State of Science Subcommittee

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Phenobarbital elicits unique, early changes in the expression of hepatic genes that affect critical pathways in tumor-prone B6C3F1 mice

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Extracting meaning from functional genomics experiments

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Class prediction in toxicogenomics

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Standard and molecular NOAELs for rat testicular toxicity induced by flutamide

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Pieces of the puzzle: expressed sequence tags and the catalog of human genes

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Gene expression profiling of responses to dimethylarsinic acid in female F344 rat urothelium

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Cross-platform comparability of microarray technology: intra-platform consistency and appropriate data analysis procedures are essential

7 January 2021

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The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements

7 January 2021

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Reproducible and reliable microarray results through quality control: good laboratory proficiency and appropriate data analysis practices are essential

7 January 2021

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The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

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A method to integrate benchmark dose estimates with genomic data to assess the functional effects of chemical exposure

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MeIQx-DNA adduct formation in rodent and human tissues at low doses

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Vision & strategy: Predictive ecotoxicology in the 21st century.

7 January 2021

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Transcriptional profiles in liver from mice treated with hepatotumorigenic and nonhepatotumorigenic triazole conazole fungicides: Propiconazole, triadimefon, and myclobutanil.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2011.07.012

Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity

7 January 2021

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Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles

7 January 2021

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Multi-functional gene ASY/Nogo/RTN-X/RTN4: apoptosis, tumor suppression, and inhibition of neuronal regeneration

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Computational toxicology approaches at the US Food and Drug Administration

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10.1016/J.YRTPH.2011.07.012

7 January 2021

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30 July 2017

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