Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta. (Q34006347)

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9 November 2019

review article

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title

Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta (English)

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9 November 2019

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2

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9 November 2019

author name string

W A Beard

series ordinal

1

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9 November 2019

language of work or name

English

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publication date

1 August 2000

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9 November 2019

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9 November 2019

volume

460

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9 November 2019

issue

3-4

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9 November 2019

page(s)

231-244

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Quality control by DNA repair

9 November 2019

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Different DNA polymerases are involved in the short- and long-patch base excision repair in mammalian cells

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Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation.

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Evidence for an imino intermediate in the DNA polymerase beta deoxyribose phosphate excision reaction

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Mapping of the 5'-2-deoxyribose-5-phosphate lyase active site in DNA polymerase beta by mass spectrometry

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DNA polymerase beta in abasic site repair: a structurally conserved helix-hairpin-helix motif in lesion detection by base excision repair enzymes

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Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure

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Functional analysis of the amino-terminal 8-kDa domain of DNA polymerase beta as revealed by site-directed mutagenesis. DNA binding and 5'-deoxyribose phosphate lyase activities

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Catalytic Center of DNA Polymerase β for Excision of Deoxyribose Phosphate Groups†

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Active-site modification of mammalian DNA polymerase beta with pyridoxal 5'-phosphate: mechanism of inhibition and identification of lysine 71 in the deoxynucleoside triphosphate binding pocket

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Structural insights into DNA polymerase beta fidelity: hold tight if you want it right

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Transition between different binding modes in rat DNA polymerase beta-ssDNA complexes

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Impairment of proliferating cell nuclear antigen-dependent apurinic/apyrimidinic site repair on linear DNA.

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Protection against methylation-induced cytotoxicity by DNA polymerase beta-dependent long patch base excision repair

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FEN1 stimulation of DNA polymerase beta mediates an excision step in mammalian long patch base excision repair.

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Backbone dynamics and refined solution structure of the N-terminal domain of DNA polymerase beta. Correlation with DNA binding and dRP lyase activity

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Base substitution specificity of DNA polymerase beta depends on interactions in the DNA minor groove

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Involvement of phenylalanine 272 of DNA polymerase beta in discriminating between correct and incorrect deoxynucleoside triphosphates

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The mutator form of polymerase beta with amino acid substitution at tyrosine 265 in the hinge region displays an increase in both base substitution and frame shift errors

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7 January 2021

Abasic translesion synthesis by DNA polymerase beta violates the "A-rule". Novel types of nucleotide incorporation by human DNA polymerase beta at an abasic lesion in different sequence contexts

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Replication of template-primers containing propanodeoxyguanosine by DNA polymerase beta. Induction of base pair substitution and frameshift mutations by template slippage and deoxynucleoside triphosphate stabilization

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Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps.

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Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).

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Up-regulation of base excision repair correlates with enhanced protection against a DNA damaging agent in mouse cell lines

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DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]

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Functional sites of interaction between release factor RF1 and the ribosome

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Strategic down-regulation of DNA polymerase beta by antisense RNA sensitizes mammalian cells to specific DNA damaging agents

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DNA polymerases alpha and beta are required for DNA repair in an efficient nuclear extract from Xenopus oocytes.

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DNA polymerase beta and DNA synthesis in Xenopus oocytes and in a nuclear extract

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Evidence for a role for DNA polymerase beta in mammalian meiosis

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Changes in the DNA polymerase beta gene expression during development of lung, brain, and testis suggest an involvement of the enzyme in DNA recombination.

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Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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Raster3D: photorealistic molecular graphics

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Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10946231%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

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