C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I. (Q34010567)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11805296%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

title

C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I (English)

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6 December 2019

3

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6 December 2019

author name string

Jihong Bai

series ordinal

1

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6 December 2019

Ping Wang

series ordinal

2

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6 December 2019

language of work or name

English

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publication date

22 January 2002

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Proceedings of the National Academy of Sciences of the United States of America

6 December 2019

published in

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6 December 2019

volume

99

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6 December 2019

issue

3

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6 December 2019

page(s)

1665-1670

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The tandem C2 domains of synaptotagmin contain redundant Ca2+ binding sites that cooperate to engage t-SNAREs and trigger exocytosis.

6 December 2019

cites work

1 reference

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How does calcium trigger neurotransmitter release?

5 July 2018

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Synaptotagmin I functions as a calcium regulator of release probability

5 July 2018

1 reference

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Initial sequencing and analysis of the human genome

5 July 2018

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The C2B domain of synaptotagmin is a Ca(2+)-sensing module essential for exocytosis

5 July 2018

1 reference

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Calcium triggers an intramolecular association of the C2 domains in synaptotagmin

5 July 2018

1 reference

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Crystal structure of the cytosolic C2A-C2B domains of synaptotagmin III. Implications for Ca(+2)-independent snare complex interaction

5 July 2018

1 reference

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Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagmin

5 July 2018

1 reference

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The evolutionary pressure to inactivate. A subclass of synaptotagmins with an amino acid substitution that abolishes Ca2+ binding

5 July 2018

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The C2 domain calcium-binding motif: structural and functional diversity

5 July 2018

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Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin

5 July 2018

1 reference

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C2 domain conformational changes in phospholipase C-delta 1

5 July 2018

1 reference

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A novel function for the second C2 domain of synaptotagmin. Ca2+-triggered dimerization.

5 July 2018

1 reference

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A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding

5 July 2018

1 reference

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Synaptotagmin III is a novel isoform of rat synaptotagmin expressed in endocrine and neuronal cells.

5 July 2018

1 reference

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Calcium dependence of the rate of exocytosis in a synaptic terminal

5 July 2018

1 reference

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The exocytotic fusion pore and neurotransmitter release

5 July 2018

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Synaptotagmin IV is an immediate early gene induced by depolarization in PC12 cells and in brain

5 July 2018

1 reference

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Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold

5 July 2018

1 reference

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Relationship between presynaptic calcium current and postsynaptic potential in squid giant synapse

5 July 2018

1 reference

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Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C

5 July 2018

1 reference

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Synaptotagmin: a calcium sensor on the synaptic vesicle surface.

5 July 2018

1 reference

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Direct interaction of a Ca2+-binding loop of synaptotagmin with lipid bilayers.

5 July 2018

1 reference

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Calcium-dependent oligomerization of synaptotagmins I and II. Synaptotagmins I and II are localized on the same synaptic vesicle and heterodimerize in the presence of calcium.

21 January 2018

1 reference

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Ca2+ regulates the interaction between synaptotagmin and syntaxin 1.

21 January 2018

1 reference

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Synaptic function modulated by changes in the ratio of synaptotagmin I and IV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.032541099

Synaptotagmin modulation of fusion pore kinetics in regulated exocytosis of dense-core vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.032541099

Calcium-dependent interaction of the cytoplasmic region of synaptotagmin with membranes. Autonomous function of a single C2-homologous domain.

21 January 2018

1 reference

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Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranes

29 October 2018

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12 December 2020

Calcium sensitivity of glutamate release in a calyx-type terminal

1 reference

12 December 2020

Membrane-embedded synaptotagmin penetrates cis or trans target membranes and clusters via a novel mechanism

1 reference

12 December 2020

Intracellular calcium dependence of transmitter release rates at a fast central synapse

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12 December 2020

synaptotagmin mutants reveal essential functions for the C2B domain in Ca2+-triggered fusion and recycling of synaptic vesicles in vivo

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12 December 2020

Synthesis and characterization of two fluorescent sulfhydryl reagents

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12 December 2020

Fluorescence studies of the secondary structure and orientation of a model ion channel peptide in phospholipid vesicles

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12 December 2020

Mechanism of phospholipid binding by the C2A-domain of synaptotagmin I

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12 December 2020

Lipid binding ridge on loops 2 and 3 of the C2A domain of synaptotagmin I as revealed by NMR spectroscopy

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12 December 2020

Identifiers

DOI

10.1073/PNAS.032541099

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11805296%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

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release_ubrgjrmyljhmhawmojgksf4kga

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24 November 2022

mapped directly with Wikidata item

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6 December 2019

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