EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity (Q34011075)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20620993%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

title

EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20620993%20AND%20SRC:MED&resulttype=core&format=json

TLDc domain-containing protein CELE_K08E7.1

7 February 2020

main subject

1 reference

GOA release 2020-03-11

1 reference

3

1 reference

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7 February 2020

Patrick J. Hu

7

1 reference

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7 February 2020

6

Shohei Mitani

1 reference

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7 February 2020

author name string

Hena Alam

1

1 reference

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7 February 2020

Travis W Williams

2

1 reference

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7 February 2020

Chunfang Guo

4

1 reference

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7 February 2020

Sawako Yoshina

5

1 reference

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7 February 2020

publication date

1 July 2010

1 reference

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7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20620993%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

volume

12

1 reference

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7 February 2020

issue

1

1 reference

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7 February 2020

page(s)

30-41

1 reference

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FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice

7 February 2020

cites work

1 reference

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FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice

5 July 2018

1 reference

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Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations.

5 July 2018

1 reference

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Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

5 July 2018

1 reference

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Association of FOXO3A variation with human longevity confirmed in German centenarians

5 July 2018

1 reference

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FOXO3A genotype is strongly associated with human longevity

5 July 2018

1 reference

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C. elegans dauer formation and the molecular basis of plasticity

5 July 2018

1 reference

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Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation

5 July 2018

1 reference

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Forkhead transcription factors and ageing

5 July 2018

1 reference

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FOXO animal models reveal a variety of diverse roles for FOXO transcription factors

5 July 2018

1 reference

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The role of FoxO in the regulation of metabolism.

5 July 2018

1 reference

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5 July 2018

1 reference

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Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans

5 July 2018

1 reference

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Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/IGF-1 receptor

5 July 2018

1 reference

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Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity

5 July 2018

1 reference

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Remarkable longevity and stress resistance of nematode PI3K-null mutants

5 July 2018

1 reference

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5 July 2018

1 reference

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SMK-1/PPH-4.1-mediated silencing of the CHK-1 response to DNA damage in early C. elegans embryos

5 July 2018

1 reference

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High-throughput in vivo analysis of gene expression in Caenorhabditis elegans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

The plasticity of aging: insights from long-lived mutants

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation

5 July 2018

1 reference

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C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

5 July 2018

1 reference

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PCR fusion-based approach to create reporter gene constructs for expression analysis in transgenic C. elegans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

Systematic identification of novel protein domain families associated with nuclear functions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

The biology and enzymology of protein N-myristoylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

The diabetes autoantigen ICA69 and its Caenorhabditis elegans homologue, ric-19, are conserved regulators of neuroendocrine secretion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

Regulation of C. elegans life-span by insulinlike signaling in the nervous system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

Signals from the reproductive system regulate the lifespan of C. elegans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway

5 July 2018

1 reference

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Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span

5 July 2018

1 reference

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Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans.

5 July 2018

1 reference

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Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

Negative regulation of the heat shock transcriptional response by HSBP1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

A C. elegans mutant that lives twice as long as wild type

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

The glp-1 locus and cellular interactions in early C. elegans embryos

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

SMK-1, an essential regulator of DAF-16-mediated longevity

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

SDF-9, a protein tyrosine phosphatase-like molecule, regulates the L3/dauer developmental decision through hormonal signaling in C. elegans

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907918

Spatial control of gut-specific gene expression during Caenorhabditis elegans development

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20620993

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20620993

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The genetics of aging

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20620993

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CMET.2010.05.004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20620993%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20620993%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

PubMed publication ID

20620993

1 reference