Somatic cell mutations: can they provide a link between aging and cancer? (Q34013668)

30 July 2017

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title

Somatic cell mutations: can they provide a link between aging and cancer? (English)

1 reference

30 July 2017

Turker MS

1

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PubMed ID

10958919

30 July 2017

language of work or name

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1 August 2000

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Mechanisms of Ageing and Development

30 July 2017

1 reference

30 July 2017

117

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30 July 2017

1-3

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30 July 2017

1-19

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Mutation frequency in human blood cells increases with age

30 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Life span and cancer mortality in the beagle dog and humans

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

In vivo somatic mutations in humans: measurement and analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Mitochondrial decay in aging

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Antioxidant defences against reactive oxygen species causing genetic and other damage

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging?

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

DNA damage and mutation: contributors to the age-related alterations in T cell-mediated immune responses?

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

The free radical theory of aging matures

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

High levels of patched gene mutations in basal-cell carcinomas from patients with xeroderma pigmentosum

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

DNA damage, mutation and fine structure DNA repair in aging.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Sunlight and the onset of skin cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Oxidative mutagens induce intrachromosomal recombination in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Mammalian DNA mismatch repair

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

A checkpoint on the road to cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving X-irradiation: association with delayed reproductive death phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Biology of aging as related to cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Ageing, cancer, and mitochondrial deterioration

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Chromosome Aberrations in Liver Cells of Dogs of Different Ages

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

The specificity of p53 mutation spectra in sunlight induced human cancers.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Repair of oxidative damage to DNA: enzymology and biology

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Effect of dietary restriction on in vivo somatic mutation in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Rapid accumulation of genome rearrangements in liver but not in brain of old mice

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Can we predict solar ultraviolet radiation as the causal event in human tumours by analysing the mutation spectra of the p53 gene?

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

The influence of an aging immune system on cancer incidence and progression

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

A genetic model for colorectal tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Novel DNA polymerases offer clues to the molecular basis of mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

The error catastrophe theory of aging. Point counterpoint

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Dietary supplements of antioxidants reduce hprt mutant frequency in splenocytes of aging mice

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Aging processes, DNA damage, and repair.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

In vivo human somatic mutation: frequency and spectrum with age

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Mutagenesis by 8-oxoguanine: an enemy within

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Clonal analysis of delayed karyotypic abnormalities and gene mutations in radiation-induced genetic instability

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Mechanisms of chemically induced renal carcinogenesis in the laboratory rodent

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Telomeres and telomerase in aging and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Aging: a theory based on free radical and radiation chemistry

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Free radical theory of aging

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Free-radical theory of aging. Increasing the functional life span

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Mutagenicity of arsenic in mammalian cells: role of reactive oxygen species

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

1 reference

7 January 2021

Clonal chromosome aberrations and genomic instability in X-irradiated human T-lymphocyte cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

A cloning assay for 6-thioguanine resistance provides evidence against certain somatic mutational theories of aging

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Aging, DNA methylation and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

On the origin of multiple mutations in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Induction of microsatellite instability by oxidative DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Human aging is associated with stochastic somatic mutations of mitochondrial DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Transmission of chromosomal instability after plutonium α-particle irradiation

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Radiation-induced genomic instability: delayed cytogenetic aberrations and apoptosis in primary human bone marrow cells

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Loss of constitutional heterozygosity in human cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

p53 mutations increase resistance to ionizing radiation

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

DNA damage, oncogenesis and the p53 tumour-suppressor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Comparative analysis of DNA mutations in lacI transgenic mice with age.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Gene expression profile of aging and its retardation by caloric restriction

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Genetic instability in colorectal cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Genetic instability and the mutator phenotype. Studies in ulcerative colitis

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Mitotic misregulation and human aging

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Delayed chromosomal instability induced by DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Somatic mutagenesis and antimutagenesis in aging research

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Genetic analysis of ageing: role of oxidative damage and environmental stresses.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Somatic mutations are frequent and increase with age in human kidney epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Use of transgenic mouse models for studying somatic mutations in aging

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Mismatch repair in replication fidelity, genetic recombination, and cancer biology

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

DNA double-strand breaks, chromosomal rearrangements, and genomic instability

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Human lymphocytes resistant to 6-thioguanine increase with age.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Loss of heterozygosity induced by a chromosomal double-strand break

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Mapping the end points of large deletions affecting the hprt locus in human peripheral blood cells and cell lines.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Mutations in the p53 gene occur in diverse human tumour types

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Accelerated accumulation of somatic mutations in the senescence-accelerated mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Spontaneous mutant frequency of lacZ gene in spleen of transgenic mouse increases with age

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Ageing of Clones of Mammalian Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Mitochondrial DNA mutations associated with aging and degenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Mutation, ageing, and ovarian cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Genetic alterations distinguish different types of ovarian tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Genetic alterations on chromosome 17 distinguish different types of epithelial ovarian tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

The mitotic machinery as a source of genetic instability in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Accumulation of mtDNA defects and changes in mtDNA content in mouse and rat tissues with aging

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Somatic mutations of the mitochondrial genome in human colorectal tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Tandem double CC-->TT mutations are produced by reactive oxygen species

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Mutagenesis by metal-induced oxygen radicals

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Cell aging in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Multiple deletions are detectable in mitochondrial DNA of aging mice

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Inactivation of OGG1 increases the incidence of G . C-->T . A transversions in Saccharomyces cerevisiae: evidence for endogenous oxidative damage to DNA in eukaryotic cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Loss of heterozygosity or: how I learned to stop worrying and love mitotic recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

The mutation rate and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Persistent oxidative stress in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Estimation of mutation frequencies in normal mammalian cells and the development of cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

A cell line selected for resistance to ionizing radiation exhibits cross resistance to other genotoxic agents and a mutator phenotype for loss of heterozygosity events

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

The molecular basis of oncogenes and tumor suppressor genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

1 reference

7 January 2021

Genomic instability is an early event during the progression pathway of ulcerative-colitis-related neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Cancer in the aged. An epidemiologic perspective on treatment issues

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Mutagenesis induced by the tumor microenvironment

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

Factors affecting somatic mutation frequencies in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

The natural somatic mutation frequency and human carcinogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2800%2900133-0

7 January 2021

10.1016/S0047-6374(00)00133-0

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

10958919