Adhesion-linked kinases in cancer; emphasis on src, focal adhesion kinase and PI 3-kinase (Q34013783)

30 July 2017

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title

Adhesion-linked kinases in cancer; emphasis on src, focal adhesion kinase and PI 3-kinase (English)

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30 July 2017

R J Jones

1

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PubMed ID

10959046

30 July 2017

V G Brunton

series ordinal

2

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PubMed ID

10959046

30 July 2017

M C Frame

series ordinal

3

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30 July 2017

1 August 2000

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European Journal of Cancer

30 July 2017

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30 July 2017

36

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30 July 2017

13 Spec No

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30 July 2017

1595-1606

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A SARCOMA OF THE FOWL TRANSMISSIBLE BY AN AGENT SEPARABLE FROM THE TUMOR CELLS

30 July 2017

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https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Association of p60c-src with endosomal membranes in mammalian fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Cooperation of Src homology domains in the regulated binding of phosphatidylinositol 3-kinase. A role for the Src homology 2 domain

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Association between the PDGF receptor and members of the src family of tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Src family kinases are required for integrin but not PDGFR signal transduction.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

The catalytic activity of the Src family kinases is required to disrupt cadherin-dependent cell-cell contacts

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https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Src and Ras are involved in separate pathways in epithelial cell scattering

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https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

DNA synthesis induced by some but not all growth factors requires Src family protein tyrosine kinases.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Cell transformation by the viral src oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

A target for Src in mitosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Overexpression of c-Src enhances cell-matrix adhesion and cell migration in PDGF-stimulated NIH3T3 fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Progression of familial adenomatous polyposis (FAP) colonic cells after transfer of the src or polyoma middle T oncogenes: cooperation between src and HGF/Met in invasion

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Overexpression of pp60c-src elicits invasive behavior in rat colon epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

A role for epidermal growth factor receptor, c-Src and focal adhesion kinase in an in vitro model for the progression of colon cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Regulation of both apoptosis and cell survival by the v-Src oncoprotein.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

New roles for Src kinases in control of cell survival and angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential

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https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Different metastatic potentials of ras- and src-transformed BALB/c 3T3 A31 variant cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Activating SRC mutation in a subset of advanced human colon cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

c-Src protein expression is increased in human breast cancer. An immunohistochemical and biochemical analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Overexpression and activation of the tyrosine kinase Src in human pancreatic carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Elevated c-Src tyrosine kinase activity in premalignant epithelia of ulcerative colitis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Activation of Src in human breast tumor cell lines: elevated levels of phosphotyrosine phosphatase activity that preferentially recognizes the Src carboxy terminal negative regulatory tyrosine 530

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin

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https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Chicken and mouse focal adhesion kinases are similar in structure at their amino termini.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Expression of an N-terminally truncated form of human focal adhesion kinase in brain

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https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains

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https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase

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https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration

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https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK

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https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

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https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

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https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

v-Src induces tyrosine phosphorylation of focal adhesion kinase independently of tyrosine 397 and formation of a complex with Src

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Structural differences between repressed and derepressed forms of p60c-src

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Focal adhesion kinase mediates the integrin signaling requirement for growth factor activation of MAP kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Focal adhesion kinase (p125FAK): a point of convergence in the action of neuropeptides, integrins, and oncogenes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Inhibition of cell spreading by expression of the C-terminal domain of focal adhesion kinase (FAK) is rescued by coexpression of Src or catalytically inactive FAK: a role for paxillin tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

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https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Control of adhesion-dependent cell survival by focal adhesion kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Cleavage of focal adhesion kinase by caspases during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Focal adhesion kinase (p125FAK) expression correlates with motility of human melanoma cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Expression of focal adhesion kinase gene and invasive cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Activation of the focal adhesion kinase signal transduction pathway in cervical carcinoma cell lines and human genital epithelial cells immortalized with human papillomavirus type 18

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Focal adhesion kinase (pp125FAK) expression, activation and association with paxillin and p50CSK in human metastatic prostate carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Overexpression of focal adhesion kinase (p125FAK) in human colorectal carcinoma liver metastases: independence from c-src or c-yes activation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Phosphoinositide kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Oncogenes and signal transduction

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https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Intracellular movement of green fluorescent protein-tagged phosphatidylinositol 3-kinase in response to growth factor receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Rho: a connection between membrane receptor signalling and the cytoskeleton.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Cellular survival: a play in three Akts

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https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Role of translocation in the activation and function of protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900153-2

7 January 2021

10.1016/S0959-8049(00)00153-2

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

10959046