A retrospect on the discovery of WAY-100635 and the prospect for improved 5-HT(1A) receptor PET radioligands (Q34016383)

30 July 2017

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title

A retrospect on the discovery of WAY-100635 and the prospect for improved 5-HT(1A) receptor PET radioligands (English)

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30 July 2017

Cliffe IA

1

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30 July 2017

publication date

1 July 2000

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Nuclear Medicine and Biology

30 July 2017

published in

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30 July 2017

volume

27

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30 July 2017

issue

5

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30 July 2017

page(s)

441-447

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(S)-N-tert-butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors

30 July 2017

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WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors

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7 January 2021

Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist

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A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635

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Buspirone: Action on serotonin receptors in calf hippocampus

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Evaluation of [O-methyl-3H]WAY-100635 as an in vivo radioligand for 5-HT1A receptors in rat brain

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7 January 2021

Receptor binding characteristics of [3H]NAD-299, a new selective 5-HT1A receptor antagonist

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7 January 2021

New 5-HT1A receptor antagonist: [3H]p-MPPF.

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Development of fluorine-18-labeled 5-HT1A antagonists.

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High-yield radiosynthesis and preliminary in vivo evaluation of p-[18F]MPPF, a fluoro analog of WAY-100635.

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Characterization of the radioactive metabolites of the 5-HT1A receptor radioligand, [O-methyl-11C]WAY-100635, in monkey and human plasma by HPLC: comparison of the behaviour of an identified radioactive metabolite with parent radioligand in monkey u

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Positron-emitting radioligands for studies in vivo-probes for human psychopharmacology

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[carbonyl-11C]Desmethyl-WAY-100635 (DWAY) is a potent and selective radioligand for central 5-HT1A receptors in vitro and in vivo.

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7 January 2021

Radioligands for the study of brain 5-HT(1A) receptors in vivo--development of some new analogues of way.

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7 January 2021

First delineation of 5-HT1A receptors in human brain with PET and [11C]WAY-100635

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7 January 2021

Exquisite delineation of 5-HT1A receptors in human brain with PET and [carbonyl-11C]WAY-100635

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7 January 2021

[18F]p-MPPF: A Radiolabeled Antagonist for the Study of 5-HT1A Receptors with PET

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7 January 2021

The 5-HT1A antagonist WAY-100635 selectively potentiates the presynaptic effects of serotonergic antidepressants in rat brain.

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7 January 2021

Radiosynthesis and autoradiographic evaluation of [11C]NAD-299, a radioligand for visualization of the 5-HT1A receptor.

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7 January 2021

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7 January 2021

In vivo biodistribution of a radiotracer for imaging serotonin-1A receptor sites with PET:[11C]LY274601.

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7 January 2021

[18F]fluoroalkyl analogues of the potent 5-HT1A antagonist WAY 100635: radiosyntheses and in vivo evaluation

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7 January 2021

Derivatives of WAY 100635 as potential imaging agents for 5-HT1A receptors: syntheses, radiosyntheses, and in vitro and in vivo evaluation.

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Synthesis and evaluation of 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p- iodobenzamido]ethyl]piperazine (p-MPPI): a new iodinated 5-HT1A ligand

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7 January 2021

10.1016/S0969-8051(00)00109-8

Identifiers

DOI

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30 July 2017

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