Functional polymorphism of the mu-opioid receptor gene (OPRM1) influences reinforcement learning in humans (Q34017870)

30 July 2017

Functional polymorphism of the mu-opioid receptor gene (OPRM1) influences reinforcement learning in humans (English)

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30 July 2017

reinforcement learning

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5

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30 July 2017

Mary R Lee

1

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30 July 2017

Courtney L Gallen

2

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30 July 2017

Xiaochu Zhang

3

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30 July 2017

Colin A Hodgkinson

4

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30 July 2017

Elliot A Stein

6

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30 July 2017

Christina S Barr

7

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30 July 2017

language of work or name

English

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publication date

2 September 2011

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30 July 2017

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30 July 2017

6

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30 July 2017

9

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30 July 2017

e24203

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Creative Commons CC0 License

30 July 2017

start time

2 September 2011

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April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

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cites work

Neuropathic and chronic pain stimuli downregulate central mu-opioid and dopaminergic transmission

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

Genetic variation in dopaminergic neuromodulation influences the ability to rapidly and flexibly adapt decisions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

Reward processing by the opioid system in the brain.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

Variation in the mu-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

Mu opioid receptor modulation of somatodendritic dopamine overflow: GABAergic and glutamatergic mechanisms

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

Ethnicity and OPRM variant independently predict pain perception and patient-controlled analgesia usage for post-operative pain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

Dopamine DRD2 polymorphism alters reversal learning and associated neural activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

Variation in dopamine genes influences responsivity of the human reward system

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

Single dose of a dopamine agonist impairs reinforcement learning in humans: evidence from event-related potentials and computational modeling of striatal-cortical function

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

Addictions biology: haplotype-based analysis for 130 candidate genes on a single array

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

Reduced hedonic capacity in major depressive disorder: evidence from a probabilistic reward task

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

Genetic variation in human NPY expression affects stress response and emotion

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

Single dose of a dopamine agonist impairs reinforcement learning in humans: behavioral evidence from a laboratory-based measure of reward responsiveness

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

Increased perceived stress is associated with blunted hedonic capacity: potential implications for depression research

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

Toward an objective characterization of an anhedonic phenotype: a signal-detection approach

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

A mu-opioid receptor single nucleotide polymorphism in rhesus monkey: association with stress response and aggression

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

Serotonin transporter genetic variation and the response of the human amygdala

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

Endogenous opioids and reward

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

Opioids excite dopamine neurons by hyperpolarization of local interneurons.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

The G allele of SNP E1/A118G at the mu-opioid receptor gene locus shows genomic evidence of recent positive selection

28 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024203

Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024203

Suppression of alcohol preference by naltrexone in the rhesus macaque: a critical role of genetic variation at the micro-opioid receptor gene locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024203

Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024203

Reinforcer control and human signal-detection performance

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024203

Increased gabaergic input to ventral tegmental area dopaminergic neurons associated with decreased cocaine reinforcement in mu-opioid receptor knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024203

Decreased firing frequency of midbrain dopamine neurons in mice lacking mu opioid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024203

Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the mu-opioid receptor locus (OPRM1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024203

Regional mu opioid receptor regulation of sensory and affective dimensions of pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024203

The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166306

10.1371/JOURNAL.PONE.0024203

29 October 2018

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DOI

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30 July 2017

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30 July 2017

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