Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta (Q34020577)

30 July 2017

title

Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta (English)

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30 July 2017

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2

Markus Heimesaat

1 reference

30 July 2017

David Q Shih

1

1 reference

30 July 2017

Satoru Kuwajima

3

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30 July 2017

Roland Stein

4

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30 July 2017

Christopher V E Wright

5

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30 July 2017

Markus Stoffel

6

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30 July 2017

language of work or name

English

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publication date

1 March 2002

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Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

published in

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30 July 2017

volume

99

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30 July 2017

issue

6

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30 July 2017

page(s)

3818-3823

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A transcription factor regulatory circuit in differentiated pancreatic cells

30 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122607

Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism

28 July 2018

1 reference

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Developmental biology of the pancreas.

28 July 2018

1 reference

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Functional conservation of regulatory elements in the pdx-1 gene: PDX-1 and hepatocyte nuclear factor 3beta transcription factors mediate beta-cell-specific expression

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122607

Regulation of insulin gene transcription

28 July 2018

1 reference

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Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

28 July 2018

1 reference

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Variant hepatocyte nuclear factor 1 is required for visceral endoderm specification

28 July 2018

1 reference

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Essential role for the homeoprotein vHNF1/HNF1beta in visceral endoderm differentiation

28 July 2018

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Pancreatic beta-cell-to-beta-cell interactions are required for integrated responses to nutrient stimuli: enhanced Ca2+ and insulin secretory responses of MIN6 pseudoislets.

28 July 2018

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Pancreas development and diabetes

28 July 2018

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beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes

28 July 2018

1 reference

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Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells

28 July 2018

1 reference

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A causal role for E-cadherin in the transition from adenoma to carcinoma

28 July 2018

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Nucleosome positioning by the winged helix transcription factor HNF3

28 July 2018

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Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia

28 July 2018

1 reference

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A pancreatic beta -cell-specific enhancer in the human PDX-1 gene is regulated by hepatocyte nuclear factor 3beta (HNF-3beta ), HNF-1alpha, and SPs transcription factors

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122607

Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.

29 October 2018

1 reference

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Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3beta sites

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122607

An early developmental transcription factor complex that is more stable on nucleosome core particles than on free DNA.

29 October 2018

1 reference

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Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122607

Regulation of a transcription factor network required for differentiation and metabolism

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122607

Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122607

Cadherins regulate aggregation of pancreatic beta-cells in vivo.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122607

The role of hepatic nuclear factor 1 alpha and PDX-1 in transcriptional regulation of the pdx-1 gene

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11904435

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11904435

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11904435

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.062605899

1 reference

30 July 2017

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1 reference

30 July 2017

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