Herpes simplex virus type 1 and Alzheimer's disease: increasing evidence for a major role of the virus (Q34026390)

30 July 2017

Herpes simplex virus type 1 and Alzheimer's disease: increasing evidence for a major role of the virus (English)

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Herpes simplex virus type 1

30 July 2017

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Ruth F Itzhaki

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30 July 2017

11 August 2014

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Frontiers in Aging Neuroscience

30 July 2017

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30 July 2017

6

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30 July 2017

202

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Reactivated herpes simplex infection increases the risk of Alzheimer's disease

30 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Increased inflammatory response in cytomegalovirus seropositive patients with Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Inflammatory and neurodegeneration markers during asymptomatic HSV-1 reactivation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Persistent viral pathogens and cognitive impairment across the life course in the third national health and nutrition examination survey.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Novel treatment with neuroprotective and antiviral properties against a neuroinvasive human respiratory virus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Titers of herpes simplex virus type 1 antibodies positively correlate with grey matter volumes in Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Susceptibility genes are enriched in those of the herpes simplex virus 1/host interactome in psychiatric and neurological disorders.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

The helicase-primase inhibitor BAY 57-1293 reduces the Alzheimer's disease-related molecules induced by herpes simplex virus type 1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Synthesis and comparison of the meta-analyses evaluating the efficacy of memantine in moderate to severe stages of Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Virological and immunological characteristics of human cytomegalovirus infection associated with Alzheimer disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Infectious burden and cognitive function: the Northern Manhattan Study

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

HSV, axonal transport and Alzheimer's disease: in vitro and in vivo evidence for causal relationships

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Increase in the IgG avidity index due to herpes simplex virus type 1 reactivation and its relationship with cognitive function in amnestic mild cognitive impairment and Alzheimer's disease.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Reactivation of herpes simplex virus type 1 is associated with cytomegalovirus and age

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Exposure to herpes simplex virus type 1 and cognitive impairments in individuals with schizophrenia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Association between IgM anti-herpes simplex virus and plasma amyloid-beta levels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Antivirals reduce the formation of key Alzheimer's disease molecules in cell cultures acutely infected with herpes simplex virus type 1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Inflammation induced by infection potentiates tau pathological features in transgenic mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Herpes simplex virus dances with amyloid precursor protein while exiting the cell

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Antiviral agents in Alzheimer's disease: hope for the future?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Alzheimer's disease gene signature says: beware of brain viral infections

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

APP processing induced by herpes simplex virus type 1 (HSV-1) yields several APP fragments in human and rat neuronal cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from HIV+ patients with and without dementia.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

APOE genotype is associated with oral herpetic lesions but not genital or oral herpes simplex virus shedding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Effect of high versus low oral doses of valacyclovir on herpes simplex virus-1 DNA shedding into tears of latently infected rabbits

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Seropositivity to herpes simplex virus antibodies and risk of Alzheimer's disease: a population-based cohort study

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Apolipoprotein E-epsilon 4 and recurrent genital herpes in individuals co-infected with herpes simplex virus type 2 and HIV.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Effect of apolipoprotein E on the cerebral load of latent herpes simplex virus type 1 DNA

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Fast anterograde transport of herpes simplex virus: role for the amyloid precursor protein of alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Impact of viral and bacterial burden on cognitive impairment in elderly persons with cardiovascular diseases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Cytomegalovirus is present in a very high proportion of brains from vascular dementia patients.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Review of 3200 serially received CSF samples submitted for type-specific HSV detection by PCR in the reference laboratory setting

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Herpes simplex virus type 1 in brain and risk of Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

"Limbic predilection in Alzheimer dementia: is reactivated herpesvirus involved?".

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Mild forms of herpes encephalitis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

A sero-epidemiological study of conventional infectious agents in Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Detection of HSV1 DNA by in situ hybridisation in human brain after immunosuppression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Viruses in human brains: a search for cytomegalovirus and herpes virus 1 DNA in necropsy tissue from normal and neuropsychiatric cases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Viruses, brain and immunosuppression.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128394

Accelerated Tau deposition in the brains of individuals infected with human immunodeficiency virus-1 before and after the advent of highly active anti-retroviral therapy.

5 July 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00202

Cutting edge: TLR2-mediated proinflammatory cytokine and chemokine production by microglial cells in response to herpes simplex virus

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00202

Pathological tau proteins in postencephalitic parkinsonism: comparison with Alzheimer's disease and other neurodegenerative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00202

ApoE4 is more efficient than E3 in brain access by herpes simplex virus type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00202

Central nervous system herpes simplex and varicella zoster virus infections in natalizumab-treated patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00202

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00202

Cytomegalovirus: an improbable cause of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00202

Could antivirals be used to treat Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00202

Latent herpes simplex virus type 1 in normal and Alzheimer's disease brains

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00202

Cerebrospinal fluid Alzheimer's biomarker profiles in CNS infections.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00202

Tau cleavage at D421 by caspase-3 is induced in neurons and astrocytes infected with herpes simplex virus type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00202

Gene signature in Alzheimer's disease and environmental factors: the virus chronicle

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00202

Herpesviruses in brain and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00202

Interaction of herpesviridae, APOE gene, and education in cognitive impairment.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00202

Herpes simplex virus type 1 induces simultaneous activation of Toll-like receptors 2 and 4 and expression of the endogenous ligand serum amyloid A in astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00202

Intravenous immunoglobulin reduces β amyloid and abnormal tau formation caused by herpes simplex virus type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00202

Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00202

Productive herpes simplex virus in brain of elderly normal subjects and Alzheimer's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00202

21 January 2018

Identifiers

DOI

10.3389/FNAGI.2014.00202

1 reference

30 July 2017

1 reference

30 July 2017

1 reference

PubMed ID

25157230