Why is PTPN22 a good candidate susceptibility gene for autoimmune disease? (Q34026657)

30 July 2017

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title

Why is PTPN22 a good candidate susceptibility gene for autoimmune disease? (English)

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30 July 2017

Andrew P Cope

5

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author name string

Garth L Burn

1

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30 July 2017

Lena Svensson

2

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30 July 2017

Cristina Sanchez-Blanco

3

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30 July 2017

Manoj Saini

4

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30 July 2017

language of work or name

English

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publication date

20 April 2011

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30 July 2017

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30 July 2017

585

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30 July 2017

3689-3698

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30 July 2017

23

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Protein tyrosine phosphatase non-receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population

30 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

The 1858T PTPN22 gene variant contributes to a genetic risk of type 1 diabetes in a Ukrainian population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Differential association of the PTPN22 coding variant with autoimmune diseases in a Dutch population

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Genetic association between a lymphoid tyrosine phosphatase (PTPN22) and type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Sex-specific association of PTPN22 1858T with type 1 diabetes but not with Hashimoto's thyroiditis or Addison's disease in the German population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

PTPN22 C1858T polymorphism in Colombian patients with autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Association of the PTPN22 C1858T single-nucleotide polymorphism with rheumatoid arthritis phenotypes in an inception cohort.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Association of the PTPN22 locus with rheumatoid arthritis in a New Zealand Caucasian cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus: a meta-analysis update

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Lymphoid tyrosine phosphatase (PTPN22/LYP) variant and Graves' disease in a Polish population: association and gene dose-dependent correlation with age of onset

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Mutation screening of PTPN22: association of the 1858T-allele with Addison's disease

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Association of the PTPN22*R620W polymorphism with autoimmune myasthenia gravis.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

A single-nucleotide polymorphism in the gene encoding lymphoid protein tyrosine phosphatase (PTPN22) confers susceptibility to generalised vitiligo

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

The PTPN22-1858C>T (R620W) functional polymorphism is associated with generalized vitiligo in the Romanian population

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Association of PTPN22 1858C/T polymorphism with vitiligo susceptibility in Gujarat population.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Protein tyrosine phosphatases and the immune response

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Molecular basis of the motheaten phenotype

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Recent advances in the genetics of autoimmune disease

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Replication validity of genetic association studies

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Deep resequencing reveals excess rare recent variants consistent with explosive population growth

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

No independent role of the -1123 G>C and+2740 A>G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

No evidence for association between 1858 C/T single-nucleotide polymorphism of PTPN22 gene and primary Sjögren's syndrome

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

PTPN22: setting thresholds for autoimmunity

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Tempo and mode in the endocannaboinoid system.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Genetic Influence of PTPN22 R620W Polymorphism in Tuberculosis

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Association of PTPN22 gene functional variants with development of pulmonary tuberculosis in Moroccan population

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

PTPN22 C1858T polymorphism and the outcome of hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Association study of PTPN22 C1858T polymorphism in Trypanosoma cruzi infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

PTPN22 C1858T polymorphism and human brucellosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Regulation of lymphoid tyrosine phosphatase activity: inhibition of the catalytic domain by the proximal interdomain

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Identification of a variant form of tyrosine phosphatase LYP

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

The tipping points in the initiation of B cell signalling: how small changes make big differences.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Positive and negative regulation of T-cell activation through kinases and phosphatases

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Association of protein-tyrosine phosphatase MEG2 via its Sec14p homology domain with vesicle-trafficking proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Localization of PTP-FERM in nerve processes through its FERM domain

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Identification of substrates of human protein-tyrosine phosphatase PTPN22

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Subcellular localization of intracellular protein tyrosine phosphatases in T cells

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

A weak Lck tail bite is necessary for Lck function in T cell antigen receptor signaling.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Sequence requirements for association of protein-tyrosine phosphatase PEP with the Src homology 3 domain of inhibitory tyrosine protein kinase p50(csk)

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

The tyrosine kinase Csk dimerizes through Its SH3 domain

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Csk-mediated phosphorylation of substrates is regulated by substrate tyrosine phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Constitutively active Lck kinase in T cells drives antigen receptor signal transduction

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Genetically encoded Förster resonance energy transfer sensors for the conformation of the Src family kinase Lck.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Protein tyrosine phosphatases in T cell physiology.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

HLA , CTLA-4 and PTPN22 : the shared genetic master-key to autoimmunity?

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

The Vav family: at the crossroads of signaling pathways

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Combination of gene targeting and substrate trapping to identify substrates of protein tyrosine phosphatases using PTP-PEST as a model

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Reduced CD4+T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

PTPN22 R620W promotes production of anti-AChR autoantibodies and IL-2 in myasthenia gravis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Protein tyrosine phosphatases: from genes, to function, to disease

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Crystal Structure of the Human Lymphoid Tyrosine Phosphatase Catalytic Domain: Insights into Redox Regulation,

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Pathogenic autoantibodies in lupus nephritis

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

PTPN22 gene regulates natural killer cell proliferation during in vitro expansion

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

Natural killer cells in human autoimmunity

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

PTPN22 and invasive bacterial disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.032

10.1016/J.FEBSLET.2011.04.032

21 January 2018

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30 July 2017

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