Case studies of minimizing nonspecific inhibitors in HTS campaigns that use assay-ready plates (Q34028228)

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title

Case studies of minimizing nonspecific inhibitors in HTS campaigns that use assay-ready plates (English)

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Yichin Liu

1

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Maureen H Beresini

2

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Adam Johnson

3

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Robert Mintzer

4

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Kinjalkumar Shah

5

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Kevin Clark

6

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Stephen Schmidt

7

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Cristina Lewis

8

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Marya Liimatta

9

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Linda O Elliott

10

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Amy Gustafson

11

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Christopher E Heise

12

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publication date

22 September 2011

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Journal of Biomolecular Screening

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published in

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volume

17

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issue

2

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page(s)

225-236

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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cites work

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https://api.crossref.org/works/10.1177%2F1087057111421525

Divergent modes of enzyme inhibition in a homologous structure-activity series

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057111421525

Stability and equilibria of promiscuous aggregates in high protein milieus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111421525

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111421525

A specific mechanism of nonspecific inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111421525

Promiscuous aggregate-based inhibitors promote enzyme unfolding

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111421525

High-throughput assays for promiscuous inhibitors.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057111421525

A detergent-based assay for the detection of promiscuous inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111421525

A high-throughput screen for aggregation-based inhibition in a large compound library

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111421525

Effect of detergent on "promiscuous" inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111421525

Interpreting steep dose-response curves in early inhibitor discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111421525

Efficient elimination of nonstoichiometric enzyme inhibitors from HTS hit lists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111421525

Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111421525

Identification and Prediction of Promiscuous Aggregating Inhibitors among Known Drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111421525

NMR-based quality control approach for the identification of false positives and false negatives in high throughput screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111421525

Colloidal aggregate detection by rapid fluorescence measurement of liquid surface curvature changes in multiwell plates

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111421525

Screening in a spirit haunted world

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057111421525

21 January 2018

Identifiers

DOI

10.1177/1087057111421525

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30 July 2017

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