Functionalized congeners of P2Y1 receptor antagonists: 2-alkynyl (N)-methanocarba 2'-deoxyadenosine 3',5'-bisphosphate analogues and conjugation to a polyamidoamine (PAMAM) dendrimer carrier (Q34029528)

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English	Functionalized congeners of P2Y1 receptor antagonists: 2-alkynyl (N)-methanocarba 2'-deoxyadenosine 3',5'-bisphosphate analogues and conjugation to a polyamidoamine (PAMAM) dendrimer carrier	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Functionalized congeners of P2Y1 receptor antagonists: 2-alkynyl (N)-methanocarba 2'-deoxyadenosine 3',5'-bisphosphate analogues and conjugation to a polyamidoamine (PAMAM) dendrimer carrier (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Sonia de Castro

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Sonia de Castro

1

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Stefano Costanzi

object named as

Stefano Costanzi

5

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Kenneth A. Jacobson

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Kenneth A Jacobson

10

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author name string

Hiroshi Maruoka

2

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Europe PubMed Central

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30 July 2017

Kunlun Hong

3

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Europe PubMed Central

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30 July 2017

S Michael Kilbey

4

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Europe PubMed Central

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30 July 2017

Béatrice Hechler

6

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Europe PubMed Central

PubMed publication ID

30 July 2017

Garth G Brown

7

1 reference

Europe PubMed Central

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30 July 2017

Christian Gachet

8

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Europe PubMed Central

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30 July 2017

T Kendall Harden

9

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Europe PubMed Central

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30 July 2017

publication date

1 July 2010

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Europe PubMed Central

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30 July 2017

Bioconjugate Chemistry

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Europe PubMed Central

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30 July 2017

21

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Europe PubMed Central

PubMed publication ID

30 July 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

1190-1205

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Europe PubMed Central

PubMed publication ID

30 July 2017

Quantification of recombinant and platelet P2Y(1) receptors utilizing a [(125)I]-labeled high-affinity antagonist 2-iodo-N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([(125)I]MRS2500)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912410

5 July 2018

Polyamidoamine (PAMAM) dendrimer conjugates of "clickable" agonists of the A3 adenosine receptor and coactivation of the P2Y14 receptor by a tethered nucleotide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912410

5 July 2018

PEGylated dendritic unimolecular micelles as versatile carriers for ligands of G protein-coupled receptors

1 reference

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5 July 2018

Enhanced potency of nucleotide-dendrimer conjugates as agonists of the P2Y14 receptor: multivalent effect in G protein-coupled receptor recognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912410

5 July 2018

Growing applications of "click chemistry" for bioconjugation in contemporary biomedical research

1 reference

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5 July 2018

Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912410

5 July 2018

Functionalized congener approach to the design of ligands for G protein-coupled receptors (GPCRs).

1 reference

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Novel antiplatelet agents in development: prasugrel, ticagrelor, and cangrelor and beyond

1 reference

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Enhanced A3 adenosine receptor selectivity of multivalent nucleoside-dendrimer conjugates.

1 reference

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5 July 2018

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

1 reference

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5 July 2018

Structure of a beta1-adrenergic G-protein-coupled receptor

1 reference

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5 July 2018

On the applicability of GPCR homology models to computer-aided drug discovery: a comparison between in silico and crystal structures of the beta2-adrenergic receptor.

1 reference

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5 July 2018

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

1 reference

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5 July 2018

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

1 reference

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5 July 2018

P2Y1 receptor switches to neurons from glia in juvenile versus neonatal rat cerebellar cortex

1 reference

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The Sonogashira reaction: a booming methodology in synthetic organic chemistry.

1 reference

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5 July 2018

Dendrimers as multi-purpose nanodevices for oncology drug delivery and diagnostic imaging

1 reference

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5 July 2018

International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy

1 reference

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5 July 2018

Regulation of platelet functions by P2 receptors

1 reference

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5 July 2018

[32P]2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([32P]MRS2500), a novel radioligand for quantification of native P2Y1 receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912410

5 July 2018

MRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y1 receptor with strong antithrombotic activity in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912410

5 July 2018

Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912410

5 July 2018

Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912410

5 July 2018

Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors

1 reference

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The growing impact of click chemistry on drug discovery

1 reference

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2-Substitution of Adenine Nucleotide Analogues Containing a Bicyclo[3.1.0]hexane Ring System Locked in a Northern Conformation: Enhanced Potency as P2Y1 Receptor Antagonists

1 reference

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Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist

1 reference

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Enantioselective synthesis of bicyclo[3.1.0]hexane carbocyclic nucleosides via a lipase-catalyzed asymmetric acetylation. Characterization of an unusual acetal byproduct

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Key role of the P2Y(1) receptor in tissue factor-induced thrombin-dependent acute thromboembolism: studies in P2Y(1)-knockout mice and mice treated with a P2Y(1) antagonist

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Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice

1 reference

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Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation

1 reference

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Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2'-deoxyadenosine 3',5'-bisphosphate

1 reference

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Adenosine nucleotides acting at the human P2Y1 receptor stimulate mitogen-activated protein kinases and induce apoptosis

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10.1021/BC900569U

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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