The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo (Q34029869)

30 July 2017

title

The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo (English)

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chronic lymphocytic leukemia

30 July 2017

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ChEBI release 2020-05-28

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6

William G Wierda

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8

Susan O'Brien

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7

Michael J Keating

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10

Jan A Burger

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4

Kumudha Balakrishnan

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9

Nicholas Chiorazzi

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30 July 2017

Sabine Ponader

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30 July 2017

Shih-Shih Chen

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2

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Joseph J Buggy

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3

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Varsha Gandhi

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5

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30 July 2017

language of work or name

English

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publication date

16 December 2011

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volume

119

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issue

5

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30 July 2017

page(s)

1182-1189

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Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765.

30 July 2017

cites work

1 reference

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5 July 2018

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5 July 2018

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The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

5 July 2018

1 reference

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

5 July 2018

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Expression of Bruton's agammaglobulinemia tyrosine kinase gene, BTK, is selectively down-regulated in T lymphocytes and plasma cells.

5 July 2018

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5 July 2018

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29 October 2018

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29 October 2018

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29 October 2018

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29 October 2018

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Expression of Bruton's tyrosine kinase protein within the B cell lineage

29 October 2018

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Bruton's Tyrosine Kinase and Phospholipase Cγ2 Mediate Chemokine-Controlled B Cell Migration and Homing

29 October 2018

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29 October 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/22180443

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1182/BLOOD-2011-10-386417

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30 July 2017

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30 July 2017

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