After 130 years, the molecular mechanism of action of nitroglycerin is revealed (Q34029878)

30 July 2017

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title

After 130 years, the molecular mechanism of action of nitroglycerin is revealed (English)

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30 July 2017

1

Louis J Ignarro

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PubMed ID

12060725

30 July 2017

language of work or name

English

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publication date

1 June 2002

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Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

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30 July 2017

99

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30 July 2017

7816-7817

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30 July 2017

12

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Identification of the enzymatic mechanism of nitroglycerin bioactivation

30 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122975

Inhibition of NADPH-cytochrome P450 reductase and glyceryl trinitrate biotransformation by diphenyleneiodonium sulfate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122975

Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122975

Sulfhydryl requirement for relaxation of vascular smooth muscle

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122975

Erythrocyte aldehyde dehydrogenase and disulfiram-like side effects of hypoglycemics and antianginals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122975

Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122975

Organic nitrate metabolism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122975

Guanylate cyclase: activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122975

Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122975

Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite possible involvement of S-nitrosothiols

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.132271799

Inactivation of human aldehyde dehydrogenase by isosorbide dinitrate

21 January 2018

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12 December 2020

Nitrate tolerance in vivo is not associated with depletion of arterial or venous thiol levels

1 reference

12 December 2020

Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions

1 reference

12 December 2020

Nitroglycerin tolerance in human vessels: evidence for impaired nitroglycerin bioconversion

1 reference

12 December 2020

Mechanism of tolerance development to organic nitrates

1 reference

12 December 2020

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates

1 reference

12 December 2020

Antagonism of glycerol trinitrate activity by an inhibitor of glutathione S-transferase

1 reference

12 December 2020

Purification and characterization of glutathione transferases with an activity toward nitroglycerin from human aorta and heart. Multiplicity of the human class Mu forms

1 reference

12 December 2020

Cytochrome P-450 mediated biotransformation of organic nitrates

1 reference

12 December 2020

Biotransformation of glyceryl trinitrate by rat aortic cytochrome P450

1 reference

12 December 2020

Biochemical characterization of a membrane-bound enzyme responsible for generating nitric oxide from nitroglycerin in vascular smooth muscle cells

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.132271799

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30 July 2017

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30 July 2017

1 reference

PubMed ID

12060725