The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease (Q34033179)

30 July 2017

title

The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease (English)

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30 July 2017

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9

Douglas T Golenbock

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30 July 2017

2

Philipp Henneke

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30 July 2017

3

Alberto Visintin

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30 July 2017

Amit Srivastava

1

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30 July 2017

Sarah C Morse

4

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30 July 2017

Victoria Martin

5

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30 July 2017

Claire Watkins

6

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30 July 2017

James C Paton

7

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30 July 2017

Michael R Wessels

8

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30 July 2017

Richard Malley

10

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30 July 2017

language of work or name

English

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publication date

1 October 2005

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30 July 2017

published in

Infection and Immunity

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30 July 2017

volume

73

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30 July 2017

issue

10

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30 July 2017

page(s)

6479-6487

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Bacterial programmed cell death of cerebral endothelial cells involves dual death pathways

30 July 2017

cites work

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5 July 2018

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5 July 2018

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CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection.

5 July 2018

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5 July 2018

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5 July 2018

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Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense

5 July 2018

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5 July 2018

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Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis

5 July 2018

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Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction

5 July 2018

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5 July 2018

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Endogenous pro- and anti-inflammatory cytokines differentially regulate an in vivo humoral response to Streptococcus pneumoniae.

5 July 2018

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Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis

5 July 2018

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Modification of lipid A biosynthesis in Neisseria meningitidis lpxL mutants: influence on lipopolysaccharide structure, toxicity, and adjuvant activity

5 July 2018

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Intranasal immunization with killed unencapsulated whole cells prevents colonization and invasive disease by capsulated pneumococci

5 July 2018

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Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling

5 July 2018

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The autolytic enzyme LytA of Streptococcus pneumoniae is not responsible for releasing pneumolysin

5 July 2018

1 reference

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Visualizing pneumococcal infections in the lungs of live mice using bioluminescent Streptococcus pneumoniae transformed with a novel gram-positive lux transposon

5 July 2018

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Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection

5 July 2018

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Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

5 July 2018

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Host cellular immune response to pneumococcal lung infection in mice.

5 July 2018

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Group A Streptococcus induces apoptosis in human epithelial cells

5 July 2018

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Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2

5 July 2018

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Pneumolysin, a protein toxin of Streptococcus pneumoniae, induces nitric oxide production from macrophages

5 July 2018

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Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2

5 July 2018

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5 July 2018

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The regulation of apoptosis by microbial pathogens.

5 July 2018

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Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction

5 July 2018

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Neuroprotection by a caspase inhibitor in acute bacterial meningitis

5 July 2018

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

5 July 2018

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Bacterial meningitis in the United States in 1995. Active Surveillance Team

5 July 2018

1 reference

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Identification of the gene encoding the Escherichia coli lipid A 4'-kinase. Facile phosphorylation of endotoxin analogs with recombinant LpxK.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1230904

Molecular and cellular mechanisms of pneumococcal meningitis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1230904

Role of tumor necrosis factor alpha in pathogenesis of pneumococcal pneumonia in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1230904

The contribution of pneumolysin to the pathogenicity of Streptococcus pneumoniae

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1230904

Acute bacterial meningitis in adults. A review of 493 episodes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1230904

Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1230904

Effects of pneumolysin on human polymorphonuclear leukocytes and platelets

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1230904

The relative role of bacterial cell wall and capsule in the induction of inflammation in pneumococcal meningitis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1230904

The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1230904

Alveolar Macrophage Apoptosis Contributes to Pneumococcal Clearance in a Resolving Model of Pulmonary Infection

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1230904

Streptococcus pneumoniae-associated human macrophage apoptosis after bacterial internalization via complement and Fcgamma receptors correlates with intracellular bacterial load.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1230904

Reactivation of latent tuberculosis infection in TNF-deficient mice

29 October 2018

1 reference

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Two distinct mechanisms for induction of dendritic cell apoptosis in response to intact Streptococcus pneumoniae

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1230904

Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1230904

Pneumolysin activates the synthesis and release of interleukin-8 by human neutrophils in vitro.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1230904

Respiratory syncytial virus inhibits apoptosis and induces NF-kappa B activity through a phosphatidylinositol 3-kinase-dependent pathway

29 October 2018

1 reference

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Pharmacologic interference with NF-kappaB activation attenuates central nervous system complications in experimental Pneumococcal meningitis.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1230904

Respiratory syncytial virus infection induces expression of the anti-apoptosis gene IEX-1L in human respiratory epithelial cells.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1230904

Studies on the structure and mechanism of a bacterial protein toxin by analytical ultracentrifugation and small-angle neutron scattering.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1230904

Community-acquired bacterial meningitis: risk stratification for adverse clinical outcome and effect of antibiotic timing.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1230904

Three-year multicenter surveillance of pneumococcal meningitis in children: clinical characteristics, and outcome related to penicillin susceptibility and dexamethasone use.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1230904

Requirement of TNF and TNF receptor type 2 for LPS-induced protection from lethal septic peritonitis

29 October 2018

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12 December 2020

Inhibition of human monocyte respiratory burst, degranulation, phospholipid methylation and bactericidal activity by pneumolysin

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12 December 2020

Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli

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12 December 2020

Dual Phases of Apoptosis in Pneumococcal Meningitis

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12 December 2020

10.1128/IAI.73.10.6479-6487.2005

Identifiers

DOI

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30 July 2017

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30 July 2017

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