Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site (Q34041148)

30 July 2017

title

Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site (English)

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30 July 2017

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J H Matthews

1

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30 July 2017

R Krishnan

2

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30 July 2017

M J Costanzo

3

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30 July 2017

B E Maryanoff

4

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30 July 2017

A Tulinsky

5

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30 July 2017

language of work or name

English

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publication date

1 November 1996

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30 July 2017

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30 July 2017

volume

71

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30 July 2017

issue

5

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30 July 2017

page(s)

2830-2839

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Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an alpha-keto-amide transition-state mimetic

30 July 2017

cites work

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Active site and exosite binding of alpha-thrombin.

28 July 2018

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A player of many parts: the spotlight falls on thrombin's structure.

28 July 2018

1 reference

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Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6

28 July 2018

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Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes

28 July 2018

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Structure of a retro-binding peptide inhibitor complexed with human alpha-thrombin

28 July 2018

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The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin

28 July 2018

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Thrombin inhibitors. 2. Amide derivatives of N alpha-substituted L-arginine

28 July 2018

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Aromatic-aromatic interaction: a mechanism of protein structure stabilization

28 July 2018

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The geometries of interacting arginine-carboxyls in proteins

28 July 2018

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Free energy via molecular simulation: applications to chemical and biomolecular systems

28 July 2018

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The roles of protein C and thrombomodulin in the regulation of blood coagulation

28 July 2018

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The structure of a complex of recombinant hirudin and human alpha-thrombin

28 July 2018

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Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition

28 July 2018

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28 July 2018

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Structure of the hirugen and hirulog 1 complexes of alpha-thrombin

28 July 2018

1 reference

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Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors

28 July 2018

1 reference

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The coagulation cascade: initiation, maintenance, and regulation

28 July 2018

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Refined structure of the hirudin-thrombin complex

28 July 2018

1 reference

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Geometry of binding of the N alpha-tosylated piperidides of m-amidino-, p-amidino- and p-guanidino phenylalanine to thrombin and trypsin. X-ray crystal structures of their trypsin complexes and modeling of their thrombin complexes

28 July 2018

1 reference

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Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin

28 July 2018

1 reference

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Synthesis of a homologous series of ketomethylene arginyl pseudodipeptides and application to low molecular weight hirudin-like thrombin inhibitors

28 July 2018

1 reference

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Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1233769

Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation

28 July 2018

1 reference

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The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1233769

A new series of synthetic thrombin-inhibitors (OM-inhibitors) having extremely potent and selective action

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1233769

Interactions of a fluorescent active-site-directed inhibitor of thrombin: dansylarginine N-(3-ethyl-1,5-pentanediyl)amide

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1233769

Active-site mimetic inhibition of thrombin

28 July 2018

1 reference

12 December 2020

Molecular recognition by thrombin. Role of the slow-->fast transition, site-specific ion binding energetics and thermodynamic mapping of structural components

1 reference

12 December 2020

Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics

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12 December 2020

Mechanism of action of thrombin on fibrinogen. Kinetic evidence for involvement of aspartic acid at position P10

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12 December 2020

The Na+ binding site of thrombin

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12 December 2020

The mechanism of the fibrinogen-thrombin reaction

1 reference

12 December 2020

Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl++ +) sulfonyl]-l-arginyl)]-2-piperidinecarboxylic acid

1 reference

12 December 2020

Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C

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12 December 2020

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12 December 2020

The action of thrombin on peptide p-nitroanilide substrates. Substrate selectivity and examination of hydrolysis under different reaction conditions

1 reference

12 December 2020

Structure of N-terminal Fragments of Fibrinogen and Specificity of Thrombin

1 reference

12 December 2020

In vitro and in vivo studies of a new series of synthetic thrombin-inhibitors (OM-inhibitors)

1 reference

12 December 2020

Potent thrombin inhibitors that probe the S1 subsite: tripeptide transition state analogues based on a heterocycle-activated carbonyl group

1 reference

12 December 2020

Stereochemically restrained refinement of macromolecular structures

1 reference

12 December 2020

10.1016/S0006-3495(96)79479-1

Identifiers

DOI

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30 July 2017

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30 July 2017

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