Liver alkaline phosphatase: a missing link between choleresis and biliary inflammation (Q34043010)

30 July 2017

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title

Liver alkaline phosphatase: a missing link between choleresis and biliary inflammation (English)

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30 July 2017

1

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language of work or name

English

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publication date

24 February 2015

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30 July 2017

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30 July 2017

61

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30 July 2017

6

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30 July 2017

2080-2090

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Levels of alkaline phosphatase and bilirubin are surrogate end points of outcomes of patients with primary biliary cirrhosis: an international follow-up study

30 July 2017

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The biliary HCO(3)(-) umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies

21 January 2018

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A biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes.

21 January 2018

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The human alkaline phosphatases: what we know and what we don't know

21 January 2018

1 reference

Alkaline phosphatase isozymes: recent progress

21 January 2018

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Alkaline Phosphatases : Structure, substrate specificity and functional relatedness to other members of a large superfamily of enzymes

21 January 2018

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Cellular function and molecular structure of ecto-nucleotidases.

21 January 2018

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Intestinal alkaline phosphatase: multiple biological roles in maintenance of intestinal homeostasis and modulation by diet

21 January 2018

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Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase

21 January 2018

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Basolateral internalization of GPI-anchored proteins occurs via a clathrin-independent flotillin-dependent pathway in polarized hepatic cells

21 January 2018

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Factors affecting the ability of glycosylphosphatidylinositol-specific phospholipase D to degrade the membrane anchors of cell surface proteins

21 January 2018

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Interpretation and clinical significance of alkaline phosphatase isoenzyme patterns

21 January 2018

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The role of the liver in clearance of glycoproteins from the general circulation, with special reference to intestinal alkaline phosphatase

21 January 2018

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Intestinal alkaline phosphatase in bile: evidence for an enterohepatic circulation

21 January 2018

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On the role and fate of LPS-dephosphorylating activity in the rat liver

21 January 2018

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Prophylactic treatment with alkaline phosphatase in cardiac surgery induces endogenous alkaline phosphatase release

21 January 2018

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Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

21 January 2018

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Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes

21 January 2018

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Serum enzymes associated with cholestasis

21 January 2018

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A novel hypothesis for an alkaline phosphatase 'rescue' mechanism in the hepatic acute phase immune response.

21 January 2018

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Association between serum alkaline phosphatase and C-reactive protein in the United States National Health and Nutrition Examination Survey 2005-2006.

21 January 2018

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Liver enzymes and risk of all-cause mortality in general populations: a systematic review and meta-analysis.

21 January 2018

1 reference

Induction of rat liver alkaline phosphatase: the mechanism of the serum elevation in bile duct obstruction.

21 January 2018

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Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression

21 January 2018

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Characterisation of patients with a complete biochemical response to ursodeoxycholic acid

21 January 2018

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Characterisation of patients with primary biliary cirrhosis responding to long term ursodeoxycholic acid treatment

21 January 2018

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Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic Acid

21 January 2018

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Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis

21 January 2018

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Baseline ductopenia and treatment response predict long-term histological progression in primary biliary cirrhosis

21 January 2018

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Purinergic signalling in the liver in health and disease

21 January 2018

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Isolated rat hepatocytes can signal to other hepatocytes and bile duct cells by release of nucleotides

21 January 2018

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Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile

21 January 2018

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Ursodeoxycholic acid stimulates cholangiocyte fluid secretion in mice via CFTR-dependent ATP secretion

21 January 2018

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Intestinal alkaline phosphatase regulates protective surface microclimate pH in rat duodenum

21 January 2018

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Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung

21 January 2018

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Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8

21 January 2018

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Purinergic regulation of acid/base transport in human and rat biliary epithelial cell lines

21 January 2018

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Defective regulation of cholangiocyte Cl-/HCO3(-) and Na+/H+ exchanger activities in primary biliary cirrhosis.

21 January 2018

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Loss of Inositol 1,4,5-trisphosphate receptors from bile duct epithelia is a common event in cholestasis

21 January 2018

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Proinflammatory cytokines inhibit secretion in rat bile duct epithelium.

21 January 2018

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Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes

21 January 2018

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Differential expression of canalicular membrane Ca2+/Mg(2+)-ecto-ATPase in estrogen-induced and obstructive cholestasis in the rat.

21 January 2018

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Lipopolysaccharide alters ecto-ATP-diphosphohydrolase and causes relocation of its reaction product in experimental intrahepatic cholestasis

21 January 2018

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Altered cytokine production in mice lacking P2X(7) receptors

21 January 2018

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Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response

21 January 2018

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Extracellular ATP and P2X7 receptors in neurodegeneration

21 January 2018

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Major histocompatibility complex class I shedding and programmed cell death stimulated through the proinflammatory P2X7 receptor: a candidate susceptibility gene for NOD diabetes.

21 January 2018

1 reference

Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation.

21 January 2018

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Nucleotide signalling during inflammation

21 January 2018

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Extracellular ATP in the immune system: more than just a "danger signal".

21 January 2018

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ATP drives lamina propria T(H)17 cell differentiation

21 January 2018

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Roles of proinflammatory cytokines and the Fas/Fas ligand interaction in the pathogenesis of inflammatory myopathies

21 January 2018

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Relation between Escherichia coli R(rough)-forms in gut, lipid A in liver, and primary biliary cirrhosis

21 January 2018

1 reference

Are antimitochondrial antibodies in primary biliary cirrhosis induced by R(rough)-mutants of enterobacteriaceae?

21 January 2018

1 reference

Biliary innate immunity: function and modulation

21 January 2018

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Immune response to lipopolysaccharide in primary biliary cirrhosis and autoimmune diseases

21 January 2018

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Mucosal immunity in liver autoimmunity: a comprehensive review

21 January 2018

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Hepatic expression of multiple acute phase proteins and down-regulation of nuclear receptors after acute endotoxin exposure.

21 January 2018

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LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process.

21 January 2018

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Cholangiocyte N-Ras protein mediates lipopolysaccharide-induced interleukin 6 secretion and proliferation

21 January 2018

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Advances in cholangiocyte immunobiology

21 January 2018

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Increased iNOS activity is essential for hepatic epithelial tight junction dysfunction in endotoxemic mice

21 January 2018

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Cholangiocyte senescence by way of N-ras activation is a characteristic of primary sclerosing cholangitis

21 January 2018

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Alkaline phosphatases reduce toxicity of lipopolysaccharides in vivo and in vitro through dephosphorylation

21 January 2018

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Removal of phosphate from lipid A as a strategy to detoxify lipopolysaccharide

21 January 2018

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Effects of Differences in Lipid A Structure on TLR4 Pro-Inflammatory Signaling and Inflammasome Activation.

21 January 2018

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Primary biliary cirrhosis: a 2010 update

21 January 2018

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Ursodeoxycholic acid and bile-acid mimetics as therapeutic agents for cholestatic liver diseases: an overview of their mechanisms of action

21 January 2018

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Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis

21 January 2018

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IL-17A synergistically enhances bile acid-induced inflammation during obstructive cholestasis

21 January 2018

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Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO⁻₃ output

21 January 2018

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Anticholestatic effects of bezafibrate in patients with primary biliary cirrhosis treated with ursodeoxycholic acid

21 January 2018

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Effects of three different fibrates on intrahepatic cholestasis experimentally induced in rats.

21 January 2018

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Peroxisome proliferators-activated alpha agonist treatment ameliorates hepatic damage in rats with obstructive jaundice: an experimental study

21 January 2018

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Sumoylated PPARalpha mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice

21 January 2018

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Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells

21 January 2018

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All-trans-retinoic acid improves cholestasis in α-naphthylisothiocyanate-treated rats and Mdr2-/- mice

21 January 2018

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Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood

21 January 2018

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Purinergic signaling during inflammation

21 January 2018

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Adenosine receptors as drug targets--what are the challenges?

21 January 2018

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Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2-/- mice

21 January 2018

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Differential effects of norUDCA and UDCA in obstructive cholestasis in mice

21 January 2018

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Corticosteroids modulate the secretory processes of the rat intrahepatic biliary epithelium.

21 January 2018

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Budesonide combined with UDCA to improve liver histology in primary biliary cirrhosis: a three-year randomized trial

21 January 2018

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Triple therapy with ursodeoxycholic acid, budesonide and mycophenolate mofetil in patients with features of severe primary biliary cirrhosis not responding to ursodeoxycholic acid alone

21 January 2018

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Intestinal alkaline phosphatase: novel functions and protective effects

21 January 2018

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Intestinal alkaline phosphatase prevents metabolic syndrome in mice

21 January 2018

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Intestinal alkaline phosphatase promotes gut bacterial growth by reducing the concentration of luminal nucleotide triphosphates

21 January 2018

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Characterization of animal models for primary sclerosing cholangitis (PSC).

21 January 2018

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Editorial: further evidence for the role of serum alkaline phosphatase as a useful surrogate marker of prognosis in PSC

21 January 2018

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7 January 2021

Mammalian alkaline phosphatases are allosteric enzymes

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7 January 2021

Elimination of alkaline phosphatases from circulation by the galactose receptor. Different isoforms are cleared at various rates

1 reference

7 January 2021

The function of alkaline phosphatase in the liver: regulation of intrahepatic biliary epithelium secretory activities in the rat

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7 January 2021

Allotype immunoglobulin enhances alkaline phosphatase activity: implications for the inflammatory response

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7 January 2021

Regulation of alkaline phosphatase gene expression in human hepatoma cells by bile acids

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7 January 2021

Bile acid-dependent secretion of alkaline phosphatase in rat bile

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7 January 2021

Association of canalicular membrane enzymes with bile acid micelles and lipid aggregates in human and rat bile

1 reference

7 January 2021

Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia

1 reference

7 January 2021

Assessment of biliary bicarbonate secretion in humans by positron emission tomography

1 reference

7 January 2021

Modulation of P2X7 nucleotide receptor expression by pro- and anti-inflammatory stimuli in THP-1 monocytes.

1 reference

7 January 2021

Abnormal accumulation of endotoxin in biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis

1 reference

7 January 2021

Ursodeoxycholic acid in cholestasis: potential mechanisms of action and therapeutic applications

1 reference

7 January 2021

Selective Activation of Nuclear Bile Acid Receptor FXR in the Intestine Protects Mice Against Cholestasis

1 reference

7 January 2021

Oral budesonide and ursodeoxycholic acid for treatment of primary biliary cirrhosis: results of a prospective double-blind trial

1 reference

7 January 2021

Identifiers

DOI

10.1002/HEP.27715

1 reference

30 July 2017

1 reference

PubMed ID

25603770