Baicalein Protects against Type 2 Diabetes via Promoting Islet β-Cell Function in Obese Diabetic Mice. (Q34043054)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147566%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

title

Baicalein Protects against Type 2 Diabetes via Promoting Islet β-Cell Function in Obese Diabetic Mice (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147566%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

0 references

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147566%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

Dongmin Liu

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147566%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

author name string

Yu Fu

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147566%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

Zhenquan Jia

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147566%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

Wei Zhen

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147566%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

Kequan Zhou

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147566%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

Elizabeth Gilbert

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147566%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

publication date

23 July 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147566%20AND%20SRC:MED&resulttype=core&format=json

International journal of endocrinology

13 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147566%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

volume

2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147566%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

page(s)

846742

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147566%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 3.0 Unported

13 March 2020

copyright license

start time

1 January 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

cites work

Development of a nongenetic mouse model of type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Antioxidants in the treatment of diabetes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes: implications for therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

The genus Scutellaria an ethnopharmacological and phytochemical review

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Autoimmune mechanisms in type 1 diabetes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5'-AMP-activated protein kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Molecular control of cell cycle progression in the pancreatic beta-cell

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Effects of flavonoids extracted from Scutellaria baicalensis Georgi on hemin-nitrite-H2O2 induced liver injury

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Genistein acutely stimulates insulin secretion in pancreatic beta-cells through a cAMP-dependent protein kinase pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Diabetes mellitus in the elderly: insulin resistance and/or impaired insulin secretion?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Weight gain and insulin treatment

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Herb-drug interactions: a literature review

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Biological properties of baicalein in cardiovascular system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Type 2 diabetes: principles of pathogenesis and therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

The development of beta-cell mass: recent progress and potential role of GLP-1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Cellular mechanism for potentiation of Ca2+-mediated Cl- secretion by the flavonoid baicalein in intestinal epithelia.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

The novel anti-inflammatory compound, lisofylline, prevents diabetes in multiple low-dose streptozotocin-treated mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Pharmacological treatment of chronic diabetes by stimulating pancreatic beta-cell regeneration with systemic co-administration of EGF and gastrin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Glucose-stimulated signaling pathways in biphasic insulin secretion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Induction of cyclooxygenase-2 gene in pancreatic beta-cells by 12-lipoxygenase pathway product 12-hydroxyeicosatetraenoic acid

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Natural and hemisynthetic neoclerodane diterpenoids from scutellaria and their antifeedant activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Baicalin reduces mitochondrial damage in streptozotocin-induced diabetic Wistar rats

5 July 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F846742

Baicalein, a natural product, selectively activating AMPKα(2) and ameliorates metabolic disorder in diet-induced mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F846742

Treatment of diabetic neuropathy with baicalein: intervention at multiple sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F846742

Baicalein reduces inflammatory process in a rodent model of diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F846742

Human cytomegalovirus-inhibitory flavonoids: studies on antiviral activity and mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F846742

Production of cytokines and stimulation of resistance to viral infection in human leukocytes by Scutellaria baicalensis flavones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F846742

Nitrite-glucose-glucose oxidase system directly induces rat heart homogenate oxidation and tyrosine nitration: effects of some flavonoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F846742

Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F846742

Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F846742

Combination therapy with epidermal growth factor and gastrin increases beta-cell mass and reverses hyperglycemia in diabetic NOD mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F846742

Obesity and type 2 diabetes impair insulin-induced suppression of glycogenolysis as well as gluconeogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F846742

Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F846742

Genistein and daidzein prevent diabetes onset by elevating insulin level and altering hepatic gluconeogenic and lipogenic enzyme activities in non-obese diabetic (NOD) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F846742

Genistein and daidzein modulate hepatic glucose and lipid regulating enzyme activities in C57BL/KsJ-db/db mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F846742

Mechanistic study on the intestinal absorption and disposition of baicalein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F846742

Absorption and enterohepatic circulation of baicalin in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F846742

Interaction of baicalin and baicalein with antibiotics in the gastrointestinal tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F846742

Flavonol kaempferol improves chronic hyperglycemia-impaired pancreatic beta-cell viability and insulin secretory function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F846742

Effects of scutellarin on liver function after brain ischemia/reperfusion in rats

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132321

Upregulation of insulin receptor substrate-2 in pancreatic β cells prevents diabetes

28 October 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F846742

Two flavone 2'-glucosides from Scutellaria baicalensis

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25147566

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Decreased glucose-induced cAMP and insulin release in islets of diabetic rats: reversal by IBMX, glucagon, GIP

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25147566

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Investigation of the absorption mechanisms of baicalin and baicalein in rats

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25147566

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1155/2014/846742

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147566%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147566%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147566%20AND%20SRC:MED&resulttype=core&format=json