Apolipoprotein E and Alzheimer disease: an update on genetic and functional analyses (Q34045304)

30 July 2017

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title

Apolipoprotein E and Alzheimer disease: an update on genetic and functional analyses (English)

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30 July 2017

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Saunders AM

1

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30 July 2017

publication date

1 September 2000

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Journal of Neuropathology & Experimental Neurology

30 July 2017

published in

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30 July 2017

volume

59

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30 July 2017

issue

9

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30 July 2017

page(s)

751-758

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Apolipoprotein E, epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region.

30 July 2017

cites work

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Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation

21 January 2018

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Cerebrospinal fluid proteins studied by two-dimensional gel electrophoresis and immunoblotting technique

21 January 2018

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Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP).

21 January 2018

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Specific regional transcription of apolipoprotein E in human brain neurons

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Apolipoprotein E, survival in Alzheimer's disease patients, and the competing risks of death and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Accelerated decline in apolipoprotein E-epsilon4 homozygotes with Alzheimer's disease

21 January 2018

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Alzheimer's disease and possible gene interaction.

21 January 2018

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Amyloid angiopathy in a Volga German family with Alzheimer's disease and a presenilin-2 mutation (N141I).

21 January 2018

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Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop

21 January 2018

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The apolipoprotein E allele epsilon 4 is overrepresented in patients with the Lewy body variant of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Alzheimer's disease with and without coexisting Parkinson's disease changes: apolipoprotein E genotype and neuropathologic correlates.

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Apo E genotypes in multiple sclerosis, Parkinson's disease, schwannomas and late-onset Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Apolipoprotein E genotyping in the differential diagnosis, not prediction, of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease.

21 January 2018

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Apolipoprotein-E genotyping in diagnosis of Alzheimer's disease.

21 January 2018

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Apolipoprotein E genotypes in a neuropathological series from the Consortium to Establish a Registry for Alzheimer's Disease.

21 January 2018

1 reference

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Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Apolipoprotein E ε4 allele is associated with deposition of amyloid β-protein following head injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Neuronal cytoskeletal changes are an early consequence of repetitive head injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Tau pathology in two Dutch families with mutations in the microtubule-binding region of tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Reelin is a ligand for lipoprotein receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Apolipoprotein E allele epsilon 4 is linked to increased deposition of the amyloid beta-peptide (A-beta) in cases with or without Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Apolipoprotein E genotype and deposits of Abeta40 and Abeta42 in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Abeta-peptide length and apolipoprotein E genotype in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Apolipoprotein E forms stable complexes with recombinant Alzheimer's disease beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Native complex formation between apolipoprotein E isoforms and the Alzheimer's disease peptide A beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Amino-terminus truncated apolipoprotein E is the major species in amyloid deposits in Alzheimer's disease-affected brains: a possible role for apolipoprotein E in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

On the metabolism of apolipoprotein E and the Alzheimer diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Human apolipoprotein E accelerates microtubule polymerization in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Neurodegeneration in the central nervous system of apoE-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Neurodegeneration and cognitive impairment in apoE-deficient mice is ameliorated by infusion of recombinant apoE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Severe learning deficits in apolipoprotein E-knockout mice in a water maze task.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Apolipoprotein-E deficiency results in an altered stress responsiveness in addition to an impaired spatial memory in young mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

Phosphorylation of tau protein is not affected in mice lacking apolipoprotein E

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

ApoE as a prognostic factor for post–traumatic coma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.9.751

21 January 2018

Identifiers

DOI

10.1093/JNEN/59.9.751

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30 July 2017

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