Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII. (Q34048086)

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6 January 2020

title

Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII (English)

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6 January 2020

1

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6 January 2020

Norelle L Daly

4

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6 January 2020

K. Johan Rosengren

5

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6 January 2020

Frederic A Meunier

7

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6 January 2020

David J. Adams

8

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6 January 2020

David Craik

9

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6 January 2020

2

Harald Fischer

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6 January 2020

author name string

Louise Dempster

3

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6 January 2020

Simon T Nevin

6

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6 January 2020

language of work or name

English

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publication date

14 September 2005

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6 January 2020

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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volume

102

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6 January 2020

issue

39

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6 January 2020

page(s)

13767-13772

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Ziconotide: neuronal calcium channel blocker for treating severe chronic pain

6 January 2020

cites work

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Squash inhibitors: from structural motifs to macrocyclic knottins

5 July 2018

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Drugs from the sea: conopeptides as potential therapeutics

5 July 2018

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Determinants of potency on alpha-conotoxin MII, a peptide antagonist of neuronal nicotinic receptors.

5 July 2018

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Conus venoms: a rich source of novel ion channel-targeted peptides

5 July 2018

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Twists, knots, and rings in proteins. Structural definition of the cyclotide framework

5 July 2018

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Converting a peptide into a drug: strategies to improve stability and bioavailability

5 July 2018

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Vulnerability of 125I-alpha-conotoxin MII binding sites to nigrostriatal damage in monkey.

5 July 2018

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alpha-Conotoxins: nicotinic acetylcholine receptor antagonists as pharmacological tools and potential drug leads

5 July 2018

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Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif

5 July 2018

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5 July 2018

The Protein Data Bank

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Native-state hydrogen-exchange studies of a fragment complex can provide structural information about the isolated fragments

5 July 2018

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Three-dimensional solution structure of alpha-conotoxin MII by NMR spectroscopy: effects of solution environment on helicity

5 July 2018

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Torsion angle dynamics for NMR structure calculation with the new program DYANA

5 July 2018

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Determinants of specificity for alpha-conotoxin MII on alpha3beta2 neuronal nicotinic receptors.

5 July 2018

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New applications of simulated annealing in X-ray crystallography and solution NMR.

5 July 2018

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AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR

5 July 2018

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PROMOTIF--a program to identify and analyze structural motifs in proteins

5 July 2018

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A new alpha-conotoxin which targets alpha3beta2 nicotinic acetylcholine receptors

5 July 2018

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Synthesis of proteins by native chemical ligation

5 July 2018

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1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects

5 July 2018

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Alpha-conotoxins PnIA and [A10L]PnIA stabilize different states of the alpha7-L247T nicotinic acetylcholine receptor.

5 July 2018

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https://api.crossref.org/works/10.1073%2FPNAS.0504613102

Development of novel antibacterial peptides that kill resistant isolates.

21 January 2018

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Characterization of the functional subunit combination of nicotinic acetylcholine receptors in bovine adrenal chromaffin cells

21 January 2018

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The structural aspects of limited proteolysis of native proteins

21 January 2018

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The effect of backbone cyclization on the thermodynamics of beta-sheet unfolding: stability optimization of the PIN WW domain

21 January 2018

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Three-dimensional solution structure of alpha-conotoxin MII, an alpha3beta2 neuronal nicotinic acetylcholine receptor-targeted ligand

21 January 2018

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12 December 2020

Single Amino Acid Substitutions in α-Conotoxin PnIA Shift Selectivity for Subtypes of the Mammalian Neuronal Nicotinic Acetylcholine Receptor

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12 December 2020

Peptide stability in drug development: a comparison of peptide reactivity in different biological media

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12 December 2020

In situ neutralization in Boc-chemistry solid phase peptide synthesis. Rapid, high yield assembly of difficult sequences

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12 December 2020

Peptide stability in drug development. II. Effect of single amino acid substitution and glycosylation on peptide reactivity in human serum

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12 December 2020

Botulinum A and the light chain of tetanus toxins inhibit distinct stages of Mg.ATP-dependent catecholamine exocytosis from permeabilised chromaffin cells

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Identifiers

DOI

10.1073/PNAS.0504613102

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6 January 2020

0 references

1 reference

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6 January 2020

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