TRAIL sensitize MDR cells to MDR-related drugs by down-regulation of P-glycoprotein through inhibition of DNA-PKcs/Akt/GSK-3beta pathway and activation of caspases (Q34053698)

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English	TRAIL sensitize MDR cells to MDR-related drugs by down-regulation of P-glycoprotein through inhibition of DNA-PKcs/Akt/GSK-3beta pathway and activation of caspases	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

TRAIL sensitize MDR cells to MDR-related drugs by down-regulation of P-glycoprotein through inhibition of DNA-PKcs/Akt/GSK-3beta pathway and activation of caspases (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

author name string

Suk-Bin Seo

1

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Jung-Gu Hur

2

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Mi-Ju Kim

3

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Jae-Won Lee

4

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Hak-Bong Kim

5

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Jae-Ho Bae

6

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Dong-Wan Kim

7

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Chi-Dug Kang

8

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Sun-Hee Kim

9

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

publication date

28 July 2010

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Europe PubMed Central

PubMed publication ID

30 July 2017

Molecular Cancer

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

199

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair.

1 reference

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Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: the therapeutic potential of Akt inhibition

1 reference

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1 reference

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Reversal of P-glycoprotein-mediated multi-drug resistance by the E3 ubiquitin ligase Cbl-b in human gastric adenocarcinoma cells

1 reference

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c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells

1 reference

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Perifosine synergistically enhances TRAIL-induced myeloma cell apoptosis via up-regulation of death receptors

1 reference

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Activation of beta-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells

1 reference

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Deregulation of the mitochondrial apoptotic machinery and development of molecular targeted drugs in acute myeloid leukemia.

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PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival

1 reference

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Apoptotic blocks and chemotherapy resistance: strategies to identify Bcl-2 protein signatures.

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Recent advances in P-glycoprotein-mediated multidrug resistance reversal mechanisms

1 reference

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Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NF kappa B pathway

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Phosphorylation of RNA helicase A by DNA-dependent protein kinase is indispensable for expression of the MDR1 gene product P-glycoprotein in multidrug-resistant human leukemia cells

1 reference

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ABC transporters and drug resistance in leukemia: was P-gp nothing but the first head of the Hydra?

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TRAIL signalling: decisions between life and death.

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The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways

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P-glycoprotein enhances TRAIL-triggered apoptosis in multidrug resistant cancer cells by interacting with the death receptor DR5.

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Caspase-dependent cleavage of 170-kDa P-glycoprotein during apoptosis of human T-lymphoblastoid CEM cells

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Targeting multidrug resistance in cancer

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Development of multidrug resistance due to multiple factors including P-glycoprotein overexpression under K-selection after MYC and HRAS oncogene activation

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Sensitization of multidrug resistant human ostesarcoma cells to Apo2 Ligand/TRAIL-induced apoptosis by inhibition of the Akt/PKB kinase.

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Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918570

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Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

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Proteolytic cleavage of the catalytic subunit of DNA-dependent protein kinase during poliovirus infection

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Upregulation of FLIP(S) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers

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Activation of the PI3K/Akt pathway and chemotherapeutic resistance

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c-Myc augments the apoptotic activity of cytosolic death receptor signaling proteins by engaging the mitochondrial apoptotic pathway

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Multidrug resistance in cancer: role of ATP-dependent transporters

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The role of c-myc in regulating mdr1 gene expression in tumor cell line KB.

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based on heuristic

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1186/1476-4598-9-199

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Europe PubMed Central

PubMed publication ID

30 July 2017

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PMC publication ID

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Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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