A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway (Q34055922)

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English	A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

30 July 2017

A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

1 reference

based on heuristic

inferred from title

allosteric inhibitor

1 reference

based on heuristic

inferred from title

Christian Le Gouill

7

object named as

Christian Le Gouill

0 references

William D. Lubell

object named as

William D Lubell

13

0 references

object named as

Michel Bouvier

10

0 references

Sylvain Chemtob

12

object named as

Sylvain Chemtob

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Christiane Quiniou

4

object named as

Christiane Quiniou

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

author name string

Eugénie Goupil

1

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Danaë Tassy

2

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Europe PubMed Central

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30 July 2017

Carine Bourguet

3

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Europe PubMed Central

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30 July 2017

Veronica Wisehart

5

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Europe PubMed Central

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30 July 2017

Darlaine Pétrin

6

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Europe PubMed Central

PubMed publication ID

30 July 2017

Christian Le Gouill

7

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Dominic Devost

8

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Hans H Zingg

9

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Europe PubMed Central

PubMed publication ID

30 July 2017

Horacio Uri Saragovi

11

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Europe PubMed Central

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30 July 2017

Audrey Claing

14

1 reference

Europe PubMed Central

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30 July 2017

Terence E Hébert

15

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30 July 2017

Stéphane A Laporte

16

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30 July 2017

language of work or name

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publication date

15 June 2010

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Europe PubMed Central

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30 July 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

30 July 2017

285

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Europe PubMed Central

PubMed publication ID

30 July 2017

33

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Europe PubMed Central

PubMed publication ID

30 July 2017

25624-25636

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

1 reference

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28 July 2018

Orthosteric/allosteric bitopic ligands: going hybrid at GPCRs.

1 reference

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Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation.

1 reference

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28 July 2018

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

1 reference

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28 July 2018

Functional selectivity through protean and biased agonism: who steers the ship?

1 reference

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The evasive nature of drug efficacy: implications for drug discovery

1 reference

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Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: a perspective.

1 reference

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An acquired hypocalciuric hypercalcemia autoantibody induces allosteric transition among active human Ca-sensing receptor conformations.

1 reference

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A novel, conformation-specific allosteric inhibitor of the tachykinin NK2 receptor (NK2R) with functionally selective properties

1 reference

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28 July 2018

Prostaglandin F2alpha and its receptor as activators of human decidua

1 reference

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Novel in vitro system for functional assessment of oxytocin action

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Dual signaling is differentially activated by different active states of the metabotropic glutamate receptor 1alpha

1 reference

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Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity

1 reference

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28 July 2018

Rho GTPases: biochemistry and biology

1 reference

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28 July 2018

Localized RhoA activation as a requirement for the induction of membrane ruffling

1 reference

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Design, synthesis, and application of azabicyclo[X.Y.0]alkanone amino acids as constrained dipeptide surrogates and peptide mimics

1 reference

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28 July 2018

Essential role for the second extracellular loop in C5a receptor activation

1 reference

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G-protein-coupled receptor allosterism: the promise and the problem(s).

1 reference

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The second extracellular loop of the dopamine D2 receptor lines the binding-site crevice

1 reference

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28 July 2018

The role of prostaglandins in the initiation of parturition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Myometrial activation and preterm labour: evidence supporting a role for the prostaglandin F receptor--a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

THG113: a novel selective FP antagonist that delays preterm labor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

G protein-coupled receptor allosterism and complexing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Oxytocin antagonists: clinical and scientific considerations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Induction of c-fos and c-jun messenger ribonucleic acid expression by prostaglandin F2alpha is mediated by a protein kinase C-dependent extracellular signal-regulated kinase mitogen-activated protein kinase pathway in bovine luteal cells

1 reference

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28 July 2018

Activation of FP prostanoid receptor isoforms leads to Rho-mediated changes in cell morphology and in the cell cytoskeleton

1 reference

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Subtype-selective positive cooperative interactions between brucine analogs and acetylcholine at muscarinic receptors: functional studies

1 reference

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28 July 2018

Failure of parturition in mice lacking the prostaglandin F receptor

1 reference

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28 July 2018

Cloning of a carboxyl-terminal isoform of the prostanoid FP receptor

1 reference

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Two-point kinetic experiments to quantify allosteric effects on radioligand dissociation

1 reference

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28 July 2018

Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase

1 reference

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G alpha 12 and G alpha 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly

1 reference

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28 July 2018

Rho as a regulator of the cytoskeleton.

1 reference

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28 July 2018

Prostaglandin F2 alpha stimulates phosphatidylinositol 4,5-bisphosphate hydrolysis and mobilizes intracellular Ca2+ in bovine luteal cells

1 reference

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Allosteric modulators of g protein-coupled receptors: future therapeutics for complex physiological disorders.

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RHO protein regulation of contraction in the human uterus

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Analysis of the spatiotemporal activation of rho GTPases using Raichu probes.

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Tocolytic effect of a Rho-kinase inhibitor in a mouse model of lipopolysaccharide-induced preterm delivery

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Allosteric regulation of muscarinic receptors.

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Prostaglandin F2 alpha receptor is coupled to Gq in cDNA-transfected Chinese hamster ovary cells

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Role of mitogen-activated protein kinase pathway in prostaglandin F2alpha-induced rat puerperal uterine contraction

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Intracellular mechanisms underlying prostaglandin F2alpha-stimulated phasic myometrial contractions

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12 December 2020

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Angiotensin II activates RhoA in cardiac myocytes: a critical role of RhoA in angiotensin II-induced premyofibril formation

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Female reproduction in mice lacking the prostaglandin F receptor. Roles of prostaglandin and oxytocin receptors in parturition

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Identifiers

10.1074/JBC.M110.115196

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

ResearchGate publication ID

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