R1507, an anti-insulin-like growth factor-1 receptor (IGF-1R) antibody, and EWS/FLI-1 siRNA in Ewing's sarcoma: convergence at the IGF/IGFR/Akt axis (Q34055933)

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English	R1507, an anti-insulin-like growth factor-1 receptor (IGF-1R) antibody, and EWS/FLI-1 siRNA in Ewing's sarcoma: convergence at the IGF/IGFR/Akt axis	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

30 July 2017

R1507, an anti-insulin-like growth factor-1 receptor (IGF-1R) antibody, and EWS/FLI-1 siRNA in Ewing's sarcoma: convergence at the IGF/IGFR/Akt axis (English)

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Europe PubMed Central

PubMed publication ID

30 July 2017

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inferred from title

Razelle Kurzrock

8

object named as

Razelle Kurzrock

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30 July 2017

author name string

Helen J Huang

1

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Europe PubMed Central

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30 July 2017

Laura S Angelo

2

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30 July 2017

Jordi Rodon

3

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Europe PubMed Central

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30 July 2017

Michael Sun

4

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30 July 2017

Klaus-Peter Kuenkele

5

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30 July 2017

Henrique A Parsons

6

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30 July 2017

Jonathan C Trent

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30 July 2017

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publication date

11 October 2011

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Europe PubMed Central

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30 July 2017

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30 July 2017

6

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30 July 2017

10

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Europe PubMed Central

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30 July 2017

e26060

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Europe PubMed Central

PubMed publication ID

30 July 2017

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Creative Commons Attribution 4.0 International

11 October 2011

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April 2022 Public Data File from Crossref

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Efficacy of ganitumab (AMG 479), alone and in combination with rapamycin, in Ewing's and osteogenic sarcoma models

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Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer

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Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): rationale for cotargeting IGF-1R and IR in cancer

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28 July 2018

Biological rationale and current clinical experience with anti-insulin-like growth factor 1 receptor monoclonal antibodies in treating sarcoma: twenty years from the bench to the bedside

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28 July 2018

Current treatment protocols have eliminated the prognostic advantage of type 1 fusions in Ewing sarcoma: a report from the Children's Oncology Group

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Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study

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28 July 2018

Autocrine IGF-1/IGF-1R signaling is responsible for constitutive PI3K/Akt activation in acute myeloid leukemia: therapeutic value of neutralizing anti-IGF-1R antibody

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28 July 2018

Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1.

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A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma

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28 July 2018

Stable interference of EWS-FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target

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28 July 2018

The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors

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28 July 2018

Molecular abnormalities in Ewing's sarcoma

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28 July 2018

Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody

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Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: lessons from the first clinical trials

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28 July 2018

IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.

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28 July 2018

Mechanisms of resistance to ErbB-targeted cancer therapeutics

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Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins

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28 July 2018

Selective inhibition of SCLC growth by the A12 anti-IGF-1R monoclonal antibody correlates with inhibition of Akt.

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28 July 2018

Analysis of genes critical for growth regulation identifies Insulin-like Growth Factor 2 Receptor variations with possible functional significance as risk factors for osteosarcoma

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28 July 2018

EWS/FLI-1 oncoprotein subtypes impose different requirements for transformation and metastatic activity in a murine model

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28 July 2018

Comparative analysis of routine histology, immunohistochemistry, reverse transcriptase polymerase chain reaction, and fluorescence in situ hybridization in diagnosis of Ewing family of tumors

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28 July 2018

Combined transcriptional and translational targeting of EWS/FLI-1 in Ewing's sarcoma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191161

28 July 2018

The role of the IGF system in cancer growth and metastasis: overview and recent insights

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28 July 2018

Ewing's sarcoma family of tumors: current management

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28 July 2018

Loss of heterozygosity of M6P/IGF2R gene is an early event in the development of prostate cancer.

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28 July 2018

EWS-ETS oncoproteins: the linchpins of Ewing tumors

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28 July 2018

Molecular diagnosis of Ewing's sarcoma/primitive neuroectodermal tumor in formalin-fixed paraffin-embedded tissues by RT-PCR and fluorescence in situ hybridization

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28 July 2018

The role of insulin-like growth factor 2 and its receptors in human tumors

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28 July 2018

M6P/IGF2R loss of heterozygosity in head and neck cancer associated with poor patient prognosis

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28 July 2018

Establishment and characterization of a schwannoma cell line from a patient with neurofibromatosis 2.

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Visceral primitive peripheral neuroectodermal tumors: a clinicopathologic and molecular study

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28 July 2018

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.

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28 July 2018

A phase I study of weekly R1507, a human monoclonal antibody insulin-like growth factor-I receptor antagonist, in patients with advanced solid tumors.

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EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3.

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Impact of EWS-ETS fusion type on disease progression in Ewing's sarcoma/peripheral primitive neuroectodermal tumor: prospective results from the cooperative Euro-E.W.I.N.G. 99 trial.

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M6P/IGF2R is mutated in squamous cell carcinoma of the lung

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Gastric cancer: the role of insulin‐like growth factor 2 (IGF 2) and its receptors (IGF 1R and M6‐P/IGF 2R)

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The 3' UTR IGF2R-A2/B2 variant is associated with increased tumor growth and advanced stages in non-small cell lung cancer

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IGF2: epigenetic regulation and role in development and disease

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Rapid apoptosis induction by IGFBP-3 involves an insulin-like growth factor-independent nucleomitochondrial translocation of RXRalpha/Nur77.

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R1507, a fully human monoclonal antibody targeting IGF-1R, is effective alone and in combination with rapamycin in inhibiting growth of osteosarcoma xenografts

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Adenovirus 5 early region 1A does not induce expression of the ewing sarcoma fusion product EWS-FLI1 in breast and ovarian cancer cell lines

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Type 1 (11;22)(q24:q12) translocation is common in Ewing's sarcoma/peripheral neuroectodermal tumour in south Indian patients

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12 December 2020

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10.1371/JOURNAL.PONE.0026060

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Europe PubMed Central

PubMed publication ID

30 July 2017

2011PLoSO...626060H

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PMC publication ID

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Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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