Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2. (Q34059266)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20615966%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

title

Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2 (English)

1 reference

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7 February 2020

author

Massimiliano Agostini

7

1 reference

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7 February 2020

author name string

Berna S Sayan

1

1 reference

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7 February 2020

Ai Li Yang

2

1 reference

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7 February 2020

Franco Conforti

3

1 reference

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7 February 2020

Paola Tucci

4

1 reference

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7 February 2020

Maria Cristina Piro

5

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7 February 2020

Gareth J Browne

6

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7 February 2020

Sergio Bernardini

8

1 reference

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7 February 2020

Richard A Knight

9

1 reference

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7 February 2020

Tak W Mak

10

1 reference

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7 February 2020

Gerry Melino

11

1 reference

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7 February 2020

language of work or name

English

0 references

publication date

6 July 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20615966%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

7 February 2020

number of pages

6

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

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7 February 2020

volume

107

1 reference

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7 February 2020

issue

29

1 reference

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7 February 2020

page(s)

12877-12882

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20615966%20AND%20SRC:MED&resulttype=core&format=json

The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73

7 February 2020

cites work

1 reference

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P73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis

5 July 2018

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The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch

5 July 2018

1 reference

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Cleavage of the transactivation-inhibitory domain of p63 by caspases enhances apoptosis

5 July 2018

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p53 is cleaved by caspases generating fragments localizing to mitochondria

5 July 2018

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The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis

5 July 2018

1 reference

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TAp73/Delta Np73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma.

5 July 2018

1 reference

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New antibodies recognizing p73: comparison with commercial antibodies.

5 July 2018

1 reference

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A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73

5 July 2018

1 reference

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The ubiquitin-protein ligase Itch regulates p73 stability

5 July 2018

1 reference

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Ubiquitin-dependent degradation of p73 is inhibited by PML.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919933

Pin1 links the activities of c-Abl and p300 in regulating p73 function.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919933

DNA damage induces the rapid and selective degradation of the DeltaNp73 isoform, allowing apoptosis to occur

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919933

Functional regulation of p73 and p63: development and cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919933

p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919933

p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919933

DeltaNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919933

p73: Friend or foe in tumorigenesis

5 July 2018

1 reference

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p53 induces the expression of its antagonist p73 Delta N, establishing an autoregulatory feedback loop

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919933

DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest.

5 July 2018

1 reference

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Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter

5 July 2018

1 reference

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Possible oncogenic potential of DeltaNp73: a newly identified isoform of human p73

5 July 2018

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NAPO as a novel marker for apoptosis

5 July 2018

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An anti-apoptotic role for the p53 family member, p73, during developmental neuron death

5 July 2018

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The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

5 July 2018

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5 July 2018

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Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

5 July 2018

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Transactivation-deficient Delta TA-p73 inhibits p53 by direct competition for DNA binding: implications for tumorigenesis.

5 July 2018

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p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis

21 January 2018

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Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53.

21 January 2018

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DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes.

21 January 2018

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Acquired expression of transcriptionally active p73 in hepatocellular carcinoma cells

21 January 2018

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Increased DeltaN-p73 expression in tumors by upregulation of the E2F1-regulated, TA-promoter-derived DeltaN'-p73 transcript

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20615966

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12 December 2020

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Identifiers

DOI

10.1073/PNAS.0911828107

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20615966%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

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mapped directly with Wikidata item

24 November 2022

based on heuristic

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7 February 2020

PubMed publication ID

20615966

1 reference