Induction of drug metabolism by nuclear receptor CAR: molecular mechanisms and implications for drug research (Q34060795)

30 July 2017

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title

Induction of drug metabolism by nuclear receptor CAR: molecular mechanisms and implications for drug research (English)

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30 July 2017

Masahiko N

1

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30 July 2017

Honkakoski P

series ordinal

2

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30 July 2017

language of work or name

English

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publication date

1 October 2000

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European Journal of Pharmaceutical Sciences

30 July 2017

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30 July 2017

11

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30 July 2017

4

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30 July 2017

259-264

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Ligand-dependent regulation of plasmid-based transgene expression in vivo

30 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Phenobarbital induction of CYP2B1/2 in primary hepatocytes: endocrine regulation and evidence for a single pathway for multiple inducers

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Mechanism of action of the nongenotoxic peroxisome proliferators: role of the peroxisome proliferator-activator receptor alpha.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Olfaction in humans with special reference to odorous 16-androstenes: their occurrence, perception and possible social, psychological and sexual impact

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene.

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Regulatory DNA elements of phenobarbital-responsive cytochrome P450 CYP2B genes

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Regulation of cytochrome P450 (CYP) genes by nuclear receptors.

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Role of the peroxisome proliferator-activated receptor in cytochrome P450 4A gene regulation.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

The peroxisome proliferator response element of the gene encoding the peroxisomal beta-oxidation enzyme enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase is a target for constitutive androstane receptor beta/9-cis-retinoic acid receptor-mediated t

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

The RXR heterodimers and orphan receptors

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

NF-kappaB is involved in the induction of the rat hepatic alpha1-acid glycoprotein gene by phenobarbital

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Molecular mechanisms of genetic polymorphisms of drug metabolism

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Proposed role of drug-metabolizing enzymes: regulation of steady state levels of the ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Ecdysone-inducible gene expression in mammalian cells and transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Enzyme induction in the cytochrome P-450 system

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Phenobarbital induction mediated by a distal CYP2B2 sequence in rat liver transiently transfected in situ

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Phenobarbital induction of AP-1 binding activity mediates activation of glutathione S-transferase and quinone reductase gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Phenobarbital responsiveness conferred by the 5'-flanking region of the rat CYP2B2 gene in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

In vitro and in vivo drug interactions involving human CYP3A.

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Localization of a phenobarbital-responsive element (PBRE) in the 5'-flanking region of the rat CYP2B2 gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Phenobarbital induction of cytochrome P-450 gene expression

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900112-3

7 January 2021

10.1016/S0928-0987(00)00112-3

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DOI

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release_kzqgjx567nf5xlfjt2xqnd6gwe

30 July 2017

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24 November 2022

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