Genistein, a natural product from soy, is a potent inhibitor of transthyretin amyloidosis (Q34078348)

30 July 2017

Genistein, a natural product from soy, is a potent inhibitor of transthyretin amyloidosis (English)

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transthyretin amyloidosis

30 July 2017

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3

Jeffery W Kelly

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30 July 2017

Nora S Green

1

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PubMed ID

16195386

30 July 2017

Ted R Foss

series ordinal

2

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PubMed ID

16195386

30 July 2017

language of work or name

English

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publication date

29 September 2005

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30 July 2017

6

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Proceedings of the National Academy of Sciences of the United States of America

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published in

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30 July 2017

102

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30 July 2017

14545-14550

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30 July 2017

41

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Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation

30 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Anticancer therapeutic potential of soy isoflavone, genistein.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Prevention of transthyretin amyloid disease by changing protein misfolding energetics.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Mechanisms of cancer chemoprevention by soy isoflavone genistein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

A repeated 28-day oral dose toxicity study of genistein in rats, based on the 'Enhanced OECD Test Guideline 407' for screening endocrine-disrupting chemicals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Therapeutic strategies for human amyloid diseases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Absorption and metabolism of flavonoids in the caco-2 cell culture model and a perused rat intestinal model

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Trans-suppression of misfolding in an amyloid disease.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Transthyretin slowly exchanges subunits under physiological conditions: A convenient chromatographic method to study subunit exchange in oligomeric proteins.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Transthyretin related familial amyloid polyneuropathy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Deuterium-proton exchange on the native wild-type transthyretin tetramer identifies the stable core of the individual subunits and indicates mobility at the subunit interface

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Biological properties of genistein. A review of in vitro and in vivo data

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Rational design of potent human transthyretin amyloid disease inhibitors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

The most pathogenic transthyretin variant, L55P, forms amyloid fibrils under acidic conditions and protofilaments under physiological conditions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Inhibiting transthyretin conformational changes that lead to amyloid fibril formation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

A review of the amyloidoses that infiltrate the heart.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Transthyretin quaternary and tertiary structural changes facilitate misassembly into amyloid.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Variant-sequence transthyretin (isoleucine 122) in late-onset cardiac amyloidosis in black Americans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Tofu and risk of breast cancer in Asian-Americans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Thyroid hormone transport proteins.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Clinical improvement and amyloid regression after liver transplantation in hereditary transthyretin amyloidosis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Nonsteroidal estrogens of dietary origin: possible roles in hormone-dependent disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Biochemical marker in familial amyloidotic polyneuropathy, Portuguese type. Family studies on the transthyretin (prealbumin)-methionine-30 variant

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Fibril in senile systemic amyloidosis is derived from normal transthyretin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Dietary effects on breast-cancer risk in Singapore

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Dietary fiber, phytoestrogens, and breast cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Studies on thyroid hormone-binding proteins. II. Binding of thyroid hormones, retinol-binding protein, and fluorescent probes to prealbumin and effects of thyroxine on prealbumin subunit self association

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Structure of prealbumin: secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 A

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253540

Quantification of genistein and genistin in soybeans and soybean products.

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0501609102

Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0501609102

Long-term follow-up of survival of liver transplant recipients with familial amyloid polyneuropathy (Portuguese type)

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0501609102

Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0501609102

Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0501609102

Kinetic stabilization of an oligomeric protein by a single ligand binding event

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0501609102

Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0501609102

Kinetic stabilization of an oligomeric protein under physiological conditions demonstrated by a lack of subunit exchange: implications for transthyretin amyloidosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0501609102

Transthyretin aggregation under partially denaturing conditions is a downhill polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0501609102

Native state stabilization by NSAIDs inhibits transthyretin amyloidogenesis from the most common familial disease variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0501609102

The Tetrameric Protein Transthyretin Dissociates to a Non-native Monomer in Solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0501609102

The amyloidogenic potential of transthyretin variants correlates with their tendency to aggregate in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0501609102

Cardiac amyloid in patients with familial amyloid polyneuropathy consists of abundant wild-type transthyretin

21 January 2018

1 reference

12 December 2020

Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements

1 reference

12 December 2020

Clinical characteristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy men

1 reference

12 December 2020

Safety and pharmacokinetics of purified soy isoflavones: single-dose administration to postmenopausal women

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12 December 2020

An X-ray study of the subunit structure of prealbumin

1 reference

12 December 2020

Effect of dietary genistein on antioxidant enzyme activities in SENCAR mice

1 reference

12 December 2020

Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro

1 reference

12 December 2020

Progression of ventricular wall thickening after liver transplantation for familial amyloidosis

1 reference

12 December 2020

Discovering transthyretin amyloid fibril inhibitors by limited screening

1 reference

12 December 2020

Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0501609102

1 reference

30 July 2017

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1 reference

30 July 2017

1 reference

PubMed ID

16195386