Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes (Q34078522)

30 July 2017

title

Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes (English)

1 reference

30 July 2017

Laura E Edgington

1

0 references

Martijn Verdoes

object named as

Martijn Verdoes

series ordinal

2

0 references

Matthew Bogyo

series ordinal

3

object named as

Matthew Bogyo

1 reference

30 July 2017

publication date

16 November 2011

1 reference

Current Opinion in Chemical Biology

30 July 2017

published in

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30 July 2017

volume

15

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30 July 2017

issue

6

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30 July 2017

page(s)

798-805

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Identification of a myeloid-derived suppressor cell cystatin-like protein that inhibits metastasis

30 July 2017

cites work

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Comparative assessment of substrates and activity based probes as tools for non-invasive optical imaging of cysteine protease activity

5 July 2018

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Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors.

5 July 2018

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Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes

5 July 2018

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Single-cell imaging of retinal ganglion cell apoptosis with a cell-penetrating, activatable peptide probe in an in vivo glaucoma model

5 July 2018

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VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation

5 July 2018

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Molecular imaging of innate immune cell function in transplant rejection

5 July 2018

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Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation

5 July 2018

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An improved cell-penetrating, caspase-activatable, near-infrared fluorescent peptide for apoptosis imaging

5 July 2018

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Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation

5 July 2018

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Non-invasive optical detection of cathepsin K-mediated fluorescence reveals osteoclast activity in vitro and in vivo.

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Comparison of activated caspase detection methods in the gentamicin-treated chick cochlea

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Activity-based protein profiling: from enzyme chemistry to proteomic chemistry

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Selective activity-based probes for cysteine cathepsins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Use of a fluorescently labeled poly-caspase inhibitor for in vivo detection of apoptosis related to vascular-targeting agent arsenic trioxide for cancer therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

All that glitters is not gold: all that FLICA binds is not caspase. A caution in data interpretation--and new opportunities

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Combinatorial strategies for targeting protein families: application to the proteases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Lysosomal cysteine cathepsins: signaling pathways in apoptosis

5 July 2018

1 reference

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Substrate activity screening (SAS): a general procedure for the preparation and screening of a fragment-based non-peptidic protease substrate library for inhibitor discovery

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Biochemical and in vivo characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis

5 July 2018

1 reference

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Cysteine cathepsins and the cutting edge of cancer invasion

5 July 2018

1 reference

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Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease.

5 July 2018

1 reference

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Development of calpain-specific inactivators by screening of positional scanning epoxide libraries

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Tagging and detection strategies for activity-based proteomics.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Caspase function in programmed cell death

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Dynamic imaging of protease activity with fluorescently quenched activity-based probes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Activity-based probes that target diverse cysteine protease families

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Substrate activity screening: a fragment-based method for the rapid identification of nonpeptidic protease inhibitors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Developing a peptide-based near-infrared molecular probe for protease sensing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Apoptotic cell death kinetics in vitro depend on the cell types and the inducers used

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Interactions of fluorochrome-labeled caspase inhibitors with apoptotic cells: a caution in data interpretation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Activation of caspases measured in situ by binding of fluorochrome-labeled inhibitors of caspases (FLICA): correlation with DNA fragmentation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Determination of caspase specificities using a peptide combinatorial library

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Fluorogenic substrates as detectors of caspase activity during natural killer cell-induced apoptosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Liver apoptosis following normothermic ischemia-reperfusion: in vivo evaluation of caspase activity by FLIVO assay in rats.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Synthesis and characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237724

Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammation

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22098719

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Commonly used caspase inhibitors designed based on substrate specificity profiles lack selectivity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22098719

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Optical Visualization of Cathepsin K Activity in Atherosclerosis With a Novel, Protease-Activatable Fluorescence Sensor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22098719

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CBPA.2011.10.012

1 reference

30 July 2017

1 reference

30 July 2017

1 reference