Effect of chemical modifications on modulation of gene expression by duplex antigene RNAs that are complementary to non-coding transcripts at gene promoters (Q34080079)

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English	Effect of chemical modifications on modulation of gene expression by duplex antigene RNAs that are complementary to non-coding transcripts at gene promoters	scientific article

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scholarly article

1 reference

Europe PubMed Central

30 July 2017

Effect of chemical modifications on modulation of gene expression by duplex antigene RNAs that are complementary to non-coding transcripts at gene promoters (English)

1 reference

Europe PubMed Central

30 July 2017

author name string

Jonathan K Watts

1

1 reference

Europe PubMed Central

30 July 2017

Dongbo Yu

2

1 reference

Europe PubMed Central

30 July 2017

Klaus Charisse

3

1 reference

Europe PubMed Central

30 July 2017

Christophe Montaillier

4

1 reference

Europe PubMed Central

30 July 2017

Pierre Potier

5

1 reference

Europe PubMed Central

30 July 2017

Muthiah Manoharan

6

1 reference

Europe PubMed Central

30 July 2017

David R Corey

7

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Europe PubMed Central

30 July 2017

language of work or name

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publication date

19 April 2010

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Europe PubMed Central

30 July 2017

Nucleic Acids Research

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Europe PubMed Central

30 July 2017

38

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Europe PubMed Central

30 July 2017

15

1 reference

Europe PubMed Central

30 July 2017

5242-5259

1 reference

Europe PubMed Central

30 July 2017

copyright license

Creative Commons Attribution-NonCommercial 2.5 Generic

7 November 2016

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April 2022 Public Data File from Crossref

copyright status

0 references

RNA-directed transcriptional gene silencing and activation in human cells

1 reference

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5 July 2018

siRNA and innate immunity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Bidirectional transcription directs both transcriptional gene activation and suppression in human cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Chemical modification patterns compatible with high potency dicer-substrate small interfering RNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Chemically modified siRNA: tools and applications.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Antisense transcripts are targets for activating small RNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Determinants of cytokine induction by small interfering RNA in human peripheral blood mononuclear cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

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Overcoming the innate immune response to small interfering RNA.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Chemical modification: the key to clinical application of RNA interference?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Improved silencing properties using small internally segmented interfering RNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Promoter-associated RNA is required for RNA-directed transcriptional gene silencing in human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Interfering with disease: a progress report on siRNA-based therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Inhibiting gene expression with peptide nucleic acid (PNA)--peptide conjugates that target chromosomal DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Inhibiting gene expression with locked nucleic acids (LNAs) that target chromosomal DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Activating gene expression in mammalian cells with promoter-targeted duplex RNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Small dsRNAs induce transcriptional activation in human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

5'-Triphosphate RNA is the ligand for RIG-I

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Competition for RISC binding predicts in vitro potency of siRNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Involvement of AGO1 and AGO2 in mammalian transcriptional silencing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Cleavage of the siRNA passenger strand during RISC assembly in human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Inhibiting gene expression at transcription start sites in chromosomal DNA with antigene RNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

RNA interference and chemically modified small interfering RNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Small interfering RNA-induced transcriptional gene silencing in human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

In vivo activity of nuclease-resistant siRNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

siRNA function in RNAi: a chemical modification analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Similar behaviour of single-strand and double-strand siRNAs suggests they act through a common RNAi pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

LNA: a versatile tool for therapeutics and genomics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Tolerance for mutations and chemical modifications in a siRNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Accessibility of nuclear DNA to triplex-forming oligonucleotides: the integrated HIV-1 provirus as a target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Transcription-mediated binding of peptide nucleic acid (PNA) to double-stranded DNA: sequence-specific suicide transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

5 July 2018

Fully 2'-deoxy-2'-fluoro substituted nucleic acids induce RNA interference in mammalian cell culture.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

28 October 2018

Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

28 October 2018

Improving RNA interference in mammalian cells by 4'-thio-modified small interfering RNA (siRNA): effect on siRNA activity and nuclease stability when used in combination with 2'-O-alkyl modifications.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

28 October 2018

Inhibiting transcription of chromosomal DNA with antigene peptide nucleic acids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

28 October 2018

Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo

1 reference

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28 October 2018

Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

28 October 2018

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

28 October 2018

RNA interference in mammalian cells by chemically-modified RNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

28 October 2018

RNAi in human cells: basic structural and functional features of small interfering RNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2926613

28 October 2018

Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways.

1 reference

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Functional anatomy of a dsRNA trigger: differential requirement for the two trigger strands in RNA interference

1 reference

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Gene Expression Analysis in Blood Cells in Response to Unmodified and 2′-Modified siRNAs Reveals TLR-dependent and Independent Effects

1 reference

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28 October 2018

Progesterone receptor plays a major antiinflammatory role in human myometrial cells by antagonism of nuclear factor-kappaB activation of cyclooxygenase 2 expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/20403811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Silencing gene expression by targeting chromosomal DNA with antigene peptide nucleic acids and duplex RNAs

1 reference

https://pubmed.ncbi.nlm.nih.gov/20403811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2'-O-methyl-modified RNAs act as TLR7 antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/20403811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/NAR/GKQ258

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

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