Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. (Q34082498)

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9 November 2019

title

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice (English)

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9 November 2019

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5

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9 November 2019

Catriona A. McLean

6

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9 November 2019

Robert D. Moir

13

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9 November 2019

Ashley I. Bush

19

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9 November 2019

author name string

R A Cherny

1

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9 November 2019

C S Atwood

2

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9 November 2019

M E Xilinas

3

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9 November 2019

D N Gray

4

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9 November 2019

K J Barnham

7

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9 November 2019

I Volitakis

8

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9 November 2019

F W Fraser

9

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9 November 2019

Y Kim

10

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9 November 2019

X Huang

11

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9 November 2019

L E Goldstein

12

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9 November 2019

J T Lim

14

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K Beyreuther

15

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9 November 2019

H Zheng

16

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9 November 2019

R E Tanzi

17

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9 November 2019

C L Masters

18

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9 November 2019

language of work or name

English

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publication date

1 June 2001

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9 November 2019

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9 November 2019

volume

30

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9 November 2019

page(s)

665-676

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9 November 2019

issue

3

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Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

9 November 2019

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Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

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Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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7 January 2021

Neurotoxicity of halogenated hydroxyquinolines: clinical analysis of cases reported outside Japan

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Rapid induction of Alzheimer A beta amyloid formation by zinc.

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Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc

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Modified amyloid beta protein ending at 42 or 40 with different solubility accumulates in the brain of Alzheimer's disease

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Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.

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The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

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7 January 2021

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

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Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay.

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7 January 2021

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

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7 January 2021

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

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7 January 2021

Intestinal absorption and metabolism of clioquinol in the rat

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7 January 2021

Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains.

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7 January 2021

Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains

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7 January 2021

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

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Copper, iron and zinc in Alzheimer's disease senile plaques.

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Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

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7 January 2021

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

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7 January 2021

Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations.

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7 January 2021

Relation between subacute myelo-optic neuropathy (S.M.O.N.) and clioquinol: nationwide survey

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7 January 2021

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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7 January 2021

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

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7 January 2021

Inhibition of Alzheimer's amyloidosis by peptides that prevent beta-sheet conformation

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7 January 2021

Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains

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7 January 2021

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7 January 2021

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7 January 2021

The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging.

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7 January 2021

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

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7 January 2021

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7 January 2021

Changes in uptake of vitamin B(12) and trace metals in brains of mice treated with clioquinol

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Identifiers

DOI

1 reference

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9 November 2019

1 reference