Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse. (Q34082587)

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English	Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse.	scientific article

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5 January 2020

Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse (English)

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5 January 2020

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pharmacokinetics

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Robert J. Lipinski

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Paul R Hutson

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Paul W Hannam

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Robert J Nydza

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Ida M Washington

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Gary G Girdaukas

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5 January 2020

Richard E Peterson

8

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Wade Bushman

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publication date

14 April 2008

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5 January 2020

Toxicological Sciences

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104

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1

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189-197

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5 January 2020

Mouse genetic models of cleft lip with or without cleft palate

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Identification and characterization of several dietary alkaloids as weak inhibitors of hedgehog signaling.

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Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers

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Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration

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Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion

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5 July 2018

Sonic hedgehog pathway inhibition alters epididymal function as assessed by the development of sperm motility

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In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice.

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Sonic hedgehog controls stem cell behavior in the postnatal and adult brain

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Hedgehog signalling in prostate regeneration, neoplasia and metastasis

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5 July 2018

Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes.

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Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

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Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

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Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

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5 July 2018

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

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5 July 2018

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

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5 July 2018

Patched acts catalytically to suppress the activity of Smoothened

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5 July 2018

Gene/environment causes of cleft lip and/or palate

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5 July 2018

Teratogenesis of holoprosencephaly

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Hedgehog signaling in animal development: paradigms and principles

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Sonic hedgehog regulates gastric gland morphogenesis in man and mouse.

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The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction.

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Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

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Expression of Veratrum alkaloid teratogenicity in the mouse.

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Recent advances in primary palate and midface morphogenesis research

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5 July 2018

Teratogenic Effects of Cyclopamine and Jervine in Rats, Mice and Hamsters

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Newborn and adult face shapes related to mouse cleft lip predisposition

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Medulloblastoma growth inhibition by hedgehog pathway blockade

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Sequential developmental changes in holoprosencephalic mouse embryos exposed to ethanol during the gastrulation period.

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Molecular interactions coordinating the development of the forebrain and face.

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Developmental alterations associated with spontaneous cleft lip and palate in CL/Fr mice.

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Craniofacial anomalies of the cultured mouse embryo induced by inhibition of sonic hedgehog signaling: an animal model of holoprosencephaly

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Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.

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Teratogenic compounds ofVeratrum californicum (Durand). X. Cyclopia in rabbits produced by cyclopamine

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The effect of dam strain on the craniofacial morphogenesis of CL/Fr mouse fetuses

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Identifiers

10.1093/TOXSCI/KFN076

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5 January 2020

1 reference

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5 January 2020

1 reference

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5 January 2020

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