Intensive glycaemic control for patients with type 2 diabetes: systematic review with meta-analysis and trial sequential analysis of randomised clinical trials (Q34083400)

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English	Intensive glycaemic control for patients with type 2 diabetes: systematic review with meta-analysis and trial sequential analysis of randomised clinical trials	scientific article

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scholarly article

1 reference

Europe PubMed Central

30 July 2017

7 references

13 March 2019

14 March 2019

24 March 2019

17 June 2019

18 November 2019

4 February 2021

19 July 2022

0 references

Intensive glycaemic control for patients with type 2 diabetes: systematic review with meta-analysis and trial sequential analysis of randomised clinical trials (English)

1 reference

Europe PubMed Central

30 July 2017

type 2 diabetes

2 references

18 November 2019

4 February 2021

0 references

0 references

cardiovascular disease

5 references

13 March 2019

14 March 2019

24 March 2019

17 June 2019

18 November 2019

diabetic angiopathy

5 references

13 March 2019

14 March 2019

24 March 2019

17 June 2019

18 November 2019

1 reference

18 November 2019

systematic review

1 reference

based on heuristic

inferred from title

Jørn Wetterslev

7

1 reference

Europe PubMed Central

30 July 2017

Christian Gluud

object named as

Christian Gluud

3

0 references

Bianca Hemmingsen

1

object named as

Bianca Hemmingsen

1 reference

Europe PubMed Central

30 July 2017

5

object named as

Thomas Almdal

1 reference

Europe PubMed Central

30 July 2017

Christina Hemmingsen

6

object named as

Christina Hemmingsen

1 reference

Europe PubMed Central

30 July 2017

author name string

Søren S Lund

2

1 reference

Europe PubMed Central

30 July 2017

Allan Vaag

4

1 reference

Europe PubMed Central

30 July 2017

language of work or name

0 references

publication date

24 November 2011

8 references

Europe PubMed Central

30 July 2017

13 March 2019

14 March 2019

24 March 2019

17 June 2019

18 November 2019

4 February 2021

19 July 2022

8 references

Europe PubMed Central

30 July 2017

13 March 2019

14 March 2019

24 March 2019

17 June 2019

18 November 2019

4 February 2021

19 July 2022

343

1 reference

Europe PubMed Central

30 July 2017

d6898

1 reference

Europe PubMed Central

30 July 2017

copyright license

Creative Commons Attribution-NonCommercial

7 references

13 March 2019

14 March 2019

24 March 2019

17 June 2019

18 November 2019

4 February 2021

19 July 2022

on focus list of Wikimedia project

0 references

Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223424

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The number of patients and events required to limit the risk of overestimation of intervention effects in meta-analysis--a simulation study

1 reference

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5 July 2018

Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223424

5 July 2018

Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223424

5 July 2018

Sequential methods for random-effects meta-analysis

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5 July 2018

Long-term effects of intensive glucose lowering on cardiovascular outcomes

1 reference

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Effects of moderate intensity glycemic control after cardiac surgery

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Intensive glycemic control and macrovascular events in type 2 diabetes mellitus: a meta-analysis of randomized controlled trials

1 reference

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5 July 2018

Glycated hemoglobin and the risk of kidney disease and retinopathy in adults with and without diabetes

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Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial

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5 July 2018

Effects of medical therapies on retinopathy progression in type 2 diabetes

1 reference

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5 July 2018

The effect of intensive glucose control on all-cause and cardiovascular mortality, myocardial infarction and stroke in persons with type 2 diabetes mellitus: a systematic review and meta-analysis

1 reference

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5 July 2018

Glycaemic control and restenosis after percutaneous coronary interventions in patients with diabetes mellitus: a report from the Insulin Diabetes Angioplasty study.

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Effects of combination lipid therapy in type 2 diabetes mellitus

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5 July 2018

Effects of intensive blood-pressure control in type 2 diabetes mellitus

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3-year follow-up of clinical and behavioral improvements following a multifaceted diabetes care intervention: results of a randomized controlled trial

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5 July 2018

The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study

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The Bypass Angioplasty Revascularization Investigation 2 Diabetes randomized trial of different treatment strategies in type 2 diabetes mellitus with stable ischemic heart disease: impact of treatment strategy on cardiac mortality and [...]

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Rosiglitazone decreases C-reactive protein to a greater extent relative to glyburide and metformin over 4 years despite greater weight gain: observations from a Diabetes Outcome Progression Trial (ADOPT)

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Intensive glucose control and macrovascular outcomes in type 2 diabetes.

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5 July 2018

Combined effects of routine blood pressure lowering and intensive glucose control on macrovascular and microvascular outcomes in patients with type 2 diabetes: New results from the ADVANCE trial

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Systematic review: glucose control and cardiovascular disease in type 2 diabetes

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5 July 2018

Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials

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5 July 2018

Effects of structured versus usual care on renal endpoint in type 2 diabetes: the SURE study: a randomized multicenter translational study

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Effects of prandial versus fasting glycemia on cardiovascular outcomes in type 2 diabetes: the HEART2D trial

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Comparison of three protocols for tight glycemic control in cardiac surgery patients

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5 July 2018

Glucose control and vascular complications in veterans with type 2 diabetes

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5 July 2018

Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes

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5 July 2018

10-year follow-up of intensive glucose control in type 2 diabetes

1 reference

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5 July 2018

Effects of intensive glucose lowering in type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223424

5 July 2018

Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes

1 reference

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5 July 2018

Cost-effectiveness of intensified versus conventional multifactorial intervention in type 2 diabetes: results and projections from the Steno-2 study

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5 July 2018

Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses

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Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis

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Severe hypoglycemia monitoring and risk management procedures in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial

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5 July 2018

Effects of structured hospital-based care compared with standard care for Type 2 diabetes-The Asker and Baerum Cardiovascular Diabetes Study, a randomized trial

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5 July 2018

Glycated hemoglobin as a marker of cardiovascular risk

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5 July 2018

Efficacy of intensive multitherapy for patients with type 2 diabetes mellitus: a randomized controlled trial

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5 July 2018

Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial

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5 July 2018

Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events.

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5 July 2018

Design of the cooperative study on glycemic control and complications in diabetes mellitus type 2: Veterans Affairs Diabetes Trial

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5 July 2018

Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study

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A randomized double-blind trial of acarbose in type 2 diabetes shows improved glycemic control over 3 years (U.K. Prospective Diabetes Study 44)

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Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group

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Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

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5 July 2018

Evaluation of a pharmaceutical care model on diabetes management

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5 July 2018

Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study

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5 July 2018

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5 July 2018

Effect of intravenous infusion of insulin in diabetics with acute myocardial infarction

1 reference

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5 July 2018

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5 July 2018

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5 July 2018

Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. VII. Mortality and selected nonfatal events with insulin treatment

1 reference

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5 July 2018

Severe hypoglycemia and risks of vascular events and death

1 reference

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28 October 2018

Intensified glucose lowering in type 2 diabetes: time for a reappraisal

1 reference

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28 October 2018

Effect of targeting normal fasting glucose levels with basal insulin glargine on glycaemic variability and risk of hypoglycaemia: a randomized, controlled study in patients with early Type 2 diabetes

1 reference

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28 October 2018

Improving glycaemic control self-efficacy and glycaemic control behaviour in Chinese patients with type 2 diabetes mellitus: randomised controlled trial

1 reference

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28 October 2018

Effects of intensive glucose control on incidence of cardiovascular events in patients with type 2 diabetes: a meta-analysis

1 reference

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28 October 2018

Effects of five-year intensive multifactorial intervention on the serum amyloid A and macroangiopathy in patients with short-duration type 2 diabetes mellitus.

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28 October 2018

The association between intensive glycemic control and vascular complications in type 2 diabetes mellitus: a meta-analysis

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28 October 2018

The response to short-term intensive insulin therapy in type 2 diabetes

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28 October 2018

Clinical inertia in general practice: widespread and related to the outcome of diabetes care

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28 October 2018

Effects of blood pressure lowering and intensive glucose control on the incidence and progression of retinopathy in patients with type 2 diabetes mellitus: a randomised controlled trial.

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28 October 2018

Prevention of cardiovascular disease through glycemic control in type 2 diabetes: a meta-analysis of randomized clinical trials.

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28 October 2018

[Effect of strict glycemic control on clinical state and course of the disease in patients with chronic heart failure and type II diabetes mellitus. Results of the REMBO "rational effective multicomponent therapy in the struggle against diabetes mel

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28 October 2018

Effect of short term intensive multitherapy on carotid intima-media thickness in patients with newly diagnosed type 2 diabetes mellitus.

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28 October 2018

Glycaemic separation and risk factor control in the Veterans Affairs Diabetes Trial: an interim report.

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28 October 2018

Treatment intensification in patients with type 2 diabetes

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28 October 2018

Effect of a multifactorial intervention on mortality in type 2 diabetes

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28 October 2018

The impact of glucose lowering treatment on long-term prognosis in patients with type 2 diabetes and myocardial infarction: a report from the DIGAMI 2 trial.

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28 October 2018

Long-term intensive glycemic and lipid control ameliorates the carotid intima medial thickness in type 2 diabetes mellitus

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28 October 2018

Effects of improved metabolic control on platelet reactivity in patients with type 2 diabetes mellitus following coronary angioplasty.

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28 October 2018

Global Guideline for Type 2 Diabetes: recommendations for standard, comprehensive, and minimal care.

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28 October 2018

Health-related quality of life in the VA Feasibility Study on glycemic control and complications in type 2 diabetes mellitus

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28 October 2018

Cost-utility analyses of intensive blood glucose and tight blood pressure control in type 2 diabetes (UKPDS 72).

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28 October 2018

Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity

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28 October 2018

Short-term intensive insulin therapy in newly diagnosed type 2 diabetes

1 reference

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28 October 2018

Improved metabolic control decreases platelet activation markers in patients with type-2 diabetes

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28 October 2018

Optimal glycemic control is associated with a lower rate of target vessel revascularization in treated type II diabetic patients undergoing elective percutaneous coronary intervention

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28 October 2018

Improvement of glycaemic control in type 2 diabetes: favourable changes in blood pressure, total cholesterol and triglycerides, but not in HDL cholesterol, fibrinogen, Von Willebrand factor and (pro)insulin.

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28 October 2018

Effect of intravenous insulin administration on left ventricular performance during non-ST-elevation acute coronary events in patients with diabetes mellitus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223424

28 October 2018

Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223424

28 October 2018

Intensive insulin treatment reduces transient ischaemic episodes during acute coronary events in diabetic patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223424

28 October 2018

The effects of intensive glycaemic control on body composition in patients with type 2 diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223424

28 October 2018

Evidence of a threshold value of glycated hemoglobin to improve the course of renal function in type 2 diabetes with typical diabetic glomerulopathy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223424

28 October 2018

The influences of obesity and glycemic control on endothelial activation in patients with type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223424

28 October 2018

Effects of improved glycaemic control on endothelial function in patients with type 2 diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223424

28 October 2018

Cost-effectiveness analysis of intensive blood-glucose control with metformin in overweight patients with type II diabetes (UKPDS No. 51).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223424

28 October 2018

Effect of intensive glycemic control on microalbuminuria in type 2 diabetes. Veterans Affairs Cooperative Study on Glycemic Control and Complications in Type 2 Diabetes Feasibility Trial Investigators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223424

28 October 2018

Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223424

28 October 2018

Cost-effectiveness of intensive insulin therapy for type 2 diabetes: a 10-year follow-up of the Kumamoto study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223424

28 October 2018

Randomized study of two different target levels of glycemic control within the acceptable range in type 2 diabetes. Effects on well-being at 1 year.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223424

28 October 2018

Response to intensive therapy steps and to glipizide dose in combination with insulin in type 2 diabetes. VA feasibility study on glycemic control and complications (VA CSDM).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223424

28 October 2018

Veterans Affairs Cooperative Study on glycemic control and complications in type II diabetes (VA CSDM). Results of the feasibility trial. Veterans Affairs Cooperative Study in Type II Diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223424

28 October 2018

Effect of blood glucose control on peripheral nerve function in diabetic patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223424

28 October 2018

Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial: Design and Methods

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223424

28 October 2018

Diabetes Care Protocol: effects on patient-important outcomes. A cluster randomized, non-inferiority trial in primary care

1 reference

https://pubmed.ncbi.nlm.nih.gov/22115901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intensified multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: the Steno type 2 randomised study

1 reference

https://pubmed.ncbi.nlm.nih.gov/22115901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quality of life in type 2 diabetic patients is affected by complications but not by intensive policies to improve blood glucose or blood pressure control (UKPDS 37). U.K. Prospective Diabetes Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/22115901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of insulin treatment on cause-specific one-year mortality and morbidity in diabetic patients with acute myocardial infarction. DIGAMI Study Group. Diabetes Insulin-Glucose in Acute Myocardial Infarction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22115901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Continuous intravenous insulin infusion reduces the incidence of deep sternal wound infection in diabetic patients after cardiac surgical procedures

1 reference

https://pubmed.ncbi.nlm.nih.gov/22115901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of strict metabolic control by insulin infusion on fibrinolytic profile during an acute coronary event in diabetic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/22115901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induced basal normoglycemia and altered platelet aggregation in non-insulin-dependent diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22115901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. II. Mortality results

1 reference

https://pubmed.ncbi.nlm.nih.gov/22115901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycemic control and complications in type II diabetes. Design of a feasibility trial. VA CS Group (CSDM)

1 reference

https://pubmed.ncbi.nlm.nih.gov/22115901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is intensive glycemic control worth the expense?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22115901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluations of retinopathy in the VA Cooperative Study on Glycemic Control and Complications in Type II Diabetes (VA CSDM). A feasibility study

1 reference

https://pubmed.ncbi.nlm.nih.gov/22115901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. VIII. Evaluation of insulin therapy: final report

1 reference

https://pubmed.ncbi.nlm.nih.gov/22115901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

UK Prospective Diabetes Study (UKPDS). VIII. Study design, progress and performance

1 reference

https://pubmed.ncbi.nlm.nih.gov/22115901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1136/BMJ.D6898

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

ResearchGate publication ID

0 references

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