Natural product libraries to accelerate the high-throughput discovery of therapeutic leads (Q34086801)

30 July 2017

title

Natural product libraries to accelerate the high-throughput discovery of therapeutic leads (English)

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30 July 2017

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15

James H McKerrow

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30 July 2017

16

Kyria Boundy-Mills

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30 July 2017

22

Phillip Crews

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30 July 2017

Tyler A Johnson

1

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30 July 2017

Johann Sohn

2

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30 July 2017

Wayne D Inman

3

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30 July 2017

Samarkand A Estee

4

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30 July 2017

Steven T Loveridge

5

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30 July 2017

Helene C Vervoort

6

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Karen Tenney

7

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30 July 2017

Junke Liu

8

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30 July 2017

Kenny Kean-Hooi Ang

9

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30 July 2017

Joseline Ratnam

10

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30 July 2017

Walter M Bray

11

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30 July 2017

Nadine C Gassner

12

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30 July 2017

Young Y Shen

13

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30 July 2017

R Scott Lokey

14

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30 July 2017

Arif Nukanto

17

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30 July 2017

Atit Kanti

18

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30 July 2017

Heddy Julistiono

19

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30 July 2017

Leonardus B S Kardono

20

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30 July 2017

Leonard F Bjeldanes

21

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30 July 2017

publication date

30 November 2011

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Journal of Natural Products

30 July 2017

published in

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30 July 2017

volume

74

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30 July 2017

issue

12

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30 July 2017

page(s)

2545-2555

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Biostructural features of additional jasplakinolide (jaspamide) analogues

30 July 2017

cites work

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Modern natural products drug discovery and its relevance to biodiversity conservation

5 July 2018

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The structural diversity and promise of antiparasitic marine invertebrate-derived small molecules

5 July 2018

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Azonazine, a Novel Dipeptide from a Hawaiian Marine Sediment-Derived Fungus, Aspergillus insulicola

5 July 2018

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The marine sponge metabolite mycothiazole: a novel prototype mitochondrial complex I inhibitor

5 July 2018

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High-throughput screening of natural products for cancer therapy

5 July 2018

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On the potential of natural products in the discovery of pharma leads: a case for reassessment

5 July 2018

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Automated high-throughput system to fractionate plant natural products for drug discovery

5 July 2018

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Development and validation of a rapid method for the detection of latrunculol A in plasma

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

Assessing pressurized liquid extraction for the high-throughput extraction of marine-sponge-derived natural products

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

A beta-carboline alkaloid from the Papua New Guinea marine sponge hyrtios reticulatus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

Semisynthetic latrunculin B analogs: studies of actin docking support a proposed mechanism for latrunculin bioactivity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

Drug discovery and natural products: end of an era or an endless frontier?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

Impact of natural products on developing new anti-cancer agents

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

The aignopsanes, a new class of sesquiterpenes from selected chemotypes of the sponge Cacospongia mycofijiensis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

Interrogating the bioactive pharmacophore of the latrunculin chemotype by investigating the metabolites of two taxonomically unrelated sponges.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

A novel delta opioid receptor antagonist, SoRI-9409, produces a selective and long-lasting decrease in ethanol consumption in heavy-drinking rats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

Evolving trends in the dereplication of natural product extracts. 2. The isolation of chrysaibol, an antibiotic peptaibol from a New Zealand sample of the mycoparasitic fungus Sepedonium chrysospermum.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

Pre-fractionated microbial samples--the second generation natural products library at Wyeth

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

Marine natural product libraries for high-throughput screening and rapid drug discovery

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

Natural products as a robust source of new drugs and drug leads: past successes and present day issues

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

Latrunculin A and its C-17-O-carbamates inhibit prostate tumor cell invasion and HIF-1 activation in breast tumor cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

Latrunculin with a highly oxidized thiazolidinone ring: structure assignment and actin docking.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

Sponge-derived fijianolide polyketide class: further evaluation of their structural and cytotoxicity properties

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

Natural products as sources of new drugs over the last 25 years

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

Accelerating the discovery of biologically active small molecules using a high-throughput yeast halo assay

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

A reassignment of (-)-mycothiazole and the isolation of a related diol

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

Synthesis and biological evaluation of simplified mycothiazole analogues

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

Lipopolysaccharide prevents doxorubicin-induced apoptosis in RAW 264.7 macrophage cells by inhibiting p53 activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

The evolving role of natural products in drug discovery

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

Cytotoxic and other metabolites of Aspergillus inhabiting the rhizosphere of Sonoran desert plants

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

High-throughput method for the production and analysis of large natural product libraries for drug discovery

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

Evaluation of marine sponge metabolites for cytotoxicity and signal transduction activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

The unexpected isolation of CTP-431, a novel thiopyrone from the sponge Cacospongia mycofijiensis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

Molecular diversity and intragenomic variability in the yeast genus Xanthophyllomyces: the origin of Phaffia rhodozyma?

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

Bioactivity profiling using HPLC/microtiter-plate analysis: application to a New Zealand marine alga-derived fungus, Gliocladium sp.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

Bioactive natural and semisynthetic latrunculins

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246535

A practical solid-phase synthesis of Glu7-phalloidin and entry into fluorescent F-actin-binding reagents

28 October 2018

1 reference

12 December 2020

A cyclitol derivative as a replication inhibitor from the marine sponge Petrosia sp

1 reference

12 December 2020

Glycolipids from Sponges. 11.1Isocrasserides, Novel Glycolipids with a Five-Membered Cyclitol Widely Distributed in Marine Sponges

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12 December 2020

Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis

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12 December 2020

Evolving trends in the dereplication of natural product extracts: new methodology for rapid, small-scale investigation of natural product extracts

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12 December 2020

New Cytotoxic Macrolides from the SpongeFasciospongia rimosa

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12 April 2024

https://opencitations.net/index/api/v1/citations/10.1246/CL.1996.255

Identifiers

DOI

10.1021/NP200673B

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30 July 2017

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30 July 2017

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