Immune effects and mechanisms of action of CpG motifs (Q34088619)

30 July 2017

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title

Immune effects and mechanisms of action of CpG motifs (English)

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30 July 2017

Krieg AM

1

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PubMed ID

11090712

30 July 2017

language of work or name

English

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publication date

1 November 2000

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30 July 2017

5

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inferred from page(s)

published in

Vaccine

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30 July 2017

19

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30 July 2017

6

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30 July 2017

618-622

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In vitro augmentation of natural killer cell activity and production of interferon-alpha/beta and -gamma with deoxyribonucleic acid fraction from Mycobacterium bovis BCG.

30 July 2017

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DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth

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CpG motifs in bacterial DNA trigger direct B-cell activation

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Heterogeneity of genomes: measures and values

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Selection against CpG dinucleotides in lentiviral genes: a possible role of methylation in regulation of viral expression

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Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs

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Patterns of intracellular compartmentalization, trafficking and acidification of 5'-fluorescein labeled phosphodiester and phosphorothioate oligodeoxynucleotides in HL60 cells

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DNA binding to human leukocytes. Evidence for a receptor-mediated association, internalization, and degradation of DNA

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Modification of antisense phosphodiester oligodeoxynucleotides by a 5' cholesteryl moiety increases cellular association and improves efficacy

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Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-alpha-mediated shock

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CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation

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Unmethylated CpG motifs protect murine B lymphocytes against Fas-mediated apoptosis

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Bacterial DNA-induced NK cell IFN-gamma production is dependent on macrophage secretion of IL-12

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Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells.

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CpG DNA and LPS induce distinct patterns of activation in human monocytes

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CpG DNA: a potent signal for growth, activation, and maturation of human dendritic cells

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CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity

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CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants

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DNA as an adjuvant: capacity of insect DNA and synthetic oligodeoxynucleotides to augment T cell responses to specific antigen

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Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants.

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CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans

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Synthetic oligodeoxynucleotides containing CpG motifs enhance immunogenicity of a peptide malaria vaccine in Aotus monkeys.

1 reference

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CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus

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CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice

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Dual function of Drosophila cells as APCs for naive CD8+ T cells: implications for tumor immunotherapy

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Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization

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CpG DNA: a pathogenic factor in systemic lupus erythematosus?

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Modulation of renal disease in autoimmune NZB/NZW mice by immunization with bacterial DNA.

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Do DNA vaccines induce autoimmune disease?

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Bacterial DNA causes septic shock

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10.1016/S0264-410X(00)00249-8

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

11090712