Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase (Q34088830)

30 July 2017

Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase (English)

1 reference

30 July 2017

Emma J Shanks

3

0 references

Paul G. Wyatt

Paul G Wyatt

6

0 references

Ian H. Gilbert

Ian H Gilbert

5

0 references

Alan Fairlamb

Alan H Fairlamb

7

0 references

Deuan C Jones

2

Deuan C Jones

1 reference

30 July 2017

4

Julie A Frearson

1 reference

30 July 2017

Stephen Patterson

1

1 reference

30 July 2017

1 August 2009

1 reference

30 July 2017

1 reference

30 July 2017

4

1 reference

30 July 2017

8

1 reference

30 July 2017

1341-1353

1 reference

Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis

30 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929374

Kinetoplastids: related protozoan pathogens, different diseases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929374

High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929374

Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929374

Innovative lead discovery strategies for tropical diseases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929374

Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfi

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929374

Time-dependent inhibitors of trypanothione reductase: analogues of the spermidine alkaloid lunarine and related natural products

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929374

Mechanism and structure-activity relationships of norspermidine-based peptidic inhibitors of trypanothione reductase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929374

Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929374

Potent and specific inhibitors of trypanothione reductase from Trypanosoma cruzi: bis(2-aminodiphenylsulfides) for fluorescent labeling studies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929374

Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929374

Synthesis and biological evaluation of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine homologues at dopamine-uptake and phencyclidine- and sigma-binding sites

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929374

Nitrogen analogues of phencyclidine: 1-alkyl-4-phenyl-4-(1-piperidinyl)piperidines.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929374

[3H]N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine ([3H]BTCP): a new phencyclidine analog selective for the dopamine uptake complex.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929374

Role of the aromatic group in the inhibition of phencyclidine binding and dopamine uptake by PCP analogs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929374

Synthesis, stereochemistry, and biological activity of the 1-(1-phenyl-2-methylcyclohexyl)piperidines and the 1-(1-phenyl-4-methylcyclohexyl)piperidines. Absolute configuration of the potent trans-(-)-1-(1-phenyl-2-methylcyclohexyl)piperidine

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929374

Metabolism and functions of trypanothione in the Kinetoplastida

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929374

Dithiol proteins as guardians of the intracellular redox milieu in parasites: old and new drug targets in trypanosomes and malaria-causing plasmodia

5 July 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900098

Diaryl sulfide-based inhibitors of trypanothione reductase: inhibition potency, revised binding mode and antiprotozoal activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900098

Further studies of the structure-activity relationships of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine. Synthesis and evaluation of 1-(2-benzo[b]thienyl)-N,N-dialkylcyclohexylamines at dopamine uptake and phencyclidine binding sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900098

Ellman's-reagent-mediated regeneration of trypanothione in situ: substrate-economical microplate and time-dependent inhibition assays for trypanothione reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900098

Preparation of tertiary alkyl carbinamines, propargylamines, and alpha-heteroarylamines by ketone-based aminoalkylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900098

The crystal structure of trypanothione reductase from the human pathogen Trypanosoma cruzi at 2.3 A resolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900098

A comparative study of methylglyoxal metabolism in trypanosomatids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900098

21 January 2018

Identifiers

DOI

10.1002/CMDC.200900098

1 reference

30 July 2017

1 reference

30 July 2017

1 reference

PubMed ID

19557802