A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity. (Q34099015)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12118120%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

title

A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity (English)

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10 November 2019

2

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10 November 2019

author name string

Richard Y T Kao

1

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10 November 2019

Karen A Olson

3

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10 November 2019

Marc E Key

4

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10 November 2019

James W Fett

5

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10 November 2019

Robert Shapiro

6

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10 November 2019

language of work or name

English

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publication date

12 July 2002

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10 November 2019

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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10 November 2019

volume

99

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10 November 2019

issue

15

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10 November 2019

page(s)

10066-10071

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The Ribonucleolytic Activity of Angiogenin†

10 November 2019

cites work

1 reference

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Antiplasmin activity of a peptide that binds to the receptor-binding site of angiogenin

5 July 2018

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Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening

5 July 2018

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Antisense therapeutics: lessons from early clinical trials

5 July 2018

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Is there a difference between leads and drugs? A historical perspective

5 July 2018

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Small molecule inhibitors of RNase A and related enzymes

5 July 2018

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Tumor angiogenesis as a therapeutic target

5 July 2018

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Cleavage of 3',5'-pyrophosphate-linked dinucleotides by ribonuclease A and angiogenin

5 July 2018

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Binding of phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X-ray crystallography

5 July 2018

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5 July 2018

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Hypersensitive substrate for ribonucleases

5 July 2018

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Hypoxia-induced up-regulation of angiogenin in human malignant melanoma

5 July 2018

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Refined crystal structures of native human angiogenin and two active site variants: implications for the unique functional properties of an enzyme involved in neovascularisation during tumour growth

5 July 2018

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Chimeric anti-angiogenin antibody cAb 26-2F inhibits the formation of human breast cancer xenografts in athymic mice

5 July 2018

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Non-small-cell lung carcinoma tumor growth without morphological evidence of neo-angiogenesis.

5 July 2018

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A combined kinetic and modeling study of the catalytic center subsites of human angiogenin

5 July 2018

1 reference

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Role of glutamine-117 in the ribonucleolytic activity of human angiogenin.

5 July 2018

1 reference

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Nuclear translocation of angiogenin in proliferating endothelial cells is essential to its angiogenic activity

5 July 2018

1 reference

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Alteration of the enzymatic specificity of human angiogenin by site-directed mutagenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126625

Angiogenin antagonists prevent tumor growth in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126625

Isolation and characterization of a human colon carcinoma-secreted enzyme with pancreatic ribonuclease-like activity

5 July 2018

1 reference

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Amino acid sequence of human tumor derived angiogenin

5 July 2018

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Characterization of ribonucleolytic activity of angiogenin towards tRNA

5 July 2018

1 reference

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Role of lysines in human angiogenin: chemical modification and site-directed mutagenesis

5 July 2018

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Site-directed mutagenesis of histidine-13 and histidine-114 of human angiogenin. Alanine derivatives inhibit angiogenin-induced angiogenesis

5 July 2018

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Mutagenesis of aspartic acid-116 enhances the ribonucleolytic activity and angiogenic potency of angiogenin

5 July 2018

1 reference

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Characteristic ribonucleolytic activity of human angiogenin

5 July 2018

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Identification of functional arginines in human angiogenin by site-directed mutagenesis

5 July 2018

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Inhibition of prostate carcinoma establishment and metastatic growth in mice by an antiangiogenin monoclonal antibody

5 July 2018

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The most common chemical replacements in drug-like compounds.

21 January 2018

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Prevention of human prostate tumor metastasis in athymic mice by antisense targeting of human angiogenin.

21 January 2018

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The expression of angiogenin in tissue samples of different brain tumours and cultured glioma cells.

28 October 2018

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Angiogenin expression in human colorectal cancer: the role of focal macrophage infiltration

28 October 2018

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12 December 2020

Increased serum concentration of angiogenic factors in malignant melanoma patients correlates with tumor progression and survival

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12 December 2020

Increased angiogenin expression in the tumor tissue and serum of urothelial carcinoma patients is related to disease progression and recurrence

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12 December 2020

Interaction of heparin with human angiogenin

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12 December 2020

The observation of angiogenin and basic fibroblast growth factor gene expression in human colonic adenocarcinomas, gastric adenocarcinomas, and hepatocellular carcinomas

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12 December 2020

Angiogenic protein expression in advanced epithelial ovarian cancer

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12 December 2020

Renal cell carcinoma: relevance of angiogenetic factors

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12 December 2020

Increased angiogenin expression in gastric cancer correlated with cancer progression

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12 December 2020

Increased serum angiogenin concentration in colorectal cancer is correlated with cancer progression

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12 December 2020

Markers of tumor angiogenesis and proteolysis independently define high- and low-risk subsets of node-negative breast cancer patients

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12 December 2020

Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells

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12 December 2020

Increased angiogenin expression in pancreatic cancer is related to cancer aggressiveness

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12 December 2020

Identifiers

DOI

10.1073/PNAS.152342999

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12118120%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12118120%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

PubMed publication ID

12118120

1 reference