Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig (Q34099028)

31 July 2017

Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig (English)

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31 July 2017

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1 reference

Charles H Halsted

1

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31 July 2017

Jesus A Villanueva

2

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31 July 2017

Angela M Devlin

3

1 reference

31 July 2017

Onni Niemelä

4

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31 July 2017

Seppo Parkkila

5

1 reference

31 July 2017

Timothy A Garrow

6

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31 July 2017

Lynn M Wallock

7

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31 July 2017

Mark K Shigenaga

8

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31 July 2017

Stepan Melnyk

9

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31 July 2017

S Jill James

10

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31 July 2017

language of work or name

English

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publication date

16 July 2002

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Proceedings of the National Academy of Sciences of the United States of America

31 July 2017

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31 July 2017

99

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31 July 2017

10072-10077

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31 July 2017

15

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The role of Kupffer cell oxidant production in early ethanol-induced liver disease.

31 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Current concepts in the pathogenesis of alcoholic liver injury

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Nitric oxide inhibits methionine synthase activity in vivo and disrupts carbon flow through the folate pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Cytokines in alcoholic and nonalcoholic steatohepatitis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Differential role of ethanol and acetaldehyde in the induction of oxidative stress in HEP G2 cells: effect on transcription factors AP-1 and NF-kappaB

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

S-adenosylmethionine deficiency and TNF-alpha in lipopolysaccharide-induced hepatic injury.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

DNA oxidation matters: the HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Apoptosis and proliferation under conditions of deoxynucleotide pool imbalance in liver of folate/methyl deficient rats.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Functions of ceramide in coordinating cellular responses to stress

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Purification, kinetic properties, and cDNA cloning of mammalian betaine-homocysteine methyltransferase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Cytotoxic impact of DNA single vs double strand breaks in oxidatively injured cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Quantification of 3'OH DNA breaks by random oligonucleotide-primed synthesis (ROPS) assay

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B-12, and vitamin B-6 status

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Alcohol and the liver: 1994 update.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Folate-deficiency-induced homocysteinaemia in rats: disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Feeding S-adenosyl-L-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

DNA strand breaks produced by oxidative stress in mammalian cells exhibit 3'-phosphoglycolate termini.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Nitrous oxide has multiple deleterious effects on cobalamin metabolism and causes decreases in activities of both mammalian cobalamin-dependent enzymes in rats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Ethanol-induced changes in methionine metabolism in rat liver

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Cleavage of folates during ethanol metabolism. Role of acetaldehyde/xanthine oxidase-generated superoxide

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Hepatic content of S-adenosylmethionine, S-adenosylhomocysteine and glutathione in rats receiving treatments modulating methyl donor availability

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: status report

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Inhibition of glutathione synthesis in the liver leads to S-adenosyl-L-methionine synthetase reduction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

DNA damage by oxygen-derived species Its mechanism and measurement in mammalian systems

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Modulation of rat liver S-adenosylmethionine synthetase activity by glutathione

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

Assay of malondialdehyde and other alkanals in biological fluids by gas chromatography-mass spectrometry.

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.112336399

Centrilobular distribution of acetaldehyde and collagen in the ethanol-fed micropig.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.112336399

The body composition and lipid metabolic effects of long-term ethanol feeding during a high omega 6 polyunsaturated fatty acid diet in micropigs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.112336399

Isotope dilution high-performance liquid chromatography-electrospray tandem mass spectrometry assay for the measurement of 8-oxo-7,8-dihydro-2'-deoxyguanosine in biological samples

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

The effect of ethanol on one-carbon metabolism: Increased methionine catabolism and lipotrope methyl-group wastage

28 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.112336399

Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: Effect of membrane physical properties andS-adenosyl-L-methionine

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126626

In vitro inactivation of mammalian methionine synthase by nitric oxide

28 October 2018

1 reference

12 December 2020

Regulation of rat liver S-adenosylmethionine synthetase during septic shock: role of nitric oxide

1 reference

12 December 2020

Incidence and Significance of Hypovitaminemia in a Randomly Selected Municipal Hospital Population

1 reference

12 December 2020

The evolution of anemia in alcoholic patients

1 reference

12 December 2020

Decreased jejunal uptake of labeled folic acid ( 3 H-PGA) in alcoholic patients: roles of alcohol and nutrition

1 reference

12 December 2020

Labile methyl balances for normal humans on various dietary regimens

1 reference

12 December 2020

Activation of cystathionine synthase by adenosylmethionine and adenosylethionine

1 reference

12 December 2020

Folate Deficiency in the Alcoholic—its Relationship to Clinical and Haematological Abnormalities, Liver Disease and Folate Stores

1 reference

12 December 2020

Intestinal absorption of [3H]folic acid in the chronic alcoholic monkey

1 reference

12 December 2020

Hepatic folate metabolism in the chronic alcoholic monkey

1 reference

12 December 2020

Folate turnover in chronically alcoholic monkeys

1 reference

12 December 2020

Increased urinary excretion and prolonged turnover time of folic acid during ethanol ingestion

1 reference

12 December 2020

Effects of prolonged ethanol feeding on methionine metabolism in rat liver

1 reference

12 December 2020

Effects of chronic ethanol and diet treatment on urinary folate excretion and development of folate deficiency in the rat

1 reference

12 December 2020

S-adenosyl-L-methionine attenuates alcohol-induced liver injury in the baboon

1 reference

12 December 2020

Expression of testosterone-dependent enzyme, carbonic anhydrase III, and oxidative stress in experimental alcoholic liver disease

1 reference

12 December 2020

Measurement of plasma and intracellular S-adenosylmethionine and S-adenosylhomocysteine utilizing coulometric electrochemical detection: alterations with plasma homocysteine and pyridoxal 5'-phosphate concentrations

1 reference

12 December 2020

Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation

1 reference

12 December 2020

Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats

1 reference

12 December 2020

Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease

1 reference

12 December 2020

Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol

1 reference

12 December 2020

A sensitive new method for rapid detection of abnormal methylation patterns in global DNA and within CpG islands

1 reference

12 December 2020

Induction of cytochrome P450 enzymes and generation of protein-aldehyde adducts are associated with sex-dependent sensitivity to alcohol-induced liver disease in micropigs

1 reference

12 December 2020

Correlation of folate deficiency with alcoholism and associated macrocytosis, anemia, and liver disease

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.112336399

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31 July 2017

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31 July 2017

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