Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering (Q34100591)

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10 February 2020

title

Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering (English)

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10 February 2020

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6

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10 February 2020

Henrik Biverstal

7

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10 February 2020

Christofer Lendel

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10 February 2020

Anatoly Dubnovitsky

10

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10 February 2020

Torleif Härd

13

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10 February 2020

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Lars Lannfelt

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10 February 2020

author name string

Anders Sandberg

1

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10 February 2020

Leila M Luheshi

2

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10 February 2020

Sofia Söllvander

3

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10 February 2020

Teresa Pereira de Barros

4

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10 February 2020

Bertil Macao

5

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10 February 2020

Frida Ekholm-Petterson

9

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10 February 2020

Christopher M Dobson

12

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10 February 2020

language of work or name

English

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publication date

16 August 2010

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Proceedings of the National Academy of Sciences of the United States of America

10 February 2020

published in

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10 February 2020

volume

107

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10 February 2020

page(s)

15595-15600

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10 February 2020

issue

35

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Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

10 February 2020

cites work

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Structural characterization of a soluble amyloid beta-peptide oligomer.

28 July 2018

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Recombinant amyloid beta-peptide production by coexpression with an affibody ligand

28 July 2018

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

28 July 2018

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Stabilization of a -hairpin in monomeric Alzheimer's amyloid- peptide inhibits amyloid formation

28 July 2018

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Why Alzheimer's is a disease of memory: the attack on synapses by A beta oligomers (ADDLs).

28 July 2018

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Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils

28 July 2018

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Sensitive ELISA detection of amyloid-beta protofibrils in biological samples

28 July 2018

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The Alzheimer's peptides Abeta40 and 42 adopt distinct conformations in water: a combined MD / NMR study

28 July 2018

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Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

28 July 2018

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Selection and characterization of Affibody ligands binding to Alzheimer amyloid beta peptides

28 July 2018

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Protein misfolding, functional amyloid, and human disease

28 July 2018

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A specific amyloid-beta protein assembly in the brain impairs memory

28 July 2018

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Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease

28 July 2018

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Structure of the cross-beta spine of amyloid-like fibrils

28 July 2018

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On the nucleation of amyloid beta-protein monomer folding

28 July 2018

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Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

28 July 2018

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

28 July 2018

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The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

28 July 2018

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

28 July 2018

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Amyloid beta-protein assembly and Alzheimer disease

28 July 2018

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Abeta-globulomers are formed independently of the fibril pathway

21 January 2018

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Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.

21 January 2018

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Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation

21 January 2018

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Antiparallel beta-sheet: a signature structure of the oligomeric amyloid beta-peptide

21 January 2018

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Cold-active beta-galactosidase from Arthrobacter sp. C2-2 forms compact 660 kDa hexamers: crystal structure at 1.9A resolution

21 January 2018

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Effects of the Arctic (E22-->G) mutation on amyloid beta-protein folding: discrete molecular dynamics study

21 January 2018

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Distinct early folding and aggregation properties of Alzheimer amyloid-beta peptides Abeta40 and Abeta42: stable trimer or tetramer formation by Abeta42.

21 January 2018

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Comparing the folding free-energy landscapes of Abeta42 variants with different aggregation properties

21 January 2018

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Structural studies of soluble oligomers of the Alzheimer beta-amyloid peptide

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20713699

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Multiple assembly pathways underlie amyloid-beta fibril polymorphisms

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20713699

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1001740107

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10 February 2020

0 references

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10 February 2020

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